INT9082

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Context Info
Confidence 0.69
First Reported 1980
Last Reported 2011
Negated 3
Speculated 9
Reported most in Abstract
Documents 238
Total Number 248
Disease Relevance 148.51
Pain Relevance 36.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ESR1) enzyme binding (ESR1) DNA binding (ESR1)
protein complex (ESR1) cytoplasm (ESR1) signal transduction (ESR1)
Anatomy Link Frequency
MCF-7 5
neurons 5
erythrocyte 4
blood 4
lymphocyte 3
ESR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 53 100.00 Very High Very High Very High
Inflammatory marker 34 100.00 Very High Very High Very High
cocaine 885 99.98 Very High Very High Very High
tramadol 125 99.98 Very High Very High Very High
Oxycodone 49 99.98 Very High Very High Very High
agonist 1066 99.96 Very High Very High Very High
antagonist 275 99.96 Very High Very High Very High
abdominal pain 39 99.96 Very High Very High Very High
Neurotransmitter 115 99.84 Very High Very High Very High
Pain 463 99.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
Breast Cancer 2802 100.00 Very High Very High Very High
Apoptosis 1505 100.00 Very High Very High Very High
Stress 817 100.00 Very High Very High Very High
INFLAMMATION 763 100.00 Very High Very High Very High
Obesity 551 100.00 Very High Very High Very High
Rheumatoid Arthritis 743 99.98 Very High Very High Very High
Fever 131 99.96 Very High Very High Very High
Abdominal Pain 39 99.96 Very High Very High Very High
Leukocytosis 10 99.96 Very High Very High Very High
Cancer 3358 99.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The estrogen receptor ER(alpha) and the estrogen receptor-regulated progesterone receptor and pS2 mRNA levels were increased by treatment with rotundifuran and agnuside within 24 h, and the effects could be reversed by ICI 182,780.
Positive_regulation (increased) of estrogen receptor
1) Confidence 0.69 Published 2007 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 17883902 Disease Relevance 0.07 Pain Relevance 0.12
His blood test disclosed positive inflammatory signs (i.e., mild elevation of ESR and positive CRP) without elevated value of muscle enzymes.
Positive_regulation (elevation) of ESR in blood associated with inflammation
2) Confidence 0.68 Published 1999 Journal Ryumachi Section Abstract Doc Link 10695407 Disease Relevance 1.09 Pain Relevance 0.19
Both ER and PR content were significantly elevated in the proliferative phase of the cycle.
Positive_regulation (elevated) of ER
3) Confidence 0.68 Published 1986 Journal Clin Physiol Biochem Section Abstract Doc Link 3709038 Disease Relevance 0.24 Pain Relevance 0.07
Increased serum alkaline phosphatase, LDH and ESR, and decreased peripheral lymphocyte count were frequently observed in the recurrent group.
Positive_regulation (Increased) of ESR in lymphocyte
4) Confidence 0.67 Published 1980 Journal Acta Obstet Gynaecol Jpn Section Abstract Doc Link 7211214 Disease Relevance 1.08 Pain Relevance 0.08
ESR and serum alkaline phosphatase levels were elevated in all but one subject.
Positive_regulation (elevated) of ESR
5) Confidence 0.67 Published 2001 Journal Neurol India Section Abstract Doc Link 11303239 Disease Relevance 1.74 Pain Relevance 0.14
Laboratory examination showed an elevated ESR and serum gamma-GT activity.
Positive_regulation (elevated) of ESR
6) Confidence 0.67 Published 1997 Journal Ned Tijdschr Geneeskd Section Abstract Doc Link 9157300 Disease Relevance 1.13 Pain Relevance 0.19
The laboratory data revealed 5.6 g of 24-hour urinary protein, increased ESR and CRP, a positive skin test for tuberculosis, and a positive culture fortuberculous bacilli from pleural effusion.
Positive_regulation (increased) of ESR in skin associated with pleural effusion and mycobacterial infection
7) Confidence 0.67 Published 2002 Journal Clin. Nephrol. Section Abstract Doc Link 11837803 Disease Relevance 1.02 Pain Relevance 0.13
C-reactive protein, ESR and plasma fibrinogen were markedly increased.
