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Context Info
Confidence 0.40
First Reported 2000
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.75
Pain Relevance 1.22

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transmembrane transporter activity (SLC22A6) plasma membrane (SLC22A6) protein complex (SLC22A6)
transmembrane transport (SLC22A6)
SLC22A6 (Homo sapiens)
Pain Link Frequency Relevance Heat
methotrexate 9 99.54 Very High Very High Very High
Inflammation 1 95.68 Very High Very High Very High
cINOD 11 94.80 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 5 95.68 Very High Very High Very High
Disease 1 74.24 Quite High
Nephrotoxicity 2 66.68 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 63.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Diflunisal, ketoprofen, flurbiprofen, indomethacin, naproxen, and ibuprofen were equally or more effective (IC(50) = 0.85-8 microM) than probenecid or betamipron, two known potent inhibitors of hOAT1 (IC(50) = 8 and 6 microM, respectively) with in vivo nephroprotective effects.
Negative_regulation (inhibitors) of hOAT1
1) Confidence 0.40 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10991954 Disease Relevance 0.41 Pain Relevance 0.54
These findings suggest that loxoprofen retards the elimination of methotrexate, at least in part, by inhibiting hOAT1 and hOAT3.
Negative_regulation (inhibiting) of hOAT1 associated with methotrexate
2) Confidence 0.39 Published 2004 Journal Drug Metab. Pharmacokinet. Section Abstract Doc Link 15548848 Disease Relevance 0.14 Pain Relevance 0.49
Several OA, including probenecid, inhibited OAT1.
Negative_regulation (inhibited) of OAT1
3) Confidence 0.35 Published 2003 Journal Rev. Physiol. Biochem. Pharmacol. Section Abstract Doc Link 12605306 Disease Relevance 0.19 Pain Relevance 0.19

General Comments

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