INT90781

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Context Info
Confidence 0.69
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 1.00
Pain Relevance 6.11

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molecular_function (EM1) cellular_component (EM1)
Anatomy Mention Frequency
central nervous system 2
joint 1
periventricular nucleus 1
EM-2 1
Lever 1
EM1 (Arabidopsis thaliana)
Pain Term Frequency Confidence Heat
orphanin 12 99.96 Very High Very High Very High
Ventral tegmentum 20 99.92 Very High Very High Very High
Central nervous system 2 99.36 Very High Very High Very High
Opioid 12 98.72 Very High Very High Very High
Morphine 5 98.64 Very High Very High Very High
Nucleus accumbens 8 98.52 Very High Very High Very High
narcan 9 96.44 Very High Very High Very High
antagonist 7 96.08 Very High Very High Very High
opioid receptor 13 95.64 Very High Very High Very High
Enkephalin 4 95.40 Very High Very High Very High
Disease Term Frequency Confidence Heat
Pressure And Volume Under Development 3 97.08 Very High Very High Very High
Depression 1 95.12 Very High Very High Very High
Respiratory Failure 2 92.08 High High
Stress 2 87.60 High High
Inflammatory Pain 3 75.00 Quite High
INFLAMMATION 1 64.24 Quite High
Pressure Volume 2 Under Development 1 52.96 Quite High
Heart Rate Under Development 1 51.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Endomorphin-1 (EM1) is present throughout the central nervous system in rats, mice, and guinea pigs; however, the distribution of EM1 in hamsters has not been described.
Gene_expression (present) of EM1 in central nervous system associated with central nervous system
1) Confidence 0.69 Published 2001 Journal Brain Res. Bull. Section Abstract Doc Link 11786242 Disease Relevance 0 Pain Relevance 0.25
Minute ventilation (V(E)) in 2, 4, and 6% CO(2) was measured before and after systemic administration of EM1, endomorphin-2 (EM2), DAMGO, and morphine in the conscious rat.
Gene_expression (administration) of EM1 associated with morphine
2) Confidence 0.65 Published 2005 Journal Brain Res. Section Abstract Doc Link 16223471 Disease Relevance 0.18 Pain Relevance 1.14
Endomorphin-1 (EM1) is present throughout the central nervous system in rats, mice, and guinea pigs; however, the distribution of EM1 in hamsters has not been described.
Gene_expression (distribution) of EM1 in central nervous system associated with central nervous system
3) Confidence 0.52 Published 2001 Journal Brain Res. Bull. Section Abstract Doc Link 11786242 Disease Relevance 0 Pain Relevance 0.26
Lever-pressing for EM-1 in the VTA was extinguished when vehicle was substituted for the peptide and was reinstated when EM-1 reinforcement was re-established.
Gene_expression (Lever-pressing) of EM-1 in Lever associated with ventral tegmentum
4) Confidence 0.49 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12177217 Disease Relevance 0 Pain Relevance 0.86
EM1 (30, 100, and 200 microg), KYNA (30, 100, 200, and 400 microg), and their combinations in a fixed-dose ratio (1:1) were injected into the inflamed joint, and the pain threshold was determined repeatedly for 75 min after the drug administrations.
Gene_expression (injected) of EM1 in joint
5) Confidence 0.40 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19762760 Disease Relevance 0 Pain Relevance 0
However, compared with responses elicited by EM2 or DAMGO, EM1 decreased V E only at higher doses, and produced greater V E stimulation.
Gene_expression (produced) of EM1
6) Confidence 0.15 Published 2000 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 10988119 Disease Relevance 0.10 Pain Relevance 0.71
Both EM1-LI and EM2-LI cells were present in the periventricular nucleus, between the dorsomedial and ventromedial hypothalamus and between the ventromedial and arcuate nuclei.
Gene_expression (present) of EM1 in periventricular nucleus
7) Confidence 0.12 Published 2002 Journal J. Comp. Neurol. Section Abstract Doc Link 12442322 Disease Relevance 0 Pain Relevance 0.63
Like nociceptin, microinjection of endomorphin-1 (EM-1), an endogenous ligand for the opioid mu receptor, into the rostral NTS increased blood pressure and heart rate in a dose-dependent manner (0.04, 0.2, and 1 nmol).
Gene_expression (microinjection) of EM-1 in heart associated with pressure and volume under development, orphanin and opioid
8) Confidence 0.04 Published 2005 Journal Neuroscience Section Abstract Doc Link 15857705 Disease Relevance 0.38 Pain Relevance 0.99
Numerous beta-endorphin-containing and fewer EM-1- and EM-2-containing leukocytes were detected in subcutaneous tissue of inflamed paws.
Gene_expression (detected) of EM-1 in EM-2
9) Confidence 0.03 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16624955 Disease Relevance 0.35 Pain Relevance 1.28

General Comments

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