INT90875

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.42
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 31
Total Number 31
Disease Relevance 26.22
Pain Relevance 2.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CCND1) nucleoplasm (CCND1) nucleus (CCND1)
intracellular (CCND1) enzyme binding (CCND1) cell division (CCND1)
Anatomy Link Frequency
endothelial cells 1
liver 1
CCND1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 148 99.16 Very High Very High Very High
aspirin 10 98.96 Very High Very High Very High
Analgesic 3 98.96 Very High Very High Very High
Inflammation 150 98.24 Very High Very High Very High
COX-2 inhibitor 108 89.44 High High
cINOD 62 87.32 High High
palliative 4 84.72 Quite High
agonist 113 80.20 Quite High
Arthritis 1 72.20 Quite High
Rheumatism 1 71.76 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 812 99.90 Very High Very High Very High
Non-small-cell Lung Cancer 52 99.82 Very High Very High Very High
Lymphatic System Cancer 50 99.60 Very High Very High Very High
Metastasis 228 99.56 Very High Very High Very High
Cancer 2160 99.28 Very High Very High Very High
Colon Cancer 145 99.22 Very High Very High Very High
Retinoblastoma 7 98.64 Very High Very High Very High
INFLAMMATION 175 98.24 Very High Very High Very High
Breast Cancer 366 96.84 Very High Very High Very High
Carcinoma 35 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The S phase block was accompanied by a reduction in the protein levels of cyclin A, cyclin B1, cyclin D1, cdc2, PCNA and the c-jun AP-1 component.
Negative_regulation (reduction) of cyclin D1
1) Confidence 0.42 Published 2003 Journal Int. J. Cancer Section Abstract Doc Link 14566835 Disease Relevance 0.53 Pain Relevance 0.06
Salicylate-induced growth arrest is associated with inhibition of p70s6k and down-regulation of c-myc, cyclin D1, cyclin A, and proliferating cell nuclear antigen.
Negative_regulation (inhibition) of cyclin D1 associated with analgesic
2) Confidence 0.41 Published 2000 Journal J. Biol. Chem. Section Title Doc Link 10993886 Disease Relevance 0.27 Pain Relevance 0.34
Western blot analysis showed a decrease in cyclin D1 and an increase in p21 and p27, indicating that the mechanism of this growth inhibition is cell cycle arrest.
Negative_regulation (decrease) of cyclin D1
3) Confidence 0.41 Published 2007 Journal J. Gastrointest. Surg. Section Abstract Doc Link 17874277 Disease Relevance 1.14 Pain Relevance 0.08
This is associated with phosphorylation of the protein VASP, a marker of PKG activation, activation of JNK1 and a decrease in cellular levels of cyclin D1; effects seen with other agents that cause activation of PKG in these cells.
Negative_regulation (decrease) of cyclin D1
4) Confidence 0.34 Published 2008 Journal Mol. Carcinog. Section Abstract Doc Link 18163459 Disease Relevance 0.38 Pain Relevance 0.27
Recently, Barbash et al140 demonstrated that attenuation of cyclin D1 SCFFbx4 E3 ubiquitin ligase activity occurs frequently in human cancer and may represent a common mechanism of overexpression and deregulation of cyclin D1.
Negative_regulation (attenuation) of cyclin D1 associated with cancer
5) Confidence 0.32 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.71 Pain Relevance 0
While extracts of P. decumanum showed only moderate anti-cancer activity and were therefore not further analysed, particularly the dichloromethane extract of P. odorata inhibited the cell cycle in G2-M which correlated with the activation of checkpoint kinase 2, and down-regulation of Cdc25A and cyclin D1 as well as inactivation of Erk1/2.
Negative_regulation (regulation) of cyclin D1 associated with cancer
6) Confidence 0.31 Published 2009 Journal Int. J. Oncol. Section Abstract Doc Link 19287970 Disease Relevance 1.26 Pain Relevance 0.25
However, apart from its role in cell cycle transitions, CCND1 is also a potent inhibitor of AR activity [46].
