INT9079

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Context Info
Confidence 0.75
First Reported 1983
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 52
Total Number 55
Disease Relevance 31.20
Pain Relevance 21.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PPBP) extracellular region (PPBP)
Anatomy Link Frequency
plasma 16
platelet 16
blood 3
mononuclear cells 2
coronary sinus 1
PPBP (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 121 100.00 Very High Very High Very High
opioid receptor 59 100.00 Very High Very High Very High
narcan 14 100.00 Very High Very High Very High
carbamazepine 13 100.00 Very High Very High Very High
antagonist 39 99.98 Very High Very High Very High
mu opioid receptor 6 99.92 Very High Very High Very High
aspirin 26 99.68 Very High Very High Very High
ischemia 15 99.68 Very High Very High Very High
Morphine 212 99.56 Very High Very High Very High
depression 19 99.54 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 121 99.86 Very High Very High Very High
Increased Venous Pressure Under Development 47 99.80 Very High Very High Very High
Cv Unclassified Under Development 8 99.68 Very High Very High Very High
Cardiovascular Disease 46 99.56 Very High Very High Very High
Hemorrhage 11 99.56 Very High Very High Very High
Depression 19 99.54 Very High Very High Very High
Cv General 3 Under Development 95 99.34 Very High Very High Very High
Acute Coronary Syndrome 176 99.24 Very High Very High Very High
Stable Angina Pectoris 2 99.16 Very High Very High Very High
Coagulation Disorder 5 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Circulating levels of beta-thromboglobulin (beta-TG), as well as thrombin (clotting)-stimulated platelet release of thromboxane, were also determined.
Spec (determined) Gene_expression (levels) of beta-TG in platelet associated with coagulation disorder
1) Confidence 0.75 Published 1992 Journal Am. J. Hematol. Section Abstract Doc Link 1533087 Disease Relevance 0.65 Pain Relevance 0.10
Beta-thromboglobulin plasma levels in the first week after myocardial infarction: influence of thrombolytic therapy.
Gene_expression (levels) of Beta-thromboglobulin in plasma associated with myocardial infarction
2) Confidence 0.66 Published 1994 Journal Am. Heart J. Section Title Doc Link 8074007 Disease Relevance 0.45 Pain Relevance 0.12
In this study, betathromboglobulin (BTG) and fibrinopeptide A (FPA) in peripheral venous blood were measured in 20 patients with stable angina pectoris before and immediately after exercise-induced myocardial ischaemia; in 5 of the 20 patients stable angina was associated with typical peripheral artery disease.
Gene_expression (measured) of betathromboglobulin in artery associated with stable angina pectoris, angina, coronary artery disease and peripheral arterial disease
3) Confidence 0.65 Published 1987 Journal Eur. Heart J. Section Abstract Doc Link 2958280 Disease Relevance 0.89 Pain Relevance 0.41
Plasma beta-thromboglobulin levels and claudication degrees in patients with peripheral vascular disease.
Gene_expression (levels) of beta-thromboglobulin in Plasma associated with increased venous pressure under development
4) Confidence 0.65 Published 1986 Journal Angiology Section Title Doc Link 2424348 Disease Relevance 0.29 Pain Relevance 0.08
The 5HT levels in platelets and in plasma, the beta-thromboglobulin (beta-TG) levels in plasma, and the urinary excretion of 5-hydroxyindoleacetic acid (5HIAA) were measured in 40 patients with chronic tension-type headache and in 40 healthy controls.
Gene_expression (levels) of beta-thromboglobulin in plasma associated with 5ht and headache
5) Confidence 0.59 Published 1997 Journal Cephalalgia Section Abstract Doc Link 9453272 Disease Relevance 0.44 Pain Relevance 0.90
On admission, levels of beta-thromboglobulin, as compared to those in healthy subjects (35 +/- 9 IU/ml), were similarly augmented in group 1 (105 +/- 27 IU/ml) and in group 2 (115 +/- 30 IU/ml); 3 hours later, values averaged 191 +/- 58 IU/ml in group 1 (p < 0.001 vs baseline) and 95 +/- 28 IU/ml in group 2 (not significant vs baseline; p < 0.001 between the two groups).
Gene_expression (levels) of beta-thromboglobulin
6) Confidence 0.59 Published 1994 Journal Am. Heart J. Section Abstract Doc Link 8074007 Disease Relevance 0.38 Pain Relevance 0.12
The 5HT levels in platelets and in plasma, the beta-thromboglobulin (beta-TG) levels in plasma, and the urinary excretion of 5-hydroxyindoleacetic acid (5HIAA) were measured in 40 patients with chronic tension-type headache and in 40 healthy controls.
Gene_expression (levels) of beta-TG in plasma associated with 5ht and headache
7) Confidence 0.58 Published 1997 Journal Cephalalgia Section Abstract Doc Link 9453272 Disease Relevance 0.44 Pain Relevance 0.90
Inhibition of platelet cyclooxygenase (COX 1) by aspirin is followed by relief of microvascular disturbances, correction of shortened platelet survival, and return of plasma levels of beta-tg, PF4, TM levels and TxB2 excretion to normal.
Gene_expression (levels) of beta-tg in plasma associated with aspirin and cox1
8) Confidence 0.58 Published 2006 Journal Platelets Section Abstract Doc Link 17127481 Disease Relevance 1.35 Pain Relevance 0.21
Simultaneously, the plasma levels of platelet factor 4 (PF4) and of beta-thromboglobulin (beta-TG) were measured.
