INT90823

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Context Info
Confidence 0.59
First Reported 2000
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 25
Total Number 25
Disease Relevance 22.97
Pain Relevance 3.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Ptpn2) endoplasmic reticulum (Ptpn2) nucleus (Ptpn2)
cytoplasm (Ptpn2)
Anatomy Link Frequency
neurons 2
striatum 1
pore 1
midbrain 1
microglia 1
Ptpn2 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 293 100.00 Very High Very High Very High
midbrain 91 100.00 Very High Very High Very High
gABA 43 99.96 Very High Very High Very High
monoamine 29 99.68 Very High Very High Very High
cytokine 140 99.58 Very High Very High Very High
Inflammation 355 99.44 Very High Very High Very High
Nicotine 6 98.24 Very High Very High Very High
Substantia nigra 143 96.68 Very High Very High Very High
dopaminergic neurodegeneration 23 96.12 Very High Very High Very High
Kinase C 191 95.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Parkinson's Disease 1962 100.00 Very High Very High Very High
Disease 726 100.00 Very High Very High Very High
Stress 229 99.90 Very High Very High Very High
Cv Unclassified Under Development 354 99.52 Very High Very High Very High
INFLAMMATION 457 99.44 Very High Very High Very High
Drug Induced Neurotoxicity 189 99.44 Very High Very High Very High
Death 146 99.40 Very High Very High Very High
Apoptosis 114 98.96 Very High Very High Very High
Targeted Disruption 90 98.64 Very High Very High Very High
Neurodegenerative Disease 84 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, in MPTP-treated mice, 4-HNE fluorescence was increased significantly 24 h after the last injection of MPTP.
Positive_regulation (increased) of MPTP associated with parkinson's disease
1) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.70 Pain Relevance 0.12
We show for the first time a direct correlation between COX-2 and microglia activation in the mouse MPTP model.
Positive_regulation (activation) of MPTP in microglia associated with parkinson's disease
2) Confidence 0.50 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1440849 Disease Relevance 1.27 Pain Relevance 0.16
In mice drinking hydrogen water, the baseline level of 4-HNE fluorescence was unchanged, but the striking increase in fluorescence following MPTP administration was virtually annulled, to a level that was not significantly above baseline (Figure 6B).