Positive_regulation (increased) of ESR in plasma
8) Confidence 0.67 Published 2002 Journal Dtsch. Med. Wochenschr. Section Body Doc Link 12098096 Disease Relevance 0.09 Pain Relevance 0
Clinical studies indicate that faecal Klebsiella can be isolated more readily from AS patients during active phases of the disease, when this is defined either clinically, with or without uveitis, or biochemically by elevation in ESR and C-reactive protein levels.
Positive_regulation (elevation) of ESR associated with spinal inflammation, uveitis and disease
9) Confidence 0.67 Published 1983 Journal Br. J. Rheumatol. Section Abstract Doc Link 6418259 Disease Relevance 0.80 Pain Relevance 0.60
The detection of vegetation during echocardiography, cardiac murmur during physical examination and the determination of increased ESR and CRP levels led to the diagnosis of endocarditis.
Positive_regulation (increased) of ESR associated with cv unclassified under development
10) Confidence 0.67 Published 2009 Journal Mikrobiyol Bul Section Abstract Doc Link 19334391 Disease Relevance 2.46 Pain Relevance 0.42
IL-6 is the major inducer of inflammatory responses against infection [15], thus TCZ could mask signs of infection such as fever, general malaise, and elevation of surrogate markers including CRP and ESR, and consequently make early diagnosis of infections more difficult.
Positive_regulation (elevation) of ESR associated with inflammatory response, fever and infection
11) Confidence 0.67 Published 2009 Journal Mod Rheumatol Section Body Doc Link PMC2720589 Disease Relevance 1.83 Pain Relevance 0.08
Laboratory evaluation revealed an increased ESR, hypergammaglobulinaemia, antinuclear antibodies, circulating immune complexes, complement consumption and elevated serum creatine kinase (CK) activity.
Positive_regulation (increased) of ESR
12) Confidence 0.67 Published 2001 Journal Clin. Rheumatol. Section Abstract Doc Link 11254243 Disease Relevance 0.45 Pain Relevance 0.13
In conclusion, we report the cases of two patients with large hemangiomas of the liver, abdominal pain, increased ESR and fibrinogen, increased serum alkaline phosphatase and gamma-glutamyltransferase activity, and normal white blood cell counts.
Positive_regulation (increased) of ESR in liver associated with abdominal pain and hemangioma
13) Confidence 0.67 Published 1991 Journal Dig. Dis. Sci. Section Abstract Doc Link 2007371 Disease Relevance 0.59 Pain Relevance 0.17
Increased ESR and fibrinogen are probably related to thrombosis within the tumor.
Positive_regulation (Increased) of ESR associated with cancer and thrombosis
14) Confidence 0.67 Published 1991 Journal Dig. Dis. Sci. Section Abstract Doc Link 2007371 Disease Relevance 0.70 Pain Relevance 0.17
AS patients with osteoporosis showed significantly increased CRP, ESR, cross-links and PTH and a significantly decreased 1.25 D3.
Positive_regulation (increased) of ESR associated with spinal inflammation and osteoporosis
15) Confidence 0.67 Published 2005 Journal Osteoporos Int Section Abstract Doc Link 16172800 Disease Relevance 1.75 Pain Relevance 0.68
mRNA transcript abundance and to examine their impact on transactivation of ER?
Spec (examine) Positive_regulation (transactivation) of ER
16) Confidence 0.64 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0 Pain Relevance 0
Yet this type of antagonist does not interfere with the activation function 1-mediated transactivation of ER?.
Positive_regulation (transactivation) of ER associated with antagonist
17) Confidence 0.64 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.21 Pain Relevance 0.12
abundance; in MDA-MB231 cells, their effects on cell-cycle arrest and apoptosis were closely accompanied by an induction of ER?
Positive_regulation (induction) of ER associated with apoptosis
18) Confidence 0.64 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.63 Pain Relevance 0
To examine whether decursin increased ER?
Spec (whether) Positive_regulation (increased) of ER
19) Confidence 0.64 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0 Pain Relevance 0.03
They included 257 genes upregulated in ER- ERBB2-amplified tumors and 145 upregulated in ER+ ERBB2-amplified tumors (corresponding to 366 and 272 probe sets, respectively) (Additionnal file 1-Table S7C).
Positive_regulation (upregulated) of ER associated with cancer
20) Confidence 0.64 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.80 Pain Relevance 0

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