INT90771

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Context Info
Confidence 0.48
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 8.43
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptprc)
Anatomy Link Frequency
leukocyte 2
blood 1
reticular thalamic nucleus 1
Ptprc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
medulla 6 99.20 Very High Very High Very High
ischemia 18 97.60 Very High Very High Very High
Pain 5 88.16 High High
Chronic pancreatitis 3 85.04 High High
Inflammation 37 81.60 Quite High
Arthritis 2 75.92 Quite High
Glutamate receptor 5 75.00 Quite High
Thalamus 3 75.00 Quite High
Inflammatory response 4 65.60 Quite High
cytokine 31 56.40 Quite High
Disease Link Frequency Relevance Heat
Myocardial Infarction 6 98.40 Very High Very High Very High
Postoperative Complications 9 98.32 Very High Very High Very High
Cv Unclassified Under Development 19 97.60 Very High Very High Very High
Metastasis 117 97.24 Very High Very High Very High
Rectal Cancer 324 92.32 High High
Recurrence 288 92.04 High High
Cancer 291 91.68 High High
Disease 185 91.60 High High
Diabetes Mellitus 77 90.16 High High
Disorders Of Creatine Metabolism 5 89.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the isoforms of CD45 which are generated by alternative mRNA splicing were analysed using reverse transcription followed by the polymerase chain reaction-technique (RT-PCR).
Positive_regulation (generated) of CD45
1) Confidence 0.48 Published 2002 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 12030436 Disease Relevance 0.33 Pain Relevance 0.28
Preoperative RT versus postoperative adjuvant RT in high-risk cases
Positive_regulation (Preoperative) of RT
2) Confidence 0.35 Published 2003 Journal BMC Med Section Body Doc Link PMC281590 Disease Relevance 0.80 Pain Relevance 0
Postoperative complications, both early [30] and late [37], were significantly more frequent after higher-dose postoperative RT.
Positive_regulation (postoperative) of RT associated with postoperative complications
3) Confidence 0.35 Published 2003 Journal BMC Med Section Body Doc Link PMC281590 Disease Relevance 0.49 Pain Relevance 0
Preoperative RT alone versus preoperative RT plus chemotherapy
Positive_regulation (Preoperative) of RT
4) Confidence 0.35 Published 2003 Journal BMC Med Section Body Doc Link PMC281590 Disease Relevance 0.54 Pain Relevance 0
The increased morbidity of the postoperative RT must be related in part to the higher radiation dose given.
Positive_regulation (increased) of RT
5) Confidence 0.35 Published 2003 Journal BMC Med Section Body Doc Link PMC281590 Disease Relevance 0.39 Pain Relevance 0.03
Preoperative RT alone versus preoperative RT plus chemotherapy
Positive_regulation (Preoperative) of RT
6) Confidence 0.35 Published 2003 Journal BMC Med Section Body Doc Link PMC281590 Disease Relevance 0.55 Pain Relevance 0
Preoperative RT alone versus preoperative RT plus chemotherapy
Positive_regulation (preoperative) of RT
7) Confidence 0.35 Published 2003 Journal BMC Med Section Body Doc Link PMC281590 Disease Relevance 0.54 Pain Relevance 0
Preoperative RT versus postoperative adjuvant RT in high-risk cases
Positive_regulation (postoperative) of RT
8) Confidence 0.35 Published 2003 Journal BMC Med Section Body Doc Link PMC281590 Disease Relevance 0.80 Pain Relevance 0
Preoperative RT with surgery at different intervals
Positive_regulation (Preoperative) of RT
9) Confidence 0.35 Published 2003 Journal BMC Med Section Body Doc Link PMC281590 Disease Relevance 0.49 Pain Relevance 0
Preoperative RT versus postoperative adjuvant RT in high-risk cases
Positive_regulation (Preoperative) of RT
10) Confidence 0.35 Published 2003 Journal BMC Med Section Body Doc Link PMC281590 Disease Relevance 0.80 Pain Relevance 0
Although they expressed CD29 and CD90, a majority of adherent cells were negative for CD34 and CD45, which is consistent with MSCs previously reported (8,21).


Positive_regulation (negative) of CD45
11) Confidence 0.22 Published 2008 Journal Diabetes Section Body Doc Link PMC2570407 Disease Relevance 0.48 Pain Relevance 0
The quantitative analysis of fluorescence intensity of CD45, a leukocyte marker, shows that the total amount of CD45-positive cells, mainly localized in corticomedullary area, was increased in the high Vt+Vehicle as compared with the low Vt+Vehicle group.
Positive_regulation (increased) of CD45 in leukocyte
12) Confidence 0.15 Published 2010 Journal Crit Care Section Body Doc Link PMC2887157 Disease Relevance 0.43 Pain Relevance 0
It has been demonstrated that hydrogen peroxide inhibits CD45 (a transmembrane tyrosine phosphatase expressed in cells of monocytic lineage) [30], and it has recently been shown that the activation of CD45 blocks GM-CSF-induced microglial proliferation [31].
Positive_regulation (activation) of CD45
13) Confidence 0.12 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1574293 Disease Relevance 0.32 Pain Relevance 0.13
After adjusting for age and sex, unit increases in both tissue plasminogen activator antigen and leucocyte elastase levels were significantly associated with an increased risk of a cardiovascular event.
Positive_regulation (increases) of leucocyte elastase in leucocyte
14) Confidence 0.06 Published 2000 Journal Eur. Heart J. Section Body Doc Link 10988013 Disease Relevance 0.07 Pain Relevance 0
The reduced expression of mGluR1, 4 and 7 transcripts in VB and Po, and the increases of mGluR3 mRNA in the Rt may contribute to counteract the increased noxious input arising from the periphery.
Positive_regulation (increases) of Rt
15) Confidence 0.06 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11000486 Disease Relevance 0.13 Pain Relevance 0.29
Similar decreases of mGluR7 mRNA expression in the VB and Po were found at all time points, while mGluR3 mRNA expression was bilaterally increased in the reticular thalamic nucleus (Rt).
Positive_regulation (increased) of Rt in reticular thalamic nucleus
16) Confidence 0.05 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11000486 Disease Relevance 0.15 Pain Relevance 0.34
Immunohistochemical staining was positive for CD45 (LCA), CD56 (N-CAM), CD43 (MT1), and cytokeratin CAM5.2.
Positive_regulation (positive) of CD45
17) Confidence 0.04 Published 2001 Journal J. Histochem. Cytochem. Section Abstract Doc Link 11373326 Disease Relevance 0.47 Pain Relevance 0.09
The expression(2)is accurate to 1% for RT/RB<0.25.


Positive_regulation (accurate) of RT
18) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808387 Disease Relevance 0 Pain Relevance 0
A single bolus of EPO has been shown to increase blood number of EPCs (CD34+/CD45?)
Positive_regulation (increase) of CD45 in blood
19) Confidence 0.04 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721378 Disease Relevance 0.67 Pain Relevance 0.12
containing 5% BSA and the blots incubated for 2 hours at RT or 4°C overnight
Positive_regulation (incubated) of RT
20) Confidence 0.03 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0 Pain Relevance 0

General Comments

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