INT90897

Context Info Confidence 0.45 First Reported 2000 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 7 Disease Relevance 3.28 Pain Relevance 0.50

endosome (Rab27a) Golgi apparatus (Rab27a) intracellular (Rab27a) GTPase activity (Rab27a) pigmentation (Rab27a) vesicle-mediated transport (Rab27a)

Anatomy Link Frequency melanocytes 1 mast cells 1 lymphoblasts 1 Rab27a (Mus musculus)

Pain Link Frequency Relevance Heat Paracetamol 8 100.00 imagery 8 71.04 Serotonin 12 62.48 antinociception 2 50.00 Analgesic 1 10.00 anesthesia 8 5.00 Inflammatory mediators 4 5.00 ketamine 3 5.00 Immobilon 3 5.00 cytokine 2 5.00

Disease Link Frequency Relevance Heat Choroideremia 45 99.84 Disease 16 99.84 Anaphylaxis 20 99.32 Targeted Disruption 374 99.04 Retina Disease 12 97.16 Syndrome 31 92.72 Stress 2 81.84 Piebaldism 8 60.72 Injury 2 47.72 Necrosis 2 31.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

While this work was in progress, there was a considerable advance in understanding the function of Rab27a and its role in disease.

Regulation (role) of Rab27a associated with disease

1) Confidence 0.45 Published 2002 Journal BMC Cell Biol Section Body Doc Link PMC137576 Disease Relevance 0.69 Pain Relevance 0

Fourthly, we observed that these same Rab27a mutations were effective in cell culture models [34].

Regulation (effective) of Rab27a

2) Confidence 0.45 Published 2002 Journal BMC Cell Biol Section Body Doc Link PMC137576 Disease Relevance 0.55 Pain Relevance 0

The mode of action of Rab27a in melanocytes as a key regulator of melanosome motility to recruit myosin motors to mature melanosomes and thus induce their peripheral retention has been intensively investigated (17,18).

Regulation (regulator) of Rab27a in melanocytes

3) Confidence 0.45 Published 2007 Journal Traffic (Copenhagen, Denmark) Section Body Doc Link PMC2063611 Disease Relevance 0.40 Pain Relevance 0.04

These results were consistent with the PCA assay in vivo and suggested that Rab27 proteins are key regulators of antigen-induced secretion in mast cells.

Regulation (regulators) of Rab27 in mast cells associated with anaphylaxis

4) Confidence 0.45 Published 2007 Journal Traffic (Copenhagen, Denmark) Section Body Doc Link PMC2063611 Disease Relevance 0.59 Pain Relevance 0.03

Effects of hepatotoxic doses of acetaminophen and furosemide on tissue concentrations of CoASH and CoASSG in vivo.

Regulation (Effects) of CoASH associated with paracetamol

5) Confidence 0.30 Published 2000 Journal Chem. Res. Toxicol. Section Title Doc Link 10995260 Disease Relevance 0.08 Pain Relevance 0.43

Pre-treatment with L-arginine was found to significantly reverse the three respective doses of ASH antinociception; pre-treatment with D-arginine did not produce any significant change in the ASH activity; pre-treatment with L-NAME only significantly increased the 0.170 and 0.426 mg/kg ASH antinociception; and pre-treatment with MB significantly enhanced the respective doses of ASH antinociception, respectively.

Regulation (change) of ASH

6) Confidence 0.27 Published 2005 Journal J Pharm Pharm Sci Section Body Doc Link 16124931 Disease Relevance 0 Pain Relevance 0

We have previously reported that Rab27a is the Rab most affected in CHM lymphoblasts and hypothesised that the selective dysfunction of Rab27a (and possibly a few other Rab GTPases) plays an essential role in the retinal degenerative process.

Regulation (affected) of Rab27a in lymphoblasts associated with choroideremia

7) Confidence 0.27 Published 2002 Journal BMC Cell Biol Section Abstract Doc Link PMC137576 Disease Relevance 0.97 Pain Relevance 0

General Comments

This test has worked.