INT90865

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Context Info
Confidence 0.23
First Reported 2000
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.26
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Scly) cytoplasm (Scly)
Anatomy Link Frequency
skin 1
parasympathetic 1
Scly (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 246 100.00 Very High Very High Very High
depression 67 100.00 Very High Very High Very High
Demyelination 6 91.96 High High
lidocaine 2 86.04 High High
sodium channel 1 79.36 Quite High
Biofeedback 4 78.24 Quite High
Face pain 1 73.84 Quite High
anesthesia 4 50.00 Quite Low
alcohol 7 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Demyelinating Disease 252 100.00 Very High Very High Very High
Depression 68 100.00 Very High Very High Very High
Autoimmune Disease 2 99.56 Very High Very High Very High
Peripheral Arterial Disease 6 98.78 Very High Very High Very High
Stress 1 92.00 High High
Mental Disorders 73 91.12 High High
Anxiety Disorder 38 80.20 Quite High
Bruxism 1 75.00 Quite High
Facial Neuralgia 1 74.20 Quite High
Disease 46 63.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Still, applying both may yield more complete information because SCL is mainly sensitive to the pathological part of the affectivity distribution, whereas the SWB scores are sensitive also to the happy part of the distribution.
Regulation (sensitive) of SCL associated with depression
1) Confidence 0.23 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2936431 Disease Relevance 1.01 Pain Relevance 0.20
No existing correlations for changes in SCL and EMG-activity could be established.
Regulation (changes) of SCL
2) Confidence 0.21 Published 2001 Journal J Oral Rehabil Section Abstract Doc Link 11580823 Disease Relevance 0.15 Pain Relevance 0.22
However, network studies based on the quantitative expression levels of 20 genes in over one hundred individuals identify jagged-1 as a new therapeutic target whose differential behavior in the MScl network was not modified by immunomodulatory therapy, illustrating how network analysis can predict therapeutic targets for immune intervention and identifying the immunomodulatory properties of jagged-1, making it a new therapeutic target for MScl and other autoimmune diseases [26].
Regulation (target) of MScl associated with multiple sclerosis and autoimmune disease
3) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 0.93 Pain Relevance 0.39
However, network studies based on the quantitative expression levels of 20 genes in over one hundred individuals identify jagged-1 as a new therapeutic target whose differential behavior in the MScl network was not modified by immunomodulatory therapy, illustrating how network analysis can predict therapeutic targets for immune intervention and identifying the immunomodulatory properties of jagged-1, making it a new therapeutic target for MScl and other autoimmune diseases [26].
Neg (not) Regulation (modified) of MScl associated with multiple sclerosis and autoimmune disease
4) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 0.83 Pain Relevance 0.34
The effect of the group assignment on parental heart rate (HR), parental blood pressure, and parental skin conductance level (SCL) were assessed.
Regulation (effect) of SCL in skin
5) Confidence 0.06 Published 2003 Journal Anesthesiology Section Body Doc Link 12502980 Disease Relevance 0.09 Pain Relevance 0
These results suggest that parasympathetic ganglionic cells in the SVC-Ao fat pad, differing from those in SA and AV fat pads, nonselectively control the atrial contractile force, SCL, and AV conduction partially in the dog heart.
Spec (partially) Regulation (control) of SCL in parasympathetic associated with peripheral arterial disease
6) Confidence 0.02 Published 2000 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 10993785 Disease Relevance 0.25 Pain Relevance 0.20

General Comments

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