INT90890

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Context Info
Confidence 0.67
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 25
Total Number 25
Disease Relevance 9.32
Pain Relevance 4.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RARA) signal transduction (RARA) nucleus (RARA)
enzyme binding (RARA) transcription factor binding (RARA) cytoplasm (RARA)
Anatomy Link Frequency
spinal cord 1
proximal 1
band 1
lungs 1
RARA (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 248 99.96 Very High Very High Very High
c fibre 51 99.80 Very High Very High Very High
Spinal cord 39 99.60 Very High Very High Very High
cytokine 26 96.68 Very High Very High Very High
substance P 6 96.32 Very High Very High Very High
antagonist 61 95.68 Very High Very High Very High
qutenza 24 95.24 Very High Very High Very High
Action potential 108 90.88 High High
Potency 24 88.08 High High
Opioid 9 84.80 Quite High
Disease Link Frequency Relevance Heat
Leukemia 28 100.00 Very High Very High Very High
Rheumatoid Arthritis 171 99.98 Very High Very High Very High
Cancer 187 99.80 Very High Very High Very High
Toxicity 19 97.94 Very High Very High Very High
Lung Cancer 6 97.92 Very High Very High Very High
Breast Cancer 51 97.28 Very High Very High Very High
Neuroblastoma 44 97.00 Very High Very High Very High
Myelodysplastic Syndromes 6 95.68 Very High Very High Very High
Infection 8 93.84 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 8 93.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A multicenter phase II study was initiated to investigate the efficacy, toxicity and tolerability of an oral regimen of 9-cis retinoic acid (9CRA) as a differentiation-inducing agent stimulating both retinoic acid receptor (RAR) and retinoic X receptor (RXR).
Positive_regulation (stimulating) of RAR associated with toxicity
1) Confidence 0.67 Published 2000 Journal Leukemia Section Abstract Doc Link 10995004 Disease Relevance 0.93 Pain Relevance 0
Retinoic acid receptor (RAR)-alpha was not affected by treatment and RAR-alpha was moderately influenced whereas RAR-beta (concomitantly with transforming growth factor-beta) was induced in 33% of patients by ATRA alone.
Positive_regulation (induced) of RAR
2) Confidence 0.67 Published 2000 Journal Int. J. Oncol. Section Abstract Doc Link 11029503 Disease Relevance 0.36 Pain Relevance 0
In some cases, exposure to topoisomerase II poisons has been associated with the formation of specific types of leukemia that involve the MLL (mixed lineage leukemia) gene at chromosome band 11q23 or the chromosome 15;17 translocation that joins the PML (promyelocytic leukemia) and RARA (retinoic acid receptor ?)
Positive_regulation (joins) of RARA in band associated with leukemia
3) Confidence 0.44 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2647315 Disease Relevance 0.46 Pain Relevance 0
At the concentration used, the three selective RAR agonists (BMS-753 for RAR-?
Positive_regulation (selective) of RAR associated with agonist
4) Confidence 0.44 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0 Pain Relevance 0.52
For experiments of RAR subtype silencing, double-stranded small interfering RNA (siRNA) corresponding to a region of RAR-?
Positive_regulation (experiments) of RAR
5) Confidence 0.44 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0.08 Pain Relevance 0.03
anti-tumor activity required a functional RAR?
Positive_regulation (required) of RAR associated with cancer
6) Confidence 0.40 Published 2007 Journal Nutr J Section Body Doc Link PMC2018695 Disease Relevance 0.88 Pain Relevance 0.03
For instance, functional regeneration of sensory axons into the spinal cord was achieved after stimulation of the retinoic acid receptor by such compounds (Wong et al., 2006).
Positive_regulation (stimulation) of retinoic acid receptor in spinal cord associated with spinal cord
7) Confidence 0.40 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009445 Disease Relevance 0.50 Pain Relevance 0.37
The increase in RAR-?
Positive_regulation (increase) of RAR
8) Confidence 0.33 Published 2007 Journal J Neuroinflammation Section Abstract Doc Link PMC1769480 Disease Relevance 0.23 Pain Relevance 0.12
activity and inducing RAR?
Positive_regulation (inducing) of RAR
9) Confidence 0.33 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 1.22 Pain Relevance 0.04
This particular arrangement permits RAR and VDR upon ligand binding to undergo conformational changes that facilitate the recruitment of coactivator complexes.
Positive_regulation (permits) of RAR
10) Confidence 0.29 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0
1) upregulates RAR?
Positive_regulation (upregulates) of RAR
11) Confidence 0.27 Published 2010 Journal Breast Cancer Res Section Body Doc Link PMC2949655 Disease Relevance 0.85 Pain Relevance 0
The transcriptional activity of PPAR depends on the presence of the retinoic X receptor (RXR), activated by 9-cis retinoic acid (9-cis RA).
Positive_regulation (activated) of retinoic X receptor associated with rheumatoid arthritis
12) Confidence 0.27 Published 2007 Journal Nutr J Section Body Doc Link PMC2018695 Disease Relevance 0.90 Pain Relevance 0.14
In addition, RA stimulated the activity of the RAR?
Positive_regulation (stimulated) of RAR associated with rheumatoid arthritis
13) Confidence 0.27 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.63 Pain Relevance 0
processes are critical for the transcriptional activity of RAR/RXR
Positive_regulation (critical) of RAR
14) Confidence 0.25 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.13 Pain Relevance 0
Binding of DREAM to the proximal RAR?
Positive_regulation (proximal) of RAR in proximal
15) Confidence 0.25 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.31 Pain Relevance 0
This allows ligand-dependent activation for RXR-RAR heterodimer on DR5, but not on DR1.
Positive_regulation (activation) of RAR
16) Confidence 0.14 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0 Pain Relevance 0
In rabbits, the increase in RAR activity was associated with microvascular leakage in the lungs, and in the guinea pig the substance P-induced discharge in RAR activity was inhibited by nitric oxide synthase inhibitors.


Positive_regulation (increase) of RAR in lungs associated with substance p
17) Confidence 0.12 Published 2001 Journal Respir Res Section Body Doc Link PMC59581 Disease Relevance 0.59 Pain Relevance 0.63
These effects are induced by ligand-mediated activation of the retinoid receptors--retinoic acid receptor (RAR) and retinoid X receptor (RXR).
Positive_regulation (activation) of RAR
18) Confidence 0.11 Published 2004 Journal J. Neuroimmunol. Section Abstract Doc Link 14741437 Disease Relevance 0.28 Pain Relevance 0.59
These effects are induced by ligand-mediated activation of the retinoid receptors--retinoic acid receptor (RAR) and retinoid X receptor (RXR).
Positive_regulation (activation) of retinoic acid receptor
19) Confidence 0.10 Published 2004 Journal J. Neuroimmunol. Section Abstract Doc Link 14741437 Disease Relevance 0.28 Pain Relevance 0.59
Inhalation of leukotriene C4 causes activation of RAR fibers in guinea pig airways, but this may be secondary to bronchoconstriction [12].
Positive_regulation (activation) of RAR
20) Confidence 0.08 Published 2001 Journal Respir Res Section Body Doc Link PMC59581 Disease Relevance 0.33 Pain Relevance 0.50

General Comments

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