INT90852

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Context Info
Confidence 0.78
First Reported 2000
Last Reported 2010
Negated 3
Speculated 3
Reported most in Body
Documents 26
Total Number 48
Disease Relevance 5.50
Pain Relevance 4.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (F2r) signal transducer activity (F2r)
Anatomy Link Frequency
urothelial cells 5
skeletal muscle 4
blood 3
myoblasts 2
uterus 2
F2r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
lidocaine 198 100.00 Very High Very High Very High
agonist 134 100.00 Very High Very High Very High
Inflammation 526 99.68 Very High Very High Very High
Somatosensory cortex 2 99.32 Very High Very High Very High
tetrodotoxin 28 99.30 Very High Very High Very High
Glutamate 18 98.40 Very High Very High Very High
Inflammatory stimuli 110 95.96 Very High Very High Very High
Kinase C 4 93.12 High High
nociceptor 3 90.16 High High
cytokine 110 89.40 High High
Disease Link Frequency Relevance Heat
Multiple Organ Failure 36 100.00 Very High Very High Very High
Hemorrhage 32 100.00 Very High Very High Very High
INFLAMMATION 629 99.68 Very High Very High Very High
Infection 3 98.74 Very High Very High Very High
Cancer 91 98.40 Very High Very High Very High
Necrosis 8 98.16 Very High Very High Very High
Nociception 2 97.08 Very High Very High Very High
Peripheral Arterial Disease 22 87.12 High High
Cystitis 88 86.44 High High
Disease 4 86.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of the thrombin receptor (PAR-1) during rat skeletal muscle differentiation.
Gene_expression (Expression) of PAR-1 in skeletal muscle
1) Confidence 0.78 Published 2001 Journal J. Cell. Physiol. Section Title Doc Link 11598900 Disease Relevance 0 Pain Relevance 0.09
Blockade of contractile activity by tetrodotoxin (TTX, 6 nM) did not modify either PAR-1 synthesis or its cellular localization.
Gene_expression (synthesis) of PAR-1 associated with tetrodotoxin
2) Confidence 0.78 Published 2001 Journal J. Cell. Physiol. Section Abstract Doc Link 11598900 Disease Relevance 0 Pain Relevance 0.15
Expression of the thrombin receptor (PAR-1) during rat skeletal muscle differentiation.
Gene_expression (Expression) of thrombin in skeletal muscle
3) Confidence 0.78 Published 2001 Journal J. Cell. Physiol. Section Title Doc Link 11598900 Disease Relevance 0 Pain Relevance 0.09
CONCLUSIONS: We confirmed that thrombin and thrombin produced by actively clotting blood had a robust uterotonic effect in the rat and that prostaglandin production did not play a significant role in thrombin-stimulated contractions.


Gene_expression (produced) of thrombin in blood
4) Confidence 0.78 Published 2001 Journal J. Soc. Gynecol. Investig. Section Body Doc Link 11677145 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: We confirmed that thrombin and thrombin produced by actively clotting blood had a robust uterotonic effect in the rat and that prostaglandin production did not play a significant role in thrombin-stimulated contractions.


