INT90791

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Context Info
Confidence 0.44
First Reported 2000
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 2.94
Pain Relevance 2.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il10) extracellular region (Il10) intracellular (Il10)
Anatomy Link Frequency
macrophages 2
A20 2
Il10 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 129 100.00 Very High Very High Very High
Inflammation 123 100.00 Very High Very High Very High
adenocard 72 99.58 Very High Very High Very High
anesthesia 5 98.70 Very High Very High Very High
methotrexate 55 98.20 Very High Very High Very High
rheumatoid arthritis 6 97.36 Very High Very High Very High
Arthritis 9 92.88 High High
dexamethasone 9 90.40 High High
tolerance 1 88.88 High High
Morphine 4 78.04 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 137 100.00 Very High Very High Very High
Apoptosis 10 99.08 Very High Very High Very High
Rheumatoid Arthritis 6 97.36 Very High Very High Very High
Depression 2 94.40 High High
Arthritis 12 92.88 High High
Infection 93 91.28 High High
Targeted Disruption 54 85.36 High High
Disease 15 85.12 High High
Necrosis 6 65.84 Quite High
Cancer 6 65.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, to further assess the ability of M2 expression to up-regulate IL-10 secretion from B cells, we transfected the murine A20 B cell line with either a control expression vector (pIRES-EGFP) or an M2 expression vector (pM2-IEGFP) and assessed IL-10 secretion by ELISA (Figure 4F).
Regulation (regulate) of Localization (secretion) of IL-10 in A20
1) Confidence 0.44 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0 Pain Relevance 0.09
Heroin and M also had a highly stimulatory effect on the release of anti-inflammatory cytokines such as TGF-beta1 and IL-10, though this effect was observed after 120 min, peaking at 24 h and then somewhat decreasing at 48 h.
Regulation (effect) of Localization (release) of IL-10 associated with inflammation and cytokine
2) Confidence 0.39 Published 2000 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 10988355 Disease Relevance 0.39 Pain Relevance 0.68
In addition, these studies link M2 functional domains that play a critical role in MHV68 latency in vivo to M2-driven IL-10 secretion.
Regulation (role) of Localization (secretion) of IL-10
3) Confidence 0.23 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.24 Pain Relevance 0
D-PA failed to influence anti-OVA IgG, IgG2a and IgG1 production as well as IFN-gamma and IL-10 secretion.
Neg (failed) Regulation (influence) of Localization (secretion) of IL-10
4) Confidence 0.20 Published 2005 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 15698518 Disease Relevance 0.59 Pain Relevance 0.58
RTF is expressed on the surface of activated lymphocytes, constitutively expressed on macrophages and is thought to regulate both IL-10 secretion (Lee et al. [23]) and apoptosis (Boomer et al. [24]).
Regulation (regulate) of Localization (secretion) of IL-10 in macrophages associated with apoptosis
5) Confidence 0.18 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096758 Disease Relevance 0.34 Pain Relevance 0.09
Since adenosine receptor activation modulates the release of IL-10 by different inflammatory cells [25-27] and methotrexate-treated rheumatoid arthritis patients have shown increased serum levels of this cytokine [28,29], we determined whether constitutively or methotrexate-modified IL-10 accumulation in the inflammatory exudate was altered in adenosine receptor-deficient mice.
Spec (determined) Regulation (modulates) of Spec (determined) Localization (release) of IL-10 associated with adenocard, inflammation, rheumatoid arthritis, methotrexate and cytokine
6) Confidence 0.18 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526598 Disease Relevance 1.21 Pain Relevance 0.74
Surgery also contributes to the deviation of the immune response toward a Th2 and patients undergoing surgery and anesthesia have shown to present with down-regulated IL-2 secretion and up-regulated IL-10 and IL-4 secretion during the postoperative period.[34] However, in our study these confounding factors did not play much role as all patients underwent surgical procedures of almost similar duration, same type of anesthesia and single team of surgeons.
Regulation (regulated) of Localization (secretion) of IL-10 associated with anesthesia and cytokine
7) Confidence 0.17 Published 2010 Journal Asian Journal of Transfusion Science Section Body Doc Link PMC2937301 Disease Relevance 0.17 Pain Relevance 0.32

General Comments

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