INT90897

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Context Info
Confidence 0.45
First Reported 2000
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.28
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Rab27a) Golgi apparatus (Rab27a) intracellular (Rab27a)
GTPase activity (Rab27a) pigmentation (Rab27a) vesicle-mediated transport (Rab27a)
Anatomy Link Frequency
melanocytes 1
mast cells 1
lymphoblasts 1
Rab27a (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 8 100.00 Very High Very High Very High
imagery 8 71.04 Quite High
Serotonin 12 62.48 Quite High
antinociception 2 50.00 Quite Low
Analgesic 1 10.00 Low Low
anesthesia 8 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Immobilon 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Choroideremia 45 99.84 Very High Very High Very High
Disease 16 99.84 Very High Very High Very High
Anaphylaxis 20 99.32 Very High Very High Very High
Targeted Disruption 374 99.04 Very High Very High Very High
Retina Disease 12 97.16 Very High Very High Very High
Syndrome 31 92.72 High High
Stress 2 81.84 Quite High
Piebaldism 8 60.72 Quite High
Injury 2 47.72 Quite Low
Necrosis 2 31.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While this work was in progress, there was a considerable advance in understanding the function of Rab27a and its role in disease.
Regulation (role) of Rab27a associated with disease
1) Confidence 0.45 Published 2002 Journal BMC Cell Biol Section Body Doc Link PMC137576 Disease Relevance 0.69 Pain Relevance 0
Fourthly, we observed that these same Rab27a mutations were effective in cell culture models [34].
Regulation (effective) of Rab27a
2) Confidence 0.45 Published 2002 Journal BMC Cell Biol Section Body Doc Link PMC137576 Disease Relevance 0.55 Pain Relevance 0
The mode of action of Rab27a in melanocytes as a key regulator of melanosome motility to recruit myosin motors to mature melanosomes and thus induce their peripheral retention has been intensively investigated (17,18).
Regulation (regulator) of Rab27a in melanocytes
3) Confidence 0.45 Published 2007 Journal Traffic (Copenhagen, Denmark) Section Body Doc Link PMC2063611 Disease Relevance 0.40 Pain Relevance 0.04
These results were consistent with the PCA assay in vivo and suggested that Rab27 proteins are key regulators of antigen-induced secretion in mast cells.
Regulation (regulators) of Rab27 in mast cells associated with anaphylaxis
4) Confidence 0.45 Published 2007 Journal Traffic (Copenhagen, Denmark) Section Body Doc Link PMC2063611 Disease Relevance 0.59 Pain Relevance 0.03
Effects of hepatotoxic doses of acetaminophen and furosemide on tissue concentrations of CoASH and CoASSG in vivo.
Regulation (Effects) of CoASH associated with paracetamol
5) Confidence 0.30 Published 2000 Journal Chem. Res. Toxicol. Section Title Doc Link 10995260 Disease Relevance 0.08 Pain Relevance 0.43
Pre-treatment with L-arginine was found to significantly reverse the three respective doses of ASH antinociception; pre-treatment with D-arginine did not produce any significant change in the ASH activity; pre-treatment with L-NAME only significantly increased the 0.170 and 0.426 mg/kg ASH antinociception; and pre-treatment with MB significantly enhanced the respective doses of ASH antinociception, respectively.
Regulation (change) of ASH
6) Confidence 0.27 Published 2005 Journal J Pharm Pharm Sci Section Body Doc Link 16124931 Disease Relevance 0 Pain Relevance 0
We have previously reported that Rab27a is the Rab most affected in CHM lymphoblasts and hypothesised that the selective dysfunction of Rab27a (and possibly a few other Rab GTPases) plays an essential role in the retinal degenerative process.


Regulation (affected) of Rab27a in lymphoblasts associated with choroideremia
7) Confidence 0.27 Published 2002 Journal BMC Cell Biol Section Abstract Doc Link PMC137576 Disease Relevance 0.97 Pain Relevance 0

General Comments

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