INT90897
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
While this work was in progress, there was a considerable advance in understanding the function of Rab27a and its role in disease. | |||||||||||||||
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Fourthly, we observed that these same Rab27a mutations were effective in cell culture models [34]. | |||||||||||||||
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The mode of action of Rab27a in melanocytes as a key regulator of melanosome motility to recruit myosin motors to mature melanosomes and thus induce their peripheral retention has been intensively investigated (17,18). | |||||||||||||||
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These results were consistent with the PCA assay in vivo and suggested that Rab27 proteins are key regulators of antigen-induced secretion in mast cells. | |||||||||||||||
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Effects of hepatotoxic doses of acetaminophen and furosemide on tissue concentrations of CoASH and CoASSG in vivo. | |||||||||||||||
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Pre-treatment with L-arginine was found to significantly reverse the three respective doses of ASH antinociception; pre-treatment with D-arginine did not produce any significant change in the ASH activity; pre-treatment with L-NAME only significantly increased the 0.170 and 0.426 mg/kg ASH antinociception; and pre-treatment with MB significantly enhanced the respective doses of ASH antinociception, respectively. | |||||||||||||||
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We have previously reported that Rab27a is the Rab most affected in CHM lymphoblasts and hypothesised that the selective dysfunction of Rab27a (and possibly a few other Rab GTPases) plays an essential role in the retinal degenerative process.
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General Comments
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