Negative_regulation (inhibitor) of CCND1
7) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0 Pain Relevance 0
The short-lived cyclin D1 was decreased by cycloheximide to below the detection level (Figure 5b, lanes 5–8), affirming the effectiveness of cycloheximide to block protein synthesis.
Negative_regulation (decreased) of cyclin D1
8) Confidence 0.23 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0 Pain Relevance 0
This supports the theory of a damaged regulatory pathway wherein p16 predominantly inhibits cyclin-D1 associated kinase activities [48].
Negative_regulation (inhibits) of cyclin-D1
9) Confidence 0.23 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2913917 Disease Relevance 0.91 Pain Relevance 0
The inhibition of cyclin D1-CDK4/6 complex activity prevents retinoblastoma protein phosphorylation and release of E2F, leading to the inhibition of cell cycle in G1/S transition [3].
Negative_regulation (inhibition) of cyclin D1 associated with retinoblastoma
10) Confidence 0.20 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1185532 Disease Relevance 0.86 Pain Relevance 0
Treatment with lovastatin or celecoxib decreased the levels of cyclin D1, CDK2, pRb and E2F1, while the combination treatment showed more pronounced suppression.
Negative_regulation (decreased) of cyclin D1
11) Confidence 0.19 Published 2009 Journal Int. J. Oncol. Section Abstract Doc Link 19787257 Disease Relevance 0.33 Pain Relevance 0.07
modifications observed in different studies (decrease in cyclin D1, inhibition
Negative_regulation (decrease) of cyclin D1
12) Confidence 0.18 Published 2008 Journal PPAR Research Section Body Doc Link PMC2464819 Disease Relevance 0.84 Pain Relevance 0
BRCA1 could be characterized as having a basal phenotype, ER-negative and HER2-negative, with up-regulation of cyclin A and caspase 3, but downregulation of cyclin D1 and D3, CDKIs (p16, p21, p27), and BCL2, the opposite phenotype from most BRCA2 carcinomas.
Negative_regulation (downregulation) of cyclin D1 associated with carcinoma
13) Confidence 0.15 Published 2006 Journal Proteome Sci Section Body Doc Link PMC1456950 Disease Relevance 1.12 Pain Relevance 0.20
This effect was associated with a reduction of cyclin D level, a key protein involved in G1-S transition [54], and PCNA, thus increasing the processivity of DNA polymerase [82].
Negative_regulation (reduction) of cyclin D
14) Confidence 0.15 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.63 Pain Relevance 0.13
with 15d-PGJ2 induced MCL cell apoptosis and downregulated cyclin D1
Negative_regulation (downregulated) of cyclin D1 associated with lymphatic system cancer and apoptosis
15) Confidence 0.15 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 2.15 Pain Relevance 0
Capsaicin-induced G1 arrest is correlated with the suppression of cyclin D1 levels, inhibition of cdk4 activity and Rb phosphorylation in endothelial and breast cancer cells [21], [22].
Negative_regulation (suppression) of cyclin D1 associated with qutenza and breast cancer
16) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 1.08 Pain Relevance 0.72
of caspase 3 and inhibition of cyclin D1 by the combination was not reversed by
Negative_regulation (inhibition) of cyclin D1
17) Confidence 0.12 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 1.15 Pain Relevance 0.18
Our RT-PCR results showed downregulation of cyclin D1 and c-myc in the tumors treated with the combination therapy.
Negative_regulation (downregulation) of cyclin D1 associated with cancer
18) Confidence 0.12 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2777152 Disease Relevance 0.99 Pain Relevance 0
In our study, downregulation of EGFR also resulted in reduction of cyclin D1.
Negative_regulation (reduction) of cyclin D1
19) Confidence 0.12 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2777152 Disease Relevance 1.08 Pain Relevance 0
Moreover, the inhibition of cell proliferation was correlated to a downregulation of cyclin D1, cyclin E, and pRb and the upregulation of p16 and p27 [89].
Negative_regulation (downregulation) of cyclin D1
20) Confidence 0.11 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.97 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox