INT9089

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Context Info
Confidence 0.69
First Reported 1989
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 7.09
Pain Relevance 2.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ceacam1) cell adhesion (Ceacam1) plasma membrane (Ceacam1)
Anatomy Link Frequency
spinal 2
Plasma 1
external 1
Ceacam1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spinal inflammation 19 99.84 Very High Very High Very High
Pain 72 99.14 Very High Very High Very High
Action potential 69 90.88 High High
imagery 55 90.40 High High
agonist 8 86.24 High High
Inflammation 44 86.16 High High
endometriosis 5 81.60 Quite High
spondylitis 1 79.12 Quite High
cINOD 12 73.20 Quite High
Dismenorea 2 70.12 Quite High
Disease Link Frequency Relevance Heat
Syndrome 12 99.96 Very High Very High Very High
Low Back Pain 20 99.84 Very High Very High Very High
Pain 55 99.14 Very High Very High Very High
Metabolic Bone Disease 1 98.96 Very High Very High Very High
Osteomyelitis 95 98.32 Very High Very High Very High
Osteoporosis 24 98.28 Very High Very High Very High
Hypercalcemia 13 97.16 Very High Very High Very High
Cancer 6 97.16 Very High Very High Very High
Body Weight 10 96.48 Very High Very High Very High
Metastasis 7 95.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Circulating osteocalcin (BGP), the major noncollagenous bone protein, is elevated in patients with certain metabolic bone disease while its behavior in cancer patients, particularly those with bone metastases, is unclear.
Positive_regulation (elevated) of osteocalcin associated with metabolic bone disease, cancer and metastasis
1) Confidence 0.69 Published 1989 Journal Cancer Invest. Section Abstract Doc Link 2630006 Disease Relevance 0.78 Pain Relevance 0
In women, osteocalcin level increased after the age of 50 years and was higher than in men.
Positive_regulation (increased) of osteocalcin
2) Confidence 0.69 Published 1990 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 2247770 Disease Relevance 0.17 Pain Relevance 0.07
Osteocalcin was elevated in 34% of patients, but was not associated with disease activity or BMD.
Positive_regulation (elevated) of Osteocalcin
3) Confidence 0.69 Published 2005 Journal J. Rheumatol. Section Body Doc Link 15996067 Disease Relevance 0.05 Pain Relevance 0
These data show that clodronate provided pain relief in 75% of treated patients and the increase in circulating osteocalcin levels can be considered a marker of the stabilization of skeletal metastatic lesions.
Positive_regulation (increase) of osteocalcin associated with pain
4) Confidence 0.41 Published 1992 Journal Anticancer Drugs Section Abstract Doc Link 1388063 Disease Relevance 0.62 Pain Relevance 0.25
Osteocalcin was present in concentration similar to that previously reported (5) and concentration was upregulated by addition of vitamin D to the culture medium (Table 1).


