INT90776

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Context Info
Confidence 0.69
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 0.92
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Kcnn3) cytoplasm (Kcnn3)
Anatomy Link Frequency
brain 2
microglia 2
respiratory 2
Kcnn3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
medulla 4 99.78 Very High Very High Very High
Thalamus 4 98.94 Very High Very High Very High
potassium channel 2 97.80 Very High Very High Very High
Hippocampus 8 96.40 Very High Very High Very High
Action potential 8 93.48 High High
Inflammation 27 83.12 Quite High
cva 33 79.20 Quite High
Dismenorea 2 77.04 Quite High
Neuronal excitability 4 62.12 Quite High
Pain 3 34.08 Quite Low
Disease Link Frequency Relevance Heat
Stroke 63 99.24 Very High Very High Very High
Hypoxia 2 98.28 Very High Very High Very High
Drug Induced Neurotoxicity 15 97.04 Very High Very High Very High
INFLAMMATION 30 83.12 Quite High
Cv General 4 Under Development 30 80.32 Quite High
Dislocations 3 36.00 Quite Low
Death 6 31.96 Quite Low
Apoptosis 18 6.40 Low Low
Schizophrenia 10 5.00 Very Low Very Low Very Low
Injury 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, SK3 overexpression induced abnormal respiratory responses to hypoxia and compromised parturition.
Positive_regulation (overexpression) of Gene_expression (overexpression) of SK3 in respiratory associated with hypoxia
1) Confidence 0.69 Published 2000 Journal Science Section Abstract Doc Link 10988076 Disease Relevance 0.10 Pain Relevance 0.16
Respiration and parturition affected by conditional overexpression of the Ca2+-activated K+ channel subunit, SK3.
Positive_regulation (overexpression) of Gene_expression (overexpression) of SK3
2) Confidence 0.69 Published 2000 Journal Science Section Title Doc Link 10988076 Disease Relevance 0.08 Pain Relevance 0.16
Having found that SK3 channels contribute to microglial activation in vitro, it was important to demonstrate SK3 expression in microglia in vivo, particularly in the damaged CNS.
Positive_regulation (activation) of Gene_expression (channels) of SK3 in microglia
3) Confidence 0.39 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0.42 Pain Relevance 0.12
When used to validate the SK3 immunostaining, non-transfected and stably transfected (with rSK3) CHO cells were grown in Iscove's Modified Dulbecco's Medium with 10% fetal bovine serum, HT supplement, antibiotic-antimycotic, and 0.4 ?
Positive_regulation (validate) of Gene_expression (immunostaining) of SK3
4) Confidence 0.34 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0.33 Pain Relevance 0.08
Blocking microglial SK3 channels reduces their neurotoxic capacity
Positive_regulation (microglial) of Gene_expression (channels) of SK3
5) Confidence 0.34 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0 Pain Relevance 0
Most of the higher brain regions such as the neocortex and hippocampus show expression of both genes encoding SK1 and SK2 channels, whereas phylogenetically older brain regions such as the thalamus, basal ganglia, cerebellum, and brainstem show high levels of SK3 gene expression.
Positive_regulation (levels) of Gene_expression (expression) of SK3 gene in brain associated with medulla, thalamus and hippocampus
6) Confidence 0.01 Published 2004 Journal Curr Drug Targets CNS Neurol Disord Section Abstract Doc Link 15180477 Disease Relevance 0 Pain Relevance 0.18

General Comments

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