Gene_expression (produced) of thrombin in blood
5) Confidence 0.78 Published 2001 Journal J. Soc. Gynecol. Investig. Section Body Doc Link 11677145 Disease Relevance 0 Pain Relevance 0
Expression of PAR1-4 receptors has also been reported for an additional human urothelial cancer cell line (J82) however, receptor functionality was not investigated [21].
Gene_expression (Expression) of PAR1 in J82 associated with cancer
6) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0.35 Pain Relevance 0.19
In addition, we document that UROtsa cells express MIF and we show, using dual-immunofluorescence that UROtsa cells can express PAR1 and MIF simultaneously.
Gene_expression (express) of PAR1
7) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0.37 Pain Relevance 0.10
MIF and PAR1 expression was examined in normal human immortalized urothelial cells (UROtsa) using real-time RT-PCR, Western blotting and dual immunostaining.
Spec (examined) Gene_expression (expression) of PAR1 in urothelial cells
8) Confidence 0.75 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3013117 Disease Relevance 0.27 Pain Relevance 0.28
Given that both human and rat urothelial cells were shown to express both MIF and PAR1 we consider it likely that thrombin stimulated PAR1 receptors on rat urothelial cells to elicit MIF release.
Gene_expression (express) of PAR1 in urothelial cells
9) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0.07 Pain Relevance 0.03
Taken together, these results suggest that PAR-1 expression is not related to contractile activity but to myogenic differentiation.
Gene_expression (expression) of PAR-1
10) Confidence 0.67 Published 2001 Journal J. Cell. Physiol. Section Abstract Doc Link 11598900 Disease Relevance 0 Pain Relevance 0.12
Its specific receptor "protease activated receptor-1" (PAR-1), a G protein-coupled receptor, has been shown to be expressed in myoblasts but not after fusion (Suidan et al., 1996 J Biol Chem 271:29162-29169).
Neg (not) Gene_expression (expressed) of PAR-1 in myoblasts
11) Confidence 0.67 Published 2001 Journal J. Cell. Physiol. Section Abstract Doc Link 11598900 Disease Relevance 0 Pain Relevance 0.03
Investigation of PAR-1 on rat muscle cryostat sections at Day 18 of embryogenesis and postnatal Days 1, 5, and 10 indicated that this protein is first expressed in the cytoplasm and that it later localizes to the membrane.
Gene_expression (expressed) of PAR-1 in muscle
12) Confidence 0.67 Published 2001 Journal J. Cell. Physiol. Section Abstract Doc Link 11598900 Disease Relevance 0 Pain Relevance 0.14
In the present work we have investigated the expression of PAR-1 during rat skeletal muscle differentiation both in vitro and in vivo.
Spec (investigated) Gene_expression (expression) of PAR-1 in skeletal muscle
13) Confidence 0.67 Published 2001 Journal J. Cell. Physiol. Section Abstract Doc Link 11598900 Disease Relevance 0 Pain Relevance 0.08
Primary cultures of rat foetal skeletal muscle, characterized by their spontaneous contractile activity, were used for exploration of PAR-1 by RT-PCR, immunocytochemistry and Western blotting.
Gene_expression (exploration) of PAR-1 in skeletal muscle
14) Confidence 0.67 Published 2001 Journal J. Cell. Physiol. Section Abstract Doc Link 11598900 Disease Relevance 0 Pain Relevance 0.11
However, considerable heterogeneity of PAR1 immunostaining was observed with some cells showing intense PAR1 immunostaining while other cells were devoid of PAR1 or MIF immunostaining (Fig. 2C; arrows).
Gene_expression (devoid) of PAR1
15) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0 Pain Relevance 0
Cells that showed PAR1 immunostaining also displayed MIF immunostaining (Fig. 2C).
Gene_expression (immunostaining) of PAR1
16) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0 Pain Relevance 0
Although local thrombin formation during inflammation is likely to occur in the suburothelial compartment and thus stimulate basal and intermediate cells to elicit MIF release, our findings suggest that proteases present in the urine may also be able to activate PAR1 receptors in the urothelium, elicit MIF release and thus contribute to the initiation or maintenance of cystitis.
Gene_expression (formation) of thrombin in urine associated with inflammation and cystitis
17) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0.30 Pain Relevance 0.17
6/group) and 0.3 ml of either 1) sterile saline (vehicle control); 2) 100 nM thrombin; or 3) 2% lidocaine +100 nM thrombin were injected into the bladder lumen.
Gene_expression (injected) of thrombin in lumen associated with lidocaine
18) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0.16 Pain Relevance 0.31
No PAR1 immunostaining was observed in umbrella cells.
Gene_expression (immunostaining) of PAR1
19) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0.14 Pain Relevance 0.03
We examined PAR1 and MIF immunostaining in UROtsa cells and rat urothelium using scanning laser confocal dual immunofluorescence.
Spec (examined) Gene_expression (immunostaining) of PAR1
20) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0 Pain Relevance 0

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