INT90829

Context Info Confidence 0.40 First Reported 2000 Last Reported 2004 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 0.75 Pain Relevance 1.22

transmembrane transporter activity (SLC22A6) plasma membrane (SLC22A6) protein complex (SLC22A6) transmembrane transport (SLC22A6)

SLC22A6 (Homo sapiens)

Pain Link Frequency Relevance Heat methotrexate 9 99.54 Inflammation 1 95.68 cINOD 11 94.80

Disease Link Frequency Relevance Heat INFLAMMATION 5 95.68 Disease 1 74.24 Nephrotoxicity 2 66.68 Acquired Immune Deficiency Syndrome Or Hiv Infection 4 63.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Diflunisal, ketoprofen, flurbiprofen, indomethacin, naproxen, and ibuprofen were equally or more effective (IC(50) = 0.85-8 microM) than probenecid or betamipron, two known potent inhibitors of hOAT1 (IC(50) = 8 and 6 microM, respectively) with in vivo nephroprotective effects.

Negative_regulation (inhibitors) of hOAT1

1) Confidence 0.40 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10991954 Disease Relevance 0.41 Pain Relevance 0.54

These findings suggest that loxoprofen retards the elimination of methotrexate, at least in part, by inhibiting hOAT1 and hOAT3.

Negative_regulation (inhibiting) of hOAT1 associated with methotrexate

2) Confidence 0.39 Published 2004 Journal Drug Metab. Pharmacokinet. Section Abstract Doc Link 15548848 Disease Relevance 0.14 Pain Relevance 0.49

Several OA, including probenecid, inhibited OAT1.

Negative_regulation (inhibited) of OAT1

3) Confidence 0.35 Published 2003 Journal Rev. Physiol. Biochem. Pharmacol. Section Abstract Doc Link 12605306 Disease Relevance 0.19 Pain Relevance 0.19

General Comments

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