INT90849

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Context Info
Confidence 0.78
First Reported 2000
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 55
Total Number 57
Disease Relevance 31.31
Pain Relevance 20.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (F2rl1) signal transducer activity (F2rl1)
Anatomy Link Frequency
neurons 13
mast cell 8
colon 4
dorsal root ganglia 4
visceral 2
F2rl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 581 99.90 Very High Very High Very High
dorsal root ganglion 256 99.82 Very High Very High Very High
Hyperalgesia 62 99.76 Very High Very High Very High
Pain 92 99.72 Very High Very High Very High
nMDA receptor 132 99.46 Very High Very High Very High
Central nervous system 5 99.28 Very High Very High Very High
Neuropeptide 31 99.20 Very High Very High Very High
Root ganglion neuron 3 99.16 Very High Very High Very High
nud 400 99.08 Very High Very High Very High
Kinase C 3 98.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 549 99.90 Very High Very High Very High
Nociception 143 99.84 Very High Very High Very High
Ganglion Cysts 260 99.82 Very High Very High Very High
Hyperalgesia 73 99.76 Very High Very High Very High
Pain 92 99.72 Very High Very High Very High
Stress 842 99.34 Very High Very High Very High
Dyspepsia 400 99.08 Very High Very High Very High
Neuropathic Pain 40 98.56 Very High Very High Very High
Hypersensitivity 111 98.44 Very High Very High Very High
Inflammatory Pain 6 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Proteinase-activated receptor 2 (PAR-2) is expressed on many nociceptive neurons.
Gene_expression (expressed) of Proteinase-activated receptor 2 in neurons associated with nociception
1) Confidence 0.78 Published 2004 Journal Neuroreport Section Abstract Doc Link 15486484 Disease Relevance 0.19 Pain Relevance 0.62
Proteinase-activated receptor 2 (PAR-2) is expressed on many nociceptive neurons.
Gene_expression (expressed) of PAR-2 in neurons associated with nociception
2) Confidence 0.78 Published 2004 Journal Neuroreport Section Abstract Doc Link 15486484 Disease Relevance 0.19 Pain Relevance 0.62
It has been reported that proteinase-activated receptor 2 (PAR2) receptor activation enhances the animal's pain response and PAR2 coexpresses with P2X3 in dorsal root ganglion neurons.
Gene_expression (coexpresses) of PAR2 in neurons associated with ganglion cysts, pain and root ganglion neuron
3) Confidence 0.77 Published 2010 Journal Neuroreport Section Abstract Doc Link 20118742 Disease Relevance 0.41 Pain Relevance 0.32
Protease-activated receptor-2 (PAR-2), expressed in sensory neurons, triggers thermal hyperalgesia, nociceptive behavior and spinal Fos expression in rats.
Gene_expression (expressed) of Protease-activated receptor-2 in spinal associated with nociception and thermal hyperalgesia
4) Confidence 0.77 Published 2002 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 12120762 Disease Relevance 0.58 Pain Relevance 0.49
Protease-activated receptor-2 (PAR-2), expressed in sensory neurons, triggers thermal hyperalgesia, nociceptive behavior and spinal Fos expression in rats.
Gene_expression (expressed) of PAR-2 in spinal associated with nociception and thermal hyperalgesia
5) Confidence 0.77 Published 2002 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 12120762 Disease Relevance 0.58 Pain Relevance 0.49
Stress-induced Alterations in Mast Cell Numbers and Proteinase-activated Receptor-2 Expression of the Colon: Role of Corticotrophin-releasing Factor

This study was performed in order to assess whether acute stress can increase mast cell and enterochromaffin (EC) cell numbers, and proteinase-activated receptor-2 (PAR2) expression in the rat colon.