Gene_expression (levels) of beta-TG in platelet
9) Confidence 0.58 Published 1984 Journal Thromb. Haemost. Section Abstract Doc Link 6241754 Disease Relevance 0.52 Pain Relevance 0.12
Aspirin treatment of erythromelalgia in thrombocythemia patients resulted in the disappearance of the erythromelalgic, thrombotic signs and symptoms, correction of the shortened platelet survival times, and a significant reduction of the increased levels of beta-TG, PF4, TM and urinary TxB2 excretion to normal.
Gene_expression (levels) of beta-TG in platelet associated with aspirin, thrombocytosis and erythermalgia
10) Confidence 0.58 Published 2003 Journal Pathol. Biol. Section Abstract Doc Link 12781799 Disease Relevance 1.41 Pain Relevance 0.30
In this patient, platelet function was estimated in vivo by the levels of antiheparin platelet factor 4 and beta-thromboglobulin.
Gene_expression (levels) of beta-thromboglobulin in platelet
11) Confidence 0.58 Published 1992 Journal JPEN J Parenter Enteral Nutr Section Abstract Doc Link 1556816 Disease Relevance 1.07 Pain Relevance 0.11
As observed above, ICAM-1, IL-6, IL-8, GM-CSF, RANTES, MCP-1, GROalpha, NAP-2, and ENA-78 expression was reduced by the IKK inhibitors.
Gene_expression (expression) of NAP-2
12) Confidence 0.47 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16687566 Disease Relevance 0.42 Pain Relevance 0.41
To examine whether acute myocardial ischemia activates the coagulation system and platelet activation in the coronary circulation, we measured plasma levels of fibrinopeptide A and beta-thromboglobulin in the coronary sinus and the aortic root simultaneously in 15 patients with coronary spastic angina before and after the left coronary spasm induced by intracoronary injection of acetylcholine and in 15 patients with stable exertional angina before and after acute myocardial ischemia induced by rapid atrial pacing.
Gene_expression (levels) of beta-thromboglobulin in coronary sinus associated with spasticity, coronary artery disease, ischemia and cva
13) Confidence 0.45 Published 1990 Journal Circulation Section Abstract Doc Link 2146992 Disease Relevance 0.89 Pain Relevance 0.40
Ticlopidine also inhibits the release reaction of platelets, prolongs bleeding time, reduces plasma levels of platelet factor 4 and beta-thromboglobulin in patients in whom these proteins are elevated, and may also inhibit platelet adhesion, increase red cell filtrability and decrease whole blood viscosity.
Gene_expression (levels) of beta-thromboglobulin in blood associated with hemorrhage and adhesions
14) Confidence 0.44 Published 1987 Journal Drugs Section Abstract Doc Link 3304967 Disease Relevance 0.65 Pain Relevance 0.09
The disparity in angiogenic activity among CXC chemokine family members is attributed to three amino acid structural domains at the N terminus, Glu-Leu-Arg (ELR), which is present in angiogenic (i.e., CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL7, and CXCL8) [4-6], but not angiostatic (i.e., CXCL4, CXCL9, CXCL10, and CXCL11) CXC chemokines [7].
Gene_expression (present) of CXCL7 associated with chemokine
15) Confidence 0.39 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 0.71 Pain Relevance 0.27
CA patients showed increased basal levels of beta-thromboglobulin and thromboxane B2 compared to control patients and normal plasma levels of catecholamines.
Gene_expression (levels) of beta-thromboglobulin in plasma associated with angina and catecholamine
16) Confidence 0.30 Published 1995 Journal Pharmacol. Res. Section Abstract Doc Link 8668647 Disease Relevance 0.45 Pain Relevance 0.51
Plasma levels of the alpha-granule constituents beta-thromboglobulin and platelet factor 4 were measured in patients with sickle cell anemia during steady state and vaso-occlusive crisis in order to determine in vivo platelet activity.
Gene_expression (levels) of beta-thromboglobulin in Plasma associated with sickle cell anemia
17) Confidence 0.30 Published 1993 Journal Acta Haematol. Section Abstract Doc Link 8212998 Disease Relevance 0.44 Pain Relevance 0.07
Blood samples were obtained at several time points to determine platelet count, aggregation in response to adenosine diphosphate, and levels of beta-thromboglobulin, prothrombin fragment 1.2, and thrombin-antithrombin complex.
Gene_expression (levels) of beta-thromboglobulin in platelet
18) Confidence 0.26 Published 1999 Journal J. Thorac. Cardiovasc. Surg. Section Body Doc Link 10220694 Disease Relevance 0 Pain Relevance 0
Levels of plasma hemoglobin, beta-thromboglobulin, lactate dehydrogenase, and potassium remained constant before and after the perfusion and the control inflations.
Gene_expression (Levels) of beta-thromboglobulin in plasma
19) Confidence 0.24 Published 1987 Journal Circulation Section Abstract Doc Link 2955955 Disease Relevance 0.28 Pain Relevance 0.15
/CXCL1, connective tissue-activating peptide-III (CTAP-III)/CXCL7, granulocyte chemotactic protein-2/CXCL6, IP-10/CXCL10, PF4/CXCL4, monokine induced by IFN-?
Gene_expression (connective tissue) of CXCL7 in granulocyte
20) Confidence 0.24 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592799 Disease Relevance 0.44 Pain Relevance 0.64

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