INT90825

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Context Info
Confidence 0.17
First Reported 2000
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 4.13
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NFKBIB) signal transduction (NFKBIB) nucleus (NFKBIB)
cytoplasm (NFKBIB) signal transducer activity (NFKBIB)
Anatomy Link Frequency
microglia 2
mononuclear cells 1
NFKBIB (Homo sapiens)
Pain Link Frequency Relevance Heat
Substantia nigra 4 100.00 Very High Very High Very High
Inflammation 107 99.40 Very High Very High Very High
cytokine 44 98.88 Very High Very High Very High
antagonist 4 92.60 High High
Calcium channel 2 92.12 High High
agonist 2 89.64 High High
Dopamine 2 89.28 High High
Inflammatory response 21 81.04 Quite High
tolerance 2 73.88 Quite High
dopaminergic neurodegeneration 2 71.92 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 144 99.40 Very High Very High Very High
Cancer 36 98.44 Very High Very High Very High
Necrosis 4 98.16 Very High Very High Very High
Aging 29 90.96 High High
Diabetes Mellitus 16 89.52 High High
Obesity 17 88.72 High High
Stress 11 85.80 High High
Overnutrition 3 82.96 Quite High
Parkinson's Disease 4 77.92 Quite High
Disease 73 77.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This expresses itself as proliferation of activated microglia in the substantia nigra, activation and translocation of transcription factors and neurotrophic factor (NF), kappa-beta and elevation of cytotoxic cytokines, tumour necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6.
Gene_expression (expresses) of kappa-beta in microglia associated with necrosis, cancer, substantia nigra and cytokine
1) Confidence 0.17 Published 2000 Journal J. Neurol. Section Abstract Doc Link 10991672 Disease Relevance 1.19 Pain Relevance 0.54
This expresses itself as proliferation of activated microglia in the substantia nigra, activation and translocation of transcription factors and neurotrophic factor (NF), kappa-beta and elevation of cytotoxic cytokines, tumour necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6.
Gene_expression (proliferation) of kappa-beta in microglia associated with necrosis, cancer, substantia nigra and cytokine
2) Confidence 0.17 Published 2000 Journal J. Neurol. Section Abstract Doc Link 10991672 Disease Relevance 1.18 Pain Relevance 0.54
In fact, insulin reduces ROS generation by mononuclear cells, suppresses NADPH oxidase expression and intranuclear NF-kB binding, induces IkB expression and suppresses some inflammatory molecules [69,76].
Gene_expression (expression) of IkB in mononuclear cells associated with inflammation
3) Confidence 0.09 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1166571 Disease Relevance 1.76 Pain Relevance 0.32

General Comments

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