INT90899

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Context Info
Confidence 0.78
First Reported 2000
Last Reported 2008
Negated 3
Speculated 1
Reported most in Body
Documents 49
Total Number 51
Disease Relevance 26.71
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Rab27a) Golgi apparatus (Rab27a) intracellular (Rab27a)
GTPase activity (Rab27a) pigmentation (Rab27a) vesicle-mediated transport (Rab27a)
Anatomy Link Frequency
Mast cells 3
plasma 1
hepatocytes 1
liver 1
bone marrow 1
Rab27a (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 16 99.42 Very High Very High Very High
Serotonin 66 83.52 Quite High
Inflammation 6 75.88 Quite High
fibrosis 16 74.24 Quite High
imagery 44 64.88 Quite High
Inflammatory mediators 22 46.92 Quite Low
cytokine 11 32.76 Quite Low
anesthesia 85 5.00 Very Low Very Low Very Low
ketamine 37 5.00 Very Low Very Low Very Low
Immobilon 37 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 3971 100.00 Very High Very High Very High
Nash(non-alcoholic Steatohepatitis) 14 99.80 Very High Very High Very High
Hypersensitivity 66 99.32 Very High Very High Very High
Choroideremia 555 99.06 Very High Very High Very High
Immunodeficiency 48 98.00 Very High Very High Very High
Hepatitis Virus Infection 4 97.84 Very High Very High Very High
Disease 204 97.60 Very High Very High Very High
Stress 38 97.12 Very High Very High Very High
Piebaldism 85 93.76 High High
Anaphylaxis 110 93.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In tissues where endogenous Rab27a expression was high, the levels of Rab27aT23N transgenic protein were nearly equal to or lower than, but never higher, than endogenous protein (Fig. 4B).
Gene_expression (expression) of Rab27a associated with targeted disruption
1) Confidence 0.78 Published 2002 Journal BMC Cell Biol Section Body Doc Link PMC137576 Disease Relevance 0.59 Pain Relevance 0
We have not been able to detect differences in the levels of Rab27a in any of the twelve tissues described above (data not shown).


Gene_expression (levels) of Rab27a
2) Confidence 0.78 Published 2002 Journal BMC Cell Biol Section Body Doc Link PMC137576 Disease Relevance 0.55 Pain Relevance 0
-globin constructs expressing either Rab27aWT, Rab27aQ78L, Rab27aT23N or Rab27aN133I, then metabolically labelled with [35S]methionine/cysteine for 1 h, followed by different time intervals of chase in the presence of non-radiolabelled medium.
Gene_expression (expressing) of Rab27aWT
3) Confidence 0.78 Published 2002 Journal BMC Cell Biol Section Body Doc Link PMC137576 Disease Relevance 0.44 Pain Relevance 0
-globin constructs expressing either Rab27aWT, Rab27aQ78L, Rab27aT23N or Rab27aN133I, then metabolically labelled with [35S]methionine/cysteine for 1 h, followed by different time intervals of chase in the presence of non-radiolabelled medium.
Gene_expression (expressing) of Rab27aN133I
4) Confidence 0.78 Published 2002 Journal BMC Cell Biol Section Body Doc Link PMC137576 Disease Relevance 0.44 Pain Relevance 0
The lack of phenoytpe in the transgenic mice expressing dominant-negative mutant Rab27a and Rab27b could have been due to non-functional mutant proteins.
Gene_expression (expressing) of Rab27a associated with targeted disruption
5) Confidence 0.78 Published 2002 Journal BMC Cell Biol Section Body Doc Link PMC137576 Disease Relevance 0.59 Pain Relevance 0
-globin constructs expressing either Rab27aWT, Rab27aQ78L, Rab27aT23N or Rab27aN133I, then metabolically labelled with [35S]methionine/cysteine for 1 h, followed by different time intervals of chase in the presence of non-radiolabelled medium.
Gene_expression (expressing) of Rab27aT23N
6) Confidence 0.78 Published 2002 Journal BMC Cell Biol Section Body Doc Link PMC137576 Disease Relevance 0.44 Pain Relevance 0
The results above suggested that both Rab27a and Rab27b expression was required for normal mast cell function, presumably in the control of regulated secretion.
Gene_expression (expression) of Rab27a in mast cell
7) Confidence 0.78 Published 2007 Journal Traffic (Copenhagen, Denmark) Section Body Doc Link PMC2063611 Disease Relevance 0.80 Pain Relevance 0.03
Rab27a is widely expressed (24), whereas the expression of Rab27b is more restricted and detectable in platelets, the pituitary gland and the digestive tract (31–33).
Gene_expression (expressed) of Rab27a in pituitary gland
8) Confidence 0.78 Published 2007 Journal Traffic (Copenhagen, Denmark) Section Body Doc Link PMC2063611 Disease Relevance 0.40 Pain Relevance 0
Mast cells represent a cell type where both Rab27a and Rab27b are expressed, providing an opportunity to determine the relative contributions of each isoform and address redundancy issues.
Gene_expression (expressed) of Rab27a in Mast cells
9) Confidence 0.78 Published 2007 Journal Traffic (Copenhagen, Denmark) Section Body Doc Link PMC2063611 Disease Relevance 0.41 Pain Relevance 0.03
Both Rab27a and Rab27b isoforms are expressed in bone marrow-derived mast cells (BMMC) and localize to secretory granules.
Gene_expression (expressed) of Rab27a in mast cells
10) Confidence 0.78 Published 2007 Journal Traffic (Copenhagen, Denmark) Section Abstract Doc Link PMC2063611 Disease Relevance 0.41 Pain Relevance 0.03
Figure 1B provides a schematic diagram of the PCAG/myc-Rab27/?
Gene_expression (/) of Rab27
11) Confidence 0.67 Published 2002 Journal BMC Cell Biol Section Body Doc Link PMC137576 Disease Relevance 0.50 Pain Relevance 0
The pCAG/myc-Rab27/?
Gene_expression (The) of Rab27
12) Confidence 0.67 Published 2002 Journal BMC Cell Biol Section Body Doc Link PMC137576 Disease Relevance 0.63 Pain Relevance 0
Under these conditions, we observed that both myc-tagged wild type Rab27a and Rab27aQ78L decayed with a half-life of approximately 24 h (Fig. 5A,5C,5E).
Gene_expression (decayed) of Rab27aQ78L
13) Confidence 0.67 Published 2002 Journal BMC Cell Biol Section Body Doc Link PMC137576 Disease Relevance 0.26 Pain Relevance 0
Membranes were prehybridised and hybridised with Rab27a or Rab27b probe, corresponding to the entire Rab27 coding sequence, radiolabelled with 20 ?
Gene_expression (probe) of Rab27a
14) Confidence 0.67 Published 2002 Journal BMC Cell Biol Section Body Doc Link PMC137576 Disease Relevance 0.37 Pain Relevance 0
To quantify approximately the level of expression, the Rab27a or Rab27b product was compared to Hprt product (Fig. 3C and Table 3).
Gene_expression (product) of Rab27a
15) Confidence 0.67 Published 2002 Journal BMC Cell Biