INT90898

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Context Info
Confidence 0.43
First Reported 2000
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 1.99
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Rab27a) Golgi apparatus (Rab27a) intracellular (Rab27a)
GTPase activity (Rab27a) pigmentation (Rab27a) vesicle-mediated transport (Rab27a)
Rab27a (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 16 99.04 Very High Very High Very High
antinociception 4 50.00 Quite Low
Analgesic 2 10.00 Low Low
anesthesia 6 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Immobilon 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 276 98.40 Very High Very High Very High
Injury 4 96.96 Very High Very High Very High
Choroideremia 45 92.08 High High
Disease 12 76.88 Quite High
Stress 4 75.56 Quite High
Retina Disease 12 72.24 Quite High
Ganglion Cysts 3 71.92 Quite High
Necrosis 4 60.72 Quite High
Syndrome 27 5.00 Very Low Very Low Very Low
Piebaldism 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The presence of NO was found to reverse ASH antinociceptive activity while blocking of cGMP system enhanced it.


Negative_regulation (reverse) of ASH
1) Confidence 0.43 Published 2005 Journal J Pharm Pharm Sci Section Body Doc Link 16124931 Disease Relevance 0 Pain Relevance 0
The rationale for the present study was to generate transgenic mice expressing dominant-negative mutant Rab27 proteins in order to interfere with the function of the wild type alleles and disrupt the Rab27 regulatory function.
Negative_regulation (disrupt) of Rab27 associated with targeted disruption
2) Confidence 0.43 Published 2002 Journal BMC Cell Biol Section Body Doc Link PMC137576 Disease Relevance 0.58 Pain Relevance 0
Therefore, the transgene expression level was determined in each line by quantitating the Rab27 (endogenous plus mutant mRNA) relative to Hprt cDNA using all four primers, 0.025 ?
Negative_regulation (quantitating) of Rab27
3) Confidence 0.43 Published 2002 Journal BMC Cell Biol Section Body Doc Link PMC137576 Disease Relevance 0.40 Pain Relevance 0
Decreases in CoASH levels were not observed in mice given comparably hepatotoxic doses of furosemide, which diminishes the concern that the decreases in CoASH levels observed in the acetaminophen-treated mice were simply secondary to injury.
Negative_regulation (decreases) of CoASH associated with paracetamol and injury
4) Confidence 0.39 Published 2000 Journal Chem. Res. Toxicol. Section Abstract Doc Link 10995260 Disease Relevance 0.28 Pain Relevance 0.52
Decreases in CoASH levels were not observed in mice given comparably hepatotoxic doses of furosemide, which diminishes the concern that the decreases in CoASH levels observed in the acetaminophen-treated mice were simply secondary to injury.
Negative_regulation (Decreases) of CoASH associated with paracetamol and injury
5) Confidence 0.39 Published 2000 Journal Chem. Res. Toxicol. Section Abstract Doc Link 10995260 Disease Relevance 0.17 Pain Relevance 0.52
In addition, MB significantly reversed the L-arginine nociception on 0.426 mg/kg ASH.
Negative_regulation (reversed) of ASH
6) Confidence 0.38 Published 2005 Journal J Pharm Pharm Sci Section Body Doc Link 16124931 Disease Relevance 0 Pain Relevance 0
Interestingly, this transgenic line showed the highest level of dominant-negative transgenic protein and thus the low-normal ERG may have resulted from a dominant-negative effect of mutant Rab27a.
Negative_regulation (effect) of Rab27a associated with targeted disruption
7) Confidence 0.38 Published 2002 Journal BMC Cell Biol Section Body Doc Link PMC137576 Disease Relevance 0.56 Pain Relevance 0

General Comments

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