INT90826

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Context Info
Confidence 0.17
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.01
Pain Relevance 1.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (NFASC) plasma membrane (NFASC)
Anatomy Link Frequency
epithelial cells 1
microglia 1
NFASC (Homo sapiens)
Pain Link Frequency Relevance Heat
Substantia nigra 2 99.66 Very High Very High Very High
cytokine 81 98.36 Very High Very High Very High
Inflammation 147 96.24 Very High Very High Very High
peptic ulcer disease 1 95.76 Very High Very High Very High
rheumatoid arthritis 180 95.24 Very High Very High Very High
Arthritis 164 93.36 High High
antagonist 1 88.72 High High
Calcium channel 1 88.24 High High
agonist 1 85.76 High High
Dopamine 1 85.40 High High
Disease Link Frequency Relevance Heat
Infection 21 100.00 Very High Very High Very High
Cancer 22 97.92 Very High Very High Very High
Necrosis 29 97.64 Very High Very High Very High
Stomach Cancer 1 97.52 Very High Very High Very High
INFLAMMATION 171 96.24 Very High Very High Very High
Disease 53 95.76 Very High Very High Very High
Ulcers 1 95.44 Very High Very High Very High
Rheumatoid Arthritis 180 95.24 Very High Very High Very High
Gastritis 3 94.76 High High
Arthritis 115 93.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This expresses itself as proliferation of activated microglia in the substantia nigra, activation and translocation of transcription factors and neurotrophic factor (NF), kappa-beta and elevation of cytotoxic cytokines, tumour necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6.
Localization (translocation) of NF in microglia associated with necrosis, cancer, substantia nigra and cytokine
1) Confidence 0.17 Published 2000 Journal J. Neurol. Section Abstract Doc Link 10991672 Disease Relevance 1.11 Pain Relevance 0.53
Type II NF is far less common than type I infection and tends to occur in otherwise healthy, young, immunocompetent hosts and is classically located on the extremities.
Localization (located) of NF associated with infection
2) Confidence 0.06 Published 2009 Journal Scand J Trauma Resusc Emerg Med Section Body Doc Link PMC2704167 Disease Relevance 1.20 Pain Relevance 0
for degradation, releasing NF-?
Localization (releasing) of NF
3) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779420 Disease Relevance 0.78 Pain Relevance 0.31
Selective pharmacological NF-?
Localization (Selective) of NF
4) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779420 Disease Relevance 0.80 Pain Relevance 0.40
as readout for NF-?
Localization (readout) of NF
5) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779420 Disease Relevance 0.25 Pain Relevance 0.13
Evaluation of NF-?
Localization (Evaluation) of NF
6) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779420 Disease Relevance 0.18 Pain Relevance 0.09
Our results indicate that the NBD peptide may have great potential in humans as well, because this NF-?
Localization (because) of NF
7) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779420 Disease Relevance 0.97 Pain Relevance 0.42
We have previously shown that H. pylori-induced NF-(kappa)B activation and interleukin (IL)-8 secretion are mediated by Toll-like receptor (TLR) 2 in epithelial cells.
Localization (secretion) of NF in epithelial cells
8) Confidence 0.02 Published 2005 Journal Helicobacter Section Abstract Doc Link 15904477 Disease Relevance 0.71 Pain Relevance 0.10

General Comments

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