Positive_regulation (increase) of MPTP associated with parkinson's disease
3) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.72 Pain Relevance 0.12
In the acute MPTP model, protein level of 4-HNE in midbrain is increased [12], [19].
Positive_regulation (increased) of MPTP in midbrain associated with parkinson's disease and midbrain
4) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.70 Pain Relevance 0.12
Mitochondrial 8-oxoG showed significant accumulation in the striatum 24 h after acute MPTP administration.
Positive_regulation (accumulation) of MPTP in striatum associated with parkinson's disease
5) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.84 Pain Relevance 0.07
HCT1026 inhibits MPTP-induced microglial activation
Positive_regulation (activation) of MPTP associated with parkinson's disease
6) Confidence 0.39 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.81 Pain Relevance 0.17
First, our own data using the mitochondrial 2-deoxyglucose entrapment technique failed to detect any increase in MPTP opening immediately following the preconditioning stimulus [68,75].
Positive_regulation (increase) of MPTP associated with parkinson's disease
7) Confidence 0.35 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.83 Pain Relevance 0.03
In MPTP mice fed with HCT1026, the mean latency to fall was significantly (p < 0.05) increased compared to MPTP mice fed with a control diet at all time tested.
Positive_regulation (increased) of MPTP associated with parkinson's disease
8) Confidence 0.34 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.91 Pain Relevance 0.13
As previously observed, a sharp increase of Mac-1 and PHOX followed MPTP treatment, as early as 1 dpt, in mice fed with the control diet, with levels remaining high at both 3 and 7 dpt (Figure 7A, B).
Positive_regulation (followed) of MPTP associated with parkinson's disease
9) Confidence 0.34 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.46 Pain Relevance 0.27
With the subchronic (administration of MPTP at 24-h interval, for 5 consecutive days) regimen, increasing the daily doses of MPTP resulted in a dose-dependent loss of DA uptake levels (Figure 1B).
Positive_regulation (increasing) of MPTP associated with parkinson's disease
10) Confidence 0.31 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.65 Pain Relevance 0
In the subchronic regimen, increasing doses of MPTP were administrated i.p. at 24-h interval, for 5 consecutive days and mice sacrificed 7 d post-treatment.
Positive_regulation (increasing) of MPTP associated with parkinson's disease
11) Confidence 0.31 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 1.09 Pain Relevance 0.03
Conversely, blocking the action of endogenous anti-inflammatory molecules, such as glucocorticoid hormones in transgenic mice expressing a glucocorticoid receptor (GR) antisense RNA, sharply increases microglial activation in response to MPTP, resulting in increased DAergic neuron vulnerability [8,10,11].
Positive_regulation (activation) of MPTP in neuron associated with parkinson's disease, targeted disruption and inflammation
12) Confidence 0.31 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 1.51 Pain Relevance 0.62
Nicotine is an antioxidant (Ferger et al. 1998) and is an inhibitor of monoamine oxidase B that activates MPTP neuorotoxicity (Yong and Perry 1986).
Positive_regulation (activates) of MPTP associated with parkinson's disease, nicotine and monoamine
13) Confidence 0.26 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1280408 Disease Relevance 0.92 Pain Relevance 0.23
By contrast, our own direct measurements [68] and those of others [73] do not support MPTP opening in ischaemia.
Neg (not) Positive_regulation (support) of MPTP associated with parkinson's disease and cv unclassified under development
14) Confidence 0.25 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 1.36 Pain Relevance 0
Mitochondria isolated at the end of ischaemia, or during reperfusion, were more sensitive to calcium-induced MPTP opening than those isolated prior to ischaemia.
Positive_regulation (induced) of MPTP associated with parkinson's disease and cv unclassified under development
15) Confidence 0.25 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 1.18 Pain Relevance 0
Animal studies also demonstrate that the pesticides, paraquat and rotenone, which are chemically similar to the established DA neurotoxin, MPTP, can reliably induce PD-like pathology, and hence, are becoming widely used to produce a parkinsonian syndrome in animals.
Positive_regulation (established) of MPTP associated with parkinson's disease, dopamine, parkinsonian disorders and disease
16) Confidence 0.24 Published 2011 Journal Parkinson's Disease Section Body Doc Link PMC3018622 Disease Relevance 1.10 Pain Relevance 0.20
and PKG (see Section 6) may converge on one or more of these steps to decrease ROS levels and hence reduce activation of the MPTP by thiol oxidation.
Positive_regulation (activation) of MPTP associated with parkinson's disease
17) Confidence 0.24 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.67 Pain Relevance 0.05
This will then activate further pore opening in the same mitochondrion since MPTP opening of calcium loaded mitochondria is activated by depolarisation [42].
Positive_regulation (activated) of MPTP in pore associated with parkinson's disease
18) Confidence 0.24 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.52 Pain Relevance 0
Inversely, it was shown that MPTP sensitivity is increased in some lines of alpha-synuclein transgenic mice (Nieto et al., 2006; Yu et al., 2008).
Positive_regulation (increased) of MPTP associated with targeted disruption and parkinson's disease
19) Confidence 0.19 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 1.10 Pain Relevance 0.05
They found that modafinil reduced striatal GABA, increased the levels of reduced glutathione in MPTP damaged neurons, and reduced levels of the lipid peroxidation product malodialdehyde.
Positive_regulation (increased) of MPTP in neurons associated with parkinson's disease and gaba
20) Confidence 0.13 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654794 Disease Relevance 0.86 Pain Relevance 0.32

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