INT9083

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Context Info
Confidence 0.78
First Reported 1991
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 74
Total Number 80
Disease Relevance 70.96
Pain Relevance 12.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Nppb) extracellular region (Nppb) nucleus (Nppb)
cytoplasm (Nppb)
Anatomy Link Frequency
plasma 10
brain 8
ventricles 4
urine 4
head 3
Nppb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 62 100.00 Very High Very High Very High
Spinal cord 15 99.96 Very High Very High Very High
Calcitonin gene-related peptide 6 99.84 Very High Very High Very High
dorsal root ganglion 6 99.68 Very High Very High Very High
rheumatoid arthritis 629 99.20 Very High Very High Very High
anesthesia 25 99.16 Very High Very High Very High
Angina 149 98.36 Very High Very High Very High
Inflammation 211 98.12 Very High Very High Very High
ischemia 140 98.12 Very High Very High Very High
cva 155 97.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Myocardial Infarction 1919 100.00 Very High Very High Very High
Natriuresis 938 100.00 Very High Very High Very High
Pulmonary Hypertension 299 100.00 Very High Very High Very High
Neck Pain 40 100.00 Very High Very High Very High
Obesity 684 99.90 Very High Very High Very High
Diabetes Mellitus 88 99.88 Very High Very High Very High
Disease 691 99.84 Very High Very High Very High
Pulmonary Disease 285 99.84 Very High Very High Very High
Heart Disease 68 99.62 Very High Very High Very High
Renal Disease 291 99.50 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the spinal cord, BNP was also shown to be present as BNP-45, but its concentration was only 0.057 pmol/g, being about 1/60 that of spinal cord ANP.
Gene_expression (present) of BNP-45 in spinal cord associated with spinal cord
1) Confidence 0.78 Published 1991 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 2043123 Disease Relevance 0.24 Pain Relevance 0.48
However, recent data from the ICON study group have shown that despite a decreased production of NT-proBNP in obese subjects, NT-proBNP keeps its diagnostic capabilities across all BMI categories.
Gene_expression (production) of NT-proBNP associated with obesity
2) Confidence 0.78 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 1.16 Pain Relevance 0
An important consideration in patients with pulmonary disease is involvement of the right ventricle as a consequence of their pulmonary disease: since NT-proBNP is produced everywhere cardiomyocytes are present it is well known that cardiomyocytes in the right ventricle produce NT-proBNP to a meaningful degree, particularly when stretched.67 Therefore, although the concentrations are usually lower, NT-proBNP can be elevated in with patients with increased right ventricular pressures, such as in pulmonary embolism (PE) or pulmonary arterial hypertension (PAH).38,68 In patients with PE, echocardiographic studies have confirmed that NT-proBNP concentrations correlate with echocardiographic and invasive measured parameters of right ventricular dysfunction.68–70 Also, Kucher et al. have shown that elevated concentrations of NT-proBNP correlate with adverse clinical outcome in patients with PE,71 which makes NT-proBNP not only a predictor of prognosis in these patients, but also a potential tool in therapy decision making (i.e. which patient should receive thrombolytic therapy).
Gene_expression (produced) of NT-proBNP in ventricle associated with pulmonary embolism, pulmonary hypertension, pulmonary disease, right ventricular dysfunction and cva
3) Confidence 0.78 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 1.89 Pain Relevance 0.16
Immunohistochemistry showed that BNP was expressed in calcitonin gene-related peptide (CGRP)-containing small neurons and IB4 (isolectin B4)-positive neurons, whereas NPR-A was present in CGRP-containing neurons.
Gene_expression (expressed) of BNP in neurons associated with calcitonin gene-related peptide
4) Confidence 0.76 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20702721 Disease Relevance 0.89 Pain Relevance 0.63
Using microarray and immunoblot analyses, we found that BNP and NPR-A were expressed in the dorsal root ganglion (DRG) of rats and upregulated after intraplantar injection of complete Freund's adjuvant (CFA).
Gene_expression (expressed) of BNP in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
5) Confidence 0.76 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20702721 Disease Relevance 0.85 Pain Relevance 0.53
In the spinal cord, BNP was also shown to be present as BNP-45, but its concentration was only 0.057 pmol/g, being about 1/60 that of spinal cord ANP.
Gene_expression (present) of BNP in spinal cord associated with spinal cord
6) Confidence 0.68 Published 1991 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 2043123 Disease Relevance 0.24 Pain Relevance 0.49
This also confirmed by the renal clearance studies of BNP and NT-proBNP in several population with moderate renal impairment.94–96 In addition, Tsutamoto and colleagues compared NT-proBNP and BNP production with serum concentrations by sampling in the aortic root and the coronary sinus, and they found that there was no decrease in clearance until GFR was <40 ml/min.
Gene_expression (production) of NT-proBNP in coronary sinus
7) Confidence 0.68 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 0.47 Pain Relevance 0
This also confirmed by the renal clearance studies of BNP and NT-proBNP in several population with moderate renal impairment.94–96 In addition, Tsutamoto and colleagues compared NT-proBNP and BNP production with serum concentrations by sampling in the aortic root and the coronary sinus, and they found that there was no decrease in clearance until GFR was <40 ml/min.
Gene_expression (production) of BNP in coronary sinus
8) Confidence 0.68 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 0.46 Pain Relevance 0
Following weight-loss surgery, postoperative BMI decreased dramatically in the study subjects, with parallel rise in both NT-proBNP and BNP over time.86 Importantly, BNP and NT-proBNP production in obese subjects is suppressed in the face of higher levels of ventricular wall stress than in non-obese patients.
Gene_expression (production) of NT-proBNP in face associated with stress and obesity
9) Confidence 0.68 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 1.42 Pain Relevance 0
Following weight-loss surgery, postoperative BMI decreased dramatically in the study subjects, with parallel rise in both NT-proBNP and BNP over time.86 Importantly, BNP and NT-proBNP production in obese subjects is suppressed in the face of higher levels of ventricular wall stress than in non-obese patients.
Gene_expression (production) of BNP in face associated with stress and obesity
10) Confidence 0.68 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 1.42 Pain Relevance 0
(Fig. 3) Besides, a subanalysis of this study also confirmed that NT-proBNP is not only diagnostic in systolic HF, but is also diagnostic in diastolic HF.36
Gene_expression (diagnostic) of NT-proBNP associated with myocardial infarction
11) Confidence 0.67 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 1.29 Pain Relevance 0
(Fig. 3) Besides, a subanalysis of this study also confirmed that NT-proBNP is not only diagnostic in systolic HF, but is also diagnostic in diastolic HF.36
Gene_expression (diagnostic) of NT-proBNP associated with myocardial infarction
12) Confidence 0.67 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 1.27 Pain Relevance 0
While NT-proBNP is thought to be inert without any physiological function, BNP is biologically active and is responsible for several compensatory mechanisms in HF such as an increase of urine production and sodium excretion, a decrease of the aldosterone level, a lowering of the blood pressure and a lowering of the pulmonary capillary wedge pressure.17,18 BNP in physiological concentrations has too little effect to restore euvolemia but BNP is studied as a potential therapeutic agent in HF.19–22
Gene_expression (thought) of NT-proBNP in urine associated with myocardial infarction
13) Confidence 0.67 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 0.39 Pain Relevance 0
While NT-proBNP is thought to be inert without any physiological function, BNP is biologically active and is responsible for several compensatory mechanisms in HF such as an increase of urine production and sodium excretion, a decrease of the aldosterone level, a lowering of the blood pressure and a lowering of the pulmonary capillary wedge pressure.17,18 BNP in physiological concentrations has too little effect to restore euvolemia but BNP is studied as a potential therapeutic agent in HF.19–22
Neg (without) Gene_expression (inert) of NT-proBNP in urine associated with myocardial infarction
14) Confidence 0.67 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 0.39 Pain Relevance 0
To obtain background data on plasma ANP and BNP levels in rats, we investigated the circadian rhythms and effects of anesthesia on these peptides.
Gene_expression (levels) of BNP in plasma associated with anesthesia
15) Confidence 0.67 Published 2009 Journal Yakugaku Zasshi Section Abstract Doc Link 19952533 Disease Relevance 0.54 Pain Relevance 0.41
The plasma ANP and BNP levels were determined using a radioimmunoassay.
Gene_expression (levels) of BNP in plasma
16) Confidence 0.67 Published 2009 Journal Yakugaku Zasshi Section Abstract Doc Link 19952533 Disease Relevance 0.48 Pain Relevance 0.45
This proBNP108 is enzymatically cleaved immediately in a 1:1 ratio to yield BNP (32 amino acids) and NT-proBNP (76 amino acids) which are directly released into the circulation.14 (Fig. 2) Interestingly, not all the proBNP produced in the cardiomyocytes is cleft since intact proBNP108 is measured in the circulation as well.15 Schellenberger et al. also report the presence of small amounts of glycosylated proBNP in the circulation, which is typically of much larger molecular weight.16 Athough proBNP108 is known to be detected by all BNP and NT-proBNP assays, whether glycosylated proBNP108 has any effect on conventional assays for natriuretic peptides is still not known.
Gene_expression (produced) of NT-proBNP in cardiomyocytes associated with natriuresis
17) Confidence 0.60 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 0.36 Pain Relevance 0.04
A recent study has shown that serum concentrations of N-terminal pro-brain natriuretic peptide (NT-proBNP), a hormone produced by the cardiac ventricles in response to stretch and elevated in cardiac failure, are correlated with levels of inflammatory markers and disease activity in RA, and higher than matched controls3.
Gene_expression (produced) of NT-proBNP in brain associated with natriuresis, inflammatory marker, rheumatoid arthritis, disease and heart failure
18) Confidence 0.60 Published 2010 Journal Ulster Med J Section Body Doc Link PMC2993131 Disease Relevance 2.08 Pain Relevance 0.50
Plasma levels of BNP have been found to increase during hypoxia.[20] In addition to extended exposure to hypobaric hypoxia itself (10-91 days), endurance training in hypobaric hypoxic conditions leads to a marked early increase in ventricular and atrial BNP mRNA levels.[21] As for the physiologic effects that can be produced by elevated plasma BNP levels, Klinger et al., found that in rats, BNP infusion attenuated the development of hypoxic pulmonary hypertension.[22] The authors suggested that this finding supports the hypothesis that endogenous BNP plays a role in modulating the pulmonary hypertensive responses seen in chronic hypoxia.
Gene_expression (produced) of BNP in plasma associated with pulmonary hypertension and hypoxia
19) Confidence 0.59 Published 2010 Journal Indian Journal of Ophthalmology Section Body Doc Link PMC2886248 Disease Relevance 1.30 Pain Relevance 0
Fernández-Durango showed that intracamerally injected BNP stimulated guanylate cyclase activity and decreased IOP.[16] Under chronic hypoxic conditions, plasma levels of BNP have been found to increase.[20] In addition to extended exposure to hypobaric hypoxia itself (10-91 days), endurance training in hypobaric hypoxic conditions leads to a marked early increase in ventricular and atrial BNP mRNA levels.[21] As for the physiologic effects that can be produced by elevated plasma BNP levels, Klinger et al., found that in rats, BNP infusion attenuated the development of hypoxic pulmonary hypertension.[22] The authors suggested that this finding supports the hypothesis that endogenous BNP plays a role in modulating the pulmonary hypertensive responses seen in chronic hypoxia.
Gene_expression (produced) of BNP in plasma associated with pulmonary hypertension, hypoxia and ocular hypertension
20) Confidence 0.59 Published 2010 Journal Indian Journal of Ophthalmology Section Body Doc Link PMC2886248 Disease Relevance 1.57 Pain Relevance 0

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