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Context Info
Confidence 0.69
First Reported 2000
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.86
Pain Relevance 0.89

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transmembrane transporter activity (SLC22A6) plasma membrane (SLC22A6) protein complex (SLC22A6)
transmembrane transport (SLC22A6)
Anatomy Link Frequency
renal proximal tubules 1
SLC22A6 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 11 99.68 Very High Very High Very High
methotrexate 9 99.12 Very High Very High Very High
Inflammation 1 81.68 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 5 99.48 Very High Very High Very High
Nephrotoxicity 2 90.60 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 87.40 High High
Disease 1 79.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Human organic anion transporters hOAT1 (SLC22A6) and hOAT3 (SLC22A8) are responsible for renal tubular secretion of an antifolic acid methotrexate, and are considered to be involved in drug interaction of methotrexate with nonsteroidal anti-inflammatory drugs (NSAIDs).
Localization (secretion) of hOAT1 associated with inflammation, cinod and methotrexate
1) Confidence 0.69 Published 2004 Journal Drug Metab. Pharmacokinet. Section Abstract Doc Link 15548848 Disease Relevance 0.17 Pain Relevance 0.47
It has been recently shown that adefovir is efficiently transported by the human renal organic anion transporter 1 (hOAT1), a membrane transport protein localized in the kidney, that presumably mediates the accumulation of adefovir in renal proximal tubules.
Localization (localized) of hOAT1 in renal proximal tubules
2) Confidence 0.65 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10991954 Disease Relevance 0.50 Pain Relevance 0.24
OAT1 translocated, e.g., anti-inflammatory drugs, antiviral drugs, beta-lactam antibiotics, loop diuretics, ochratoxin A, and p-aminohippurate.
Localization (translocated) of OAT1 associated with inflammation and cinod
3) Confidence 0.42 Published 2003 Journal Rev. Physiol. Biochem. Pharmacol. Section Abstract Doc Link 12605306 Disease Relevance 0.18 Pain Relevance 0.18

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