Gene_expression (expression) of proteinase-activated receptor-2 in colon associated with stress
6) Confidence 0.76 Published 2010 Journal Journal of Korean Medical Science Section Title Doc Link PMC2923781 Disease Relevance 0.35 Pain Relevance 0
PAR2 is highly expressed in the intestine, where it is found in colonic myocytes, enterocytes, enteric neurons, terminals of mesenteric afferent nerves, and immune cells (25, 26).
Gene_expression (expressed) of PAR2 in intestine
7) Confidence 0.76 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923781 Disease Relevance 0.98 Pain Relevance 0.61
with anti-chromogranin A antibodies for EC cells and to anti-PAR2 antibodies for PAR2 protein expression.
Gene_expression (expression) of PAR2
8) Confidence 0.76 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923781 Disease Relevance 0 Pain Relevance 0
We speculate that a 90 min restraint session permits the release of CRF, which is able to increase mast cells and PAR2 expression in the colon.
Gene_expression (expression) of PAR2 in mast cells
9) Confidence 0.76 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923781 Disease Relevance 1.15 Pain Relevance 0.79
In mice, colonic exposure to supernatants from diarrhea-predominant IBS patients results in allodynia and increased colonic paracellular permeability, which is dependent on PAR2 expression (30).
Gene_expression (expression) of PAR2 associated with diarrhoea, allodynia and spastic colon
10) Confidence 0.76 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923781 Disease Relevance 1.10 Pain Relevance 0.74
In conclusion, acute stress in rats increases mast cell numbers and mucosal PAR2 expression in the colon.
Gene_expression (expression) of PAR2 in colon associated with stress
11) Confidence 0.76 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923781 Disease Relevance 1.05 Pain Relevance 0.66
Acute stress in rats increases mast cell numbers and mucosal PAR2 expression in the colon.
Gene_expression (expression) of PAR2 in mast cell associated with stress
12) Confidence 0.76 Published 2010 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2923781 Disease Relevance 0.29 Pain Relevance 0
Stress-induced Alterations in Mast Cell Numbers and Proteinase-activated Receptor-2 Expression of the Colon: Role of Corticotrophin-releasing Factor

This study was performed in order to assess whether acute stress can increase mast cell and enterochromaffin (EC) cell numbers, and proteinase-activated receptor-2 (PAR2) expression in the rat colon.

Gene_expression (expression) of PAR2 in colon associated with stress
13) Confidence 0.76 Published 2010 Journal Journal of Korean Medical Science Section Title Doc Link PMC2923781 Disease Relevance 0.35 Pain Relevance 0
Thus, it is plausible that CRF released during acute stress increases mast cell numbers and degranulates mast cells, which upregulates PAR2 expression in the colon.
Gene_expression (expression) of PAR2 in colon associated with stress
14) Confidence 0.76 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923781 Disease Relevance 0.98 Pain Relevance 0.56
The results of the present study confirmed that PAR2 expression was significantly increased by stress.
Gene_expression (expression) of PAR2 associated with stress
15) Confidence 0.76 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923781 Disease Relevance 0.88 Pain Relevance 0.57
Using immunohistochemistry, we showed that many P2X3s are co-expressed with the PAR2 in rat dorsal root ganglia neurons.
Gene_expression (expressed) of PAR2 in dorsal root ganglia
16) Confidence 0.76 Published 2006 Journal Neuroreport Section Abstract Doc Link 16951565 Disease Relevance 0.19 Pain Relevance 0.55
MATERIALS AND METHODS: We examined the expression of PAR2 to 4 in bladder urothelium and detrusor muscle whole mounts in controls, female rats and those treated with cyclophosphamide (CYP) acutely (4 and 48 hours) or chronically (every third day for 10 days) using Western blot and immunohistochemical techniques.
Spec (examined) Gene_expression (expression) of PAR2 in bladder
17) Confidence 0.75 Published 2005 Journal J. Urol. Section Body Doc Link 15643279 Disease Relevance 0.19 Pain Relevance 0
RESULTS: Proteinase-activated receptor 2 was expressed by virtually all nociceptive neurons in thoracic dorsal root ganglia.
Gene_expression (expressed) of Proteinase-activated receptor 2 in neurons
18) Confidence 0.74 Published 2004 Journal Gastroenterology Section Body Doc Link 15362043 Disease Relevance 0.15 Pain Relevance 0
In conclusion, our study demonstrates expression of PAR-2 in rat pancreatic acini as well as parotid acini and indicates that nitric oxide participates in the PAR-2-mediated in vivo secretion of pancreatic amylase, and, to a certain extent, of salivary amylase, although capsaicin-sensitive sensory neurons, known to be activated by PAR-2, are not involved in the evoked pancreatic or salivary amylase secretion.
Gene_expression (expression) of PAR-2 in sensory neurons associated with qutenza
19) Confidence 0.67 Published 2002 Journal Life Sci. Section Abstract Doc Link 12231404 Disease Relevance 0 Pain Relevance 0.26
Immunohistochemical analyses using the polyclonal antibody against rat PAR-2 clearly showed abundant expression of PAR-2 in rat pancreatic and parotid acini.
Gene_expression (expression) of PAR-2
20) Confidence 0.67 Published 2002 Journal Life Sci. Section Abstract Doc Link 12231404 Disease Relevance 0 Pain Relevance 0.08

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