INT9085

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Context Info
Confidence 0.81
First Reported 1991
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 32
Total Number 32
Disease Relevance 15.10
Pain Relevance 3.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Nppb) extracellular region (Nppb) nucleus (Nppb)
cytoplasm (Nppb)
Anatomy Link Frequency
cardiomyocytes 5
cardiocytes 4
heart 4
brain 3
ventricles 2
Nppb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 21 99.84 Very High Very High Very High
Morphine 10 99.76 Very High Very High Very High
anesthesia 20 98.56 Very High Very High Very High
Intracerebroventricular 1 96.96 Very High Very High Very High
fibrosis 1 95.52 Very High Very High Very High
Spinal cord 10 94.72 High High
Angina 85 94.16 High High
Inflammation 14 91.92 High High
Catecholamine 1 89.32 High High
Arthritis 5 88.84 High High
Disease Link Frequency Relevance Heat
Natriuresis 230 100.00 Very High Very High Very High
Cv Unclassified Under Development 58 100.00 Very High Very High Very High
Systemic Sclerosis 20 99.70 Very High Very High Very High
Left Ventricular Dysfunction 11 99.08 Very High Very High Very High
Hypertension 13 98.72 Very High Very High Very High
Pulmonary Hypertension 45 98.24 Very High Very High Very High
Death 77 98.16 Very High Very High Very High
Heart Rate Under Development 32 98.08 Very High Very High Very High
Hypoxia 9 97.52 Very High Very High Very High
Myocardial Infarction 357 97.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine stimulates secretion of ANP and BNP but by different ratios, suggesting different regulation systems for storage and secretion of ANP and BNP.
Localization (secretion) of BNP associated with morphine
1) Confidence 0.81 Published 1991 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 2043123 Disease Relevance 0.22 Pain Relevance 0.45
Morphine stimulates secretion of ANP and BNP but by different ratios, suggesting different regulation systems for storage and secretion of ANP and BNP.
Localization (secretion) of BNP associated with morphine
2) Confidence 0.81 Published 1991 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 2043123 Disease Relevance 0.22 Pain Relevance 0.46
This proBNP108 is enzymatically cleaved immediately in a 1:1 ratio to yield BNP (32 amino acids) and NT-proBNP (76 amino acids) which are directly released into the circulation.14 (Fig. 2) Interestingly, not all the proBNP produced in the cardiomyocytes is cleft since intact proBNP108 is measured in the circulation as well.15 Schellenberger et al. also report the presence of small amounts of glycosylated proBNP in the circulation, which is typically of much larger molecular weight.16 Athough proBNP108 is known to be detected by all BNP and NT-proBNP assays, whether glycosylated proBNP108 has any effect on conventional assays for natriuretic peptides is still not known.
Localization (released) of NT-proBNP in cardiomyocytes associated with natriuresis
3) Confidence 0.80 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 0.30 Pain Relevance 0.04
Rat brain natriuretic peptide is localized in atrial granules and released into the circulation.
Localization (localized) of brain natriuretic peptide in brain associated with natriuresis
4) Confidence 0.70 Published 1992 Journal Am. J. Physiol. Section Title Doc Link 1387295 Disease Relevance 0.29 Pain Relevance 0.07
Rat brain natriuretic peptide is localized in atrial granules and released into the circulation.
Localization (released) of brain natriuretic peptide in brain associated with natriuresis
5) Confidence 0.70 Published 1992 Journal Am. J. Physiol. Section Title Doc Link 1387295 Disease Relevance 0.29 Pain Relevance 0.07
Double-labeling immunocytochemical methods colocalized BNP and ANF in the same atrial secretory granules.
Localization (colocalized) of BNP
6) Confidence 0.70 Published 1992 Journal Am. J. Physiol. Section Abstract Doc Link 1387295 Disease Relevance 0.24 Pain Relevance 0.09
B-type natriuretic peptide (BNP) has been known to be secreted from cardiac myocytes and activate its receptor, natriuretic peptide receptor-A (NPR-A), to reduce ventricular fibrosis.
Localization (secreted) of BNP in cardiac myocytes associated with natriuresis and fibrosis
7) Confidence 0.69 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20702721 Disease Relevance 0.73 Pain Relevance 0.32
This proBNP108 is enzymatically cleaved immediately in a 1:1 ratio to yield BNP (32 amino acids) and NT-proBNP (76 amino acids) which are directly released into the circulation.14 (Fig. 2) Interestingly, not all the proBNP produced in the cardiomyocytes is cleft since intact proBNP108 is measured in the circulation as well.15 Schellenberger et al. also report the presence of small amounts of glycosylated proBNP in the circulation, which is typically of much larger molecular weight.16 Athough proBNP108 is known to be detected by all BNP and NT-proBNP assays, whether glycosylated proBNP108 has any effect on conventional assays for natriuretic peptides is still not known.
Localization (released) of BNP in cardiomyocytes associated with natriuresis
8) Confidence 0.65 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 0.30 Pain Relevance 0.04
Indeed, a small study by Allonore et al. performed in 40 patients with systemic sclerosis suggests that NT-proBNP can be used as a screening tool for the early stage of PAH, when clinical symptoms are not present yet.73

NT-proBNP and Obesity

Localization (used) of NT-proBNP associated with pulmonary hypertension, obesity and systemic sclerosis
9) Confidence 0.65 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 1.77 Pain Relevance 0.04
However, after adjusting for these confounding factors, we found that the prognostic value of BNP and hsCRP were still statistically significant.
Localization (value) of BNP
10) Confidence 0.65 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2628862 Disease Relevance 0.50 Pain Relevance 0.07
These observations indicate that AVP, AII and ET-1 stimulate the release of ir-BNP (probably rat BNP-45) through a change in blood pressure.
Localization (release) of BNP-45 in blood associated with cv unclassified under development
11) Confidence 0.64 Published 1992 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 1526063 Disease Relevance 0.23 Pain Relevance 0
However, when corrected for these factors in multivariate analysis, NT-proBNP remains an independent predictor.108 Secondly, other studies found elevations of BNP correlate with the size of ischemic myocardium, which is not necessarily stretch related;111,112 as well, recent studies from the stress testing literature show unequivocal evidence for elevations in both NT-proBNP and BNP in patients with ischemia but with normal LV function.113,114 Finally, Goetze et al. found in vitro, that the secretion of NT-proBNP in ischemia is mediated by a different pathway, triggered by hypoxia rather than myocardial stretch.115,116 Accordingly, in addition to valuable risk stratification in identifying those with an ACS on top of a dysfunctional ventricle, NT-proBNP levels may also reflect degree and extent of myocardial ischemia.
Localization (secretion) of NT-proBNP in ventricle associated with stress, acute coronary syndrome, coronary artery disease, hypoxia and ischemia
12) Confidence 0.62 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 1.14 Pain Relevance 0.21
BNP and its cleavage equivalent NT-proBNP have emerged as superior markers for left-ventricular dysfunction, because when cardiomyocytes are stretched, these peptides are rapidly expressed at gene level and immediately released into the circulation.
Localization (released) of NT-proBNP in cardiomyocytes associated with cv unclassified under development
13) Confidence 0.62 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 0.79 Pain Relevance 0.03
The increased long-term mortality was associated with elevated BNP concentrations, pointing to the need for further investigations into the underlying pathomechanisms of BNP release.
Localization (release) of BNP
14) Confidence 0.62 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2628862 Disease Relevance 0.50 Pain Relevance 0.15
Depending on the stimulus, BNP release into the circulation is not necessarily proportional to ANF, indicating that BNP may originate not only from the atrial granules but also from other tissues such as the ventricles.
Localization (release) of BNP in ventricles
15) Confidence 0.61 Published 1992 Journal Am. J. Physiol. Section Abstract Doc Link 1387295 Disease Relevance 0.21 Pain Relevance 0.09
Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are circulating hormones secreted predominantly in patients with hypertension or congestive heart failure.
Neg (failure) Localization (secreted) of BNP in heart associated with natriuresis, heart rate under development and hypertension
16) Confidence 0.61 Published 2009 Journal Yakugaku Zasshi Section Abstract Doc Link 19952533 Disease Relevance 0.54 Pain Relevance 0.36
Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are circulating hormones secreted predominantly in patients with hypertension or congestive heart failure.
Neg (failure) Localization (secreted) of brain natriuretic peptide in heart associated with natriuresis, heart rate under development and hypertension
17) Confidence 0.61 Published 2009 Journal Yakugaku Zasshi Section Abstract Doc Link 19952533 Disease Relevance 0.55 Pain Relevance 0.36
Serum for hsCRP and EDTA plasma for BNP were immediately frozen and stored at -80°C until the measurements were performed.
Localization (Serum) of BNP in plasma
18) Confidence 0.57 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2628862 Disease Relevance 0.37 Pain Relevance 0.18
These observations indicate that AVP, AII and ET-1 stimulate the release of ir-BNP (probably rat BNP-45) through a change in blood pressure.
Localization (release) of BNP in blood associated with cv unclassified under development
19) Confidence 0.56 Published 1992 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 1526063 Disease Relevance 0.23 Pain Relevance 0
ET-1 clearly stimulated the secretion of ir-BNP in both atrial and ventricular cardiocytes.
Localization (secretion) of BNP in cardiocytes
20) Confidence 0.56 Published 1992 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 1526063 Disease Relevance 0.22 Pain Relevance 0

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