INT90778

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Context Info
Confidence 0.61
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.56
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Kcnn3) cytoplasm (Kcnn3)
Kcnn3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Migraine 3 99.72 Very High Very High Very High
Action potential 7 92.72 High High
potassium channel 1 88.48 High High
midbrain 3 84.40 Quite High
Hippocampus 6 81.36 Quite High
Dismenorea 1 65.92 Quite High
Substantia nigra 3 54.16 Quite High
medulla 3 48.80 Quite Low
Thalamus 3 47.28 Quite Low
Spinal cord 3 42.48 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 18 99.88 Very High Very High Very High
Apnoea 4 99.76 Very High Very High Very High
Headache 3 99.72 Very High Very High Very High
Schizophrenia 9 99.46 Very High Very High Very High
Sudden Infant Death Syndrome 4 99.20 Very High Very High Very High
Affective Disorder 3 98.00 Very High Very High Very High
Epilepsy 3 97.36 Very High Very High Very High
Stroke 63 87.12 High High
Hypoxia 1 85.44 High High
Ganglion Cysts 3 84.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The SK3 gene was targeted by homologous recombination for the insertion of a gene switch that permitted experimental regulation of SK3 expression while retaining normal SK3 promoter function.
Regulation (regulation) of Gene_expression (expression) of SK3
1) Confidence 0.61 Published 2000 Journal Science Section Abstract Doc Link 10988076 Disease Relevance 0.09 Pain Relevance 0.16
Changes in SK3 expression have not been examined in the damaged CNS.
Spec (examined) Regulation (Changes) of Gene_expression (expression) of SK3
2) Confidence 0.47 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0.29 Pain Relevance 0.03
SK3 channels contribute to a subset of microglial functions
Regulation (contribute) of Gene_expression (channels) of SK3
3) Confidence 0.30 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0.26 Pain Relevance 0
Although controversial, several studies have correlated trinucleotide polymorphisms in SK3 with schizophrenia and migraine [80,81], and changes in SK3 expression with sleep apnoea, sudden infant death syndrome, mood disorders, epilepsy and schizophrenia [24,26,46,82].
Regulation (changes) of Gene_expression (expression) of SK3 associated with epilepsy, apnoea, affective disorder, migraine, sudden infant death syndrome and schizophrenia
4) Confidence 0.18 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0.92 Pain Relevance 0.18

General Comments

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