INT90820

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Context Info
Confidence 0.24
First Reported 2000
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 7.64
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (MICA) plasma membrane (MICA) cytoplasm (MICA)
Anatomy Link Frequency
epithelial cells 2
lung 1
respiratory tract 1
MICA (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 32 67.64 Quite High
corticosteroid 10 56.96 Quite High
spinal inflammation 1 50.00 Quite Low
agonist 17 49.92 Quite Low
Inflammation 57 49.48 Quite Low
Multiple sclerosis 158 5.00 Very Low Very Low Very Low
Central nervous system 27 5.00 Very Low Very Low Very Low
cINOD 11 5.00 Very Low Very Low Very Low
Inflammatory response 9 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 33 100.00 Very High Very High Very High
Nicotine Addiction 455 99.52 Very High Very High Very High
Lung Cancer 10 99.06 Very High Very High Very High
Pulmonary Disease 435 99.00 Very High Very High Very High
Lower Respiratory Tract Infection 9 98.40 Very High Very High Very High
Conjunctivitis 56 98.00 Very High Very High Very High
Cancer 13 97.52 Very High Very High Very High
Infection 34 96.80 Very High Very High Very High
Eye Infections 24 90.40 High High
Viral Infection 7 89.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The NKG2 D ligands, MICA and B, are stress-inducible and primarily expressed on epithelial cells [32].
Gene_expression (expressed) of MICA in epithelial cells associated with stress
1) Confidence 0.24 Published 2010 Journal Respir Res Section Body Doc Link PMC2955660 Disease Relevance 0.75 Pain Relevance 0
In endobronchial biopsies and peripheral lung resection tissue from patients with lung cancer, Borchers et al found significantly increased expression of MICA in current smokers with COPD, compared to never smokers and former smokers with COPD.
Gene_expression (expression) of MICA in lung associated with pulmonary disease, nicotine addiction and lung cancer
2) Confidence 0.24 Published 2010 Journal Respir Res Section Body Doc Link PMC2955660 Disease Relevance 1.24 Pain Relevance 0.03
The activating function of NKG2 D is triggered by binding to MHC class 1 chain-related (MIC) molecules A and B, expressed on surface of stressed epithelial cells.
Gene_expression (expressed) of MHC class 1 chain-related in epithelial cells
3) Confidence 0.21 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2955660 Disease Relevance 0.69 Pain Relevance 0
There was no difference in epithelial CD4+ cells or MICA expression between the three groups, (figure 3 and 4).
Gene_expression (expression) of MICA
4) Confidence 0.19 Published 2010 Journal Respir Res Section Body Doc Link PMC2955660 Disease Relevance 1.57 Pain Relevance 0
MICA was not detectable in either BW or BAL.


Gene_expression (detectable) of MICA
5) Confidence 0.19 Published 2010 Journal Respir Res Section Body Doc Link PMC2955660 Disease Relevance 1.80 Pain Relevance 0
-UTR sequences and maintains expression of MICA and MICB protein under a certain threshold and facilitates acute upregulation of MICA and MICB during cellular stres [142].
Gene_expression (expression) of MICA
6) Confidence 0.12 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.60 Pain Relevance 0.03
No significant difference between HLA-B27+ patients with AS and healthy controls was found: the MICA-A4 allele was present in more than 90% of subjects.
Gene_expression (present) of MICA-A4
7) Confidence 0.10 Published 2000 Journal J. Rheumatol. Section Body Doc Link 10990233 Disease Relevance 0 Pain Relevance 0
The illustrative example of AUC0–24 h:MIC90 ratios demonstrates that AUC0–24 h:MIC90 ratios were low (ie, <2) for resistant Staphylococcus organisms, regardless of the fluoroquinolone.
Gene_expression (ratios) of MIC90
8) Confidence 0.09 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2861941 Disease Relevance 0.24 Pain Relevance 0
When AUC0–24 h:MIC90 ratios are calculated for the FQs against Staphylococcus organisms, besifloxacin has the greatest AUC0–24 h:MIC90 ratios and is the only FQ to achieve an AUC0–24 h:MIC90 ratio in excess of 100 for MSSA and MSSE (Figures 4 and 6).
Gene_expression (ratios) of MIC90
9) Confidence 0.09 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2861941 Disease Relevance 0.16 Pain Relevance 0
When AUC0–24 h:MIC90 ratios are calculated for the FQs against Staphylococcus organisms, besifloxacin has the greatest AUC0–24 h:MIC90 ratios and is the only FQ to achieve an AUC0–24 h:MIC90 ratio in excess of 100 for MSSA and MSSE (Figures 4 and 6).
Gene_expression (ratios) of MIC90
10) Confidence 0.09 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2861941 Disease Relevance 0.22 Pain Relevance 0
For example, a human study on respiratory tract infections caused by S. pneumoniae found that treatment with gatifloxacin at an AUC0–24 h:MIC90 ratio ?
Gene_expression (ratio) of MIC90 in respiratory tract associated with lower respiratory tract infection
11) Confidence 0.09 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2861941 Disease Relevance 0.37 Pain Relevance 0

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