Positive_regulation (upregulated) of Osteocalcin
5) Confidence 0.41 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2782207 Disease Relevance 0.16 Pain Relevance 0.09
Vitamin D and osteocalcin were consistently increased in the CsA and CsA/FB groups.
Positive_regulation (increased) of osteocalcin
6) Confidence 0.39 Published 1996 Journal Bone Section Abstract Doc Link 8894144 Disease Relevance 0.22 Pain Relevance 0.06
The contribution of ecto-nucleotidases to the degradation of ATP within the isolated rat spinal roots was tested bymeans of inhibitors of such enzymes (Figure 6a,b).
Positive_regulation (contribution) of ecto-nucleotidases in spinal
7) Confidence 0.35 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096649 Disease Relevance 0 Pain Relevance 0
Osteocalcin levels were significantly higher in AS patients in comparison with control subjects (p < 0.05).
Positive_regulation (higher) of Osteocalcin associated with spinal inflammation
8) Confidence 0.33 Published 2001 Journal J Clin Rheumatol Section Abstract Doc Link 17039162 Disease Relevance 1.58 Pain Relevance 0.80
The possible importance of ecto-nucleotidases for the decline of the ATP concentration after compression-induced release was tested in another series of experiments.
Spec (possible) Positive_regulation (importance) of ecto-nucleotidases
9) Confidence 0.30 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096649 Disease Relevance 0 Pain Relevance 0
The importance of ecto-nucleotidases for the recovery period was determined by exposure of isolated spinal roots to high concentrations of ATP and by use of inhibitors of ecto-nucleotidases.
Positive_regulation (importance) of ecto-nucleotidases in spinal
10) Confidence 0.30 Published 2006 Journal Purinergic Signal Section Abstract Doc Link PMC2096649 Disease Relevance 0.14 Pain Relevance 0.15
Although we do not define it as a form of chemosensory adaptation, responsiveness to external ATP and GTP is also affected by the presence of externally facing ecto-ATPases which can hydrolyze these compounds and inactivate the depolarizing stimulus.
Positive_regulation (facing) of ecto-ATPases in external
11) Confidence 0.17 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096533 Disease Relevance 0 Pain Relevance 0.08
Simultaneously, serum osteocalcin increased.
Positive_regulation (increased) of osteocalcin
12) Confidence 0.14 Published 1990 Journal Ther Umsch Section Abstract Doc Link 2128966 Disease Relevance 0.87 Pain Relevance 0.46
Plasma osteocalcin was subnormal at diagnosis in 29/40 (73%) but increased to normal by 6 months of treatment.
Positive_regulation (increased) of osteocalcin in Plasma
13) Confidence 0.14 Published 1996 Journal J. Bone Miner. Res. Section Abstract Doc Link 8915786 Disease Relevance 0.34 Pain Relevance 0.08
Mean serum osteocalcin concentration was unchanged during the 1st year of SCT treatment but was significantly elevated during the 2nd year (P < 0.01).
Positive_regulation (elevated) of osteocalcin
14) Confidence 0.11 Published 1997 Journal Maturitas Section Body Doc Link 9522322 Disease Relevance 0 Pain Relevance 0
Osteocalcin levels were only elevated in AS.
Positive_regulation (elevated) of Osteocalcin
15) Confidence 0.05 Published 2002 Journal J. Rheumatol. Section Body Doc Link 12136902 Disease Relevance 0 Pain Relevance 0
In adult onset SAPHO syndrome, increased levels of serum osteocalcin have been observed in some patients, suggesting greater importance of bone resorption compared with bone formation in this disorder [21].
Positive_regulation (increased) of osteocalcin associated with syndrome and hypercalcemia
16) Confidence 0.04 Published 2009 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2631594 Disease Relevance 1.60 Pain Relevance 0.44
Previous studies have shown that OVX in cynomolgus monkeys increased urinary levels of deoxypyridinoline and serum levels of osteocalcin, ALP, bone-specific ALP, and tartrate-resistant acid phosphatase.5,9,14-16 However, recent studies demonstrated OVX-induced elevations in urinary levels of CTX in addition to the above markers in cynomolgus monkeys.17,18 Serum and urinary levels of bone turnover markers were shown to increase within a few months, peak at 6-12 months, and remain elevated for 18 months or longer.8 All of these results indicate that OVX rapidly increases the serum and urinary levels of bone turnover markers and maintains this state for a couple of years in cynomolgus monkeys, consistent with our results (Fig. 3).
Positive_regulation (increased) of osteocalcin
17) Confidence 0.02 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2703758 Disease Relevance 0.50 Pain Relevance 0
Serum levels of BALP and osteocalcin were significantly increased after 12 weeks of treatment (p < 0.05).
Positive_regulation (increased) of osteocalcin
18) Confidence 0.01 Published 2007 Journal J. Rheumatol. Section Body Doc Link 17610317 Disease Relevance 0.06 Pain Relevance 0

General Comments

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