INT90777

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Context Info
Confidence 0.77
First Reported 2000
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 39
Total Number 41
Disease Relevance 10.35
Pain Relevance 6.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Kcnn3) cytoplasm (Kcnn3)
Anatomy Link Frequency
microglia 10
brain 3
dorsal 2
caudate putamen 2
nervous system 2
Kcnn3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
medulla 33 99.58 Very High Very High Very High
Spinal cord 40 99.52 Very High Very High Very High
Migraine 32 99.50 Very High Very High Very High
monoamine 2 99.28 Very High Very High Very High
Action potential 69 99.12 Very High Very High Very High
cva 352 98.96 Very High Very High Very High
Thalamus 33 98.74 Very High Very High Very High
Eae 2 98.72 Very High Very High Very High
potassium channel 9 97.80 Very High Very High Very High
Serotonin 2 97.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stroke 672 99.96 Very High Very High Very High
Cancer 39 99.96 Very High Very High Very High
Apoptosis 192 99.88 Very High Very High Very High
Apnoea 35 99.76 Very High Very High Very High
Headache 32 99.50 Very High Very High Very High
Schizophrenia 97 99.24 Very High Very High Very High
Sudden Infant Death Syndrome 35 99.20 Very High Very High Very High
Hemorrhage 32 98.96 Very High Very High Very High
Injury 98 98.72 Very High Very High Very High
Hypoxia 3 98.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, SK3 overexpression induced abnormal respiratory responses to hypoxia and compromised parturition.
Gene_expression (overexpression) of SK3 in respiratory associated with hypoxia
1) Confidence 0.77 Published 2000 Journal Science Section Abstract Doc Link 10988076 Disease Relevance 0.10 Pain Relevance 0.16
Respiration and parturition affected by conditional overexpression of the Ca2+-activated K+ channel subunit, SK3.
Gene_expression (overexpression) of SK3
2) Confidence 0.77 Published 2000 Journal Science Section Title Doc Link 10988076 Disease Relevance 0.08 Pain Relevance 0.16
The SK3 gene was targeted by homologous recombination for the insertion of a gene switch that permitted experimental regulation of SK3 expression while retaining normal SK3 promoter function.
Gene_expression (expression) of SK3
3) Confidence 0.77 Published 2000 Journal Science Section Abstract Doc Link 10988076 Disease Relevance 0.09 Pain Relevance 0.16
In rats, the SK2 and SK3 channels are expressed in the ascending monoaminergic systems, in particular in the serotonin (5-HT) neurons of the raphe dorsalis nucleus (RDN).
Gene_expression (expressed) of SK3 in RDN associated with raphe, serotonin and monoamine
4) Confidence 0.75 Published 2009 Journal Brain Res. Section Abstract Doc Link 19446538 Disease Relevance 0 Pain Relevance 0.35
The family of calcium-activated slow-potassium (SK) channels comprises 3 members, the SK1, SK2 and SK3 channels, all expressed in neurons, known to mediate the slow-afterhyperpolarization occurring after action potentials.
Gene_expression (expressed) of SK3 in neurons associated with action potential
5) Confidence 0.65 Published 2009 Journal Brain Res. Section Abstract Doc Link 19446538 Disease Relevance 0 Pain Relevance 0.32
Having found that SK3 channels contribute to microglial activation in vitro, it was important to demonstrate SK3 expression in microglia in vivo, particularly in the damaged CNS.
Gene_expression (expression) of SK3 in microglia
6) Confidence 0.60 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0.43 Pain Relevance 0.13
Changes in SK3 expression have not been examined in the damaged CNS.
Gene_expression (expression) of SK3
7) Confidence 0.60 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0.29 Pain Relevance 0.03
Neuron cell bodies and axons are still present at this time after the stroke [37]; hence, this provides novel evidence that neuronal SK3 expression changes after acute CNS damage.
Gene_expression (expression) of SK3 in neuronal associated with stroke
8) Confidence 0.60 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0.39 Pain Relevance 0
(i) Transcripts for all three cloned SK channels (KCNN1, KCNN2, KCNN3) are expressed in microglia, but KCNN3 predominates and is the only channel up-regulated in LPS-activated microglia.
Gene_expression (expressed) of KCNN3 in microglia
9) Confidence 0.60 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0.25 Pain Relevance 0.12
Reports of SK3 expression in non-neuronal cells are very limited; it is expressed in astrocytes in the supraoptic nucleus and in olfactory ensheathing glial cells [51,52], and it contributes to vasodilation in response to endothelium-derived hyperpolarizing factor (EDHF) [53].
Gene_expression (expression) of SK3 in astrocytes associated with increased venous pressure under development
10) Confidence 0.60 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0.16 Pain Relevance 0.14
First, we compared transcript expression of KCNN1, KCNN2 and KCNN3 in microglia isolated from rat brain.
Gene_expression (expression) of KCNN3 in brain
11) Confidence 0.60 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0.14 Pain Relevance 0.18
SK3 is preferentially expressed in phylogenetically older brain regions (thalamus, basal ganglia, cerebellum, brainstem) [47-50]; for instance, KCNN3 mRNA [47] is relatively high in the caudate putamen and in dopaminergic neurons of the substantia nigra, and SK3 immunoreactivity [49] is present in the caudate putamen.
Gene_expression (expressed) of SK3 in brain associated with medulla, substantia nigra and thalamus
12) Confidence 0.60 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0.14 Pain Relevance 0.14
The isolated microglia were from neonatal rats and the in vivo studies were from adults; thus, SK3 is apparently expressed in microglia throughout post-natal development.
Gene_expression (expressed) of SK3 in microglia
13) Confidence 0.60 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0.08 Pain Relevance 0.10
We show that SK1, SK2, SK3 and IK1 are all expressed in DRG and spinal cord.
Gene_expression (expressed) of SK3 in spinal cord associated with spinal cord
14) Confidence 0.56 Published 2005 Journal Neuroscience Section Abstract Doc Link 15680700 Disease Relevance 0.55 Pain Relevance 0.59
Having found that SK3 channels contribute to microglial activation in vitro, it was important to demonstrate SK3 expression in microglia in vivo, particularly in the damaged CNS.
Gene_expression (channels) of SK3 in microglia
15) Confidence 0.52 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0.41 Pain Relevance 0.12
(i) Transcripts for all three cloned SK channels (KCNN1, KCNN2, KCNN3) are expressed in microglia, but KCNN3 predominates and is the only channel up-regulated in LPS-activated microglia.
Gene_expression (predominates) of KCNN3 in microglia
16) Confidence 0.52 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0.26 Pain Relevance 0.10
The Ca2+ activated SK3 channel is expressed in microglia in the rat striatum and contributes to microglia-mediated neurotoxicity in vitro

Background

Gene_expression (expressed) of SK3 in microglia associated with drug induced neurotoxicity
17) Confidence 0.46 Published 2010 Journal J Neuroinflammation Section Title Doc Link PMC2819255 Disease Relevance 0.18 Pain Relevance 0
After strokes, SK3 was highly expressed in activated microglia/macrophages within the lesions, but reduced in other cells.


Gene_expression (expressed) of SK3 in macrophages associated with stroke
18) Confidence 0.46 Published 2010 Journal J Neuroinflammation Section Abstract Doc Link PMC2819255 Disease Relevance 0.42 Pain Relevance 0.04
There are three mammalian SK channels (KCNN1/SK1, KCNN2/SK2, KCNN3/SK3), which are predominantly expressed in the nervous system.
Gene_expression (expressed) of KCNN3 in nervous system
19) Confidence 0.46 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0.18 Pain Relevance 0.27
The purpose of this study was to examine expression of KCNN3/SK3 in CNS microglia in vivo and in vitro, and to use an established in vitro model to determine if this channel contributes to the neurotoxic capacity of activated microglia.


Spec (examine) Gene_expression (expression) of SK3 in microglia
20) Confidence 0.46 Published 2010 Journal J Neuroinflammation Section Abstract Doc Link PMC2819255 Disease Relevance 0.17 Pain Relevance 0

General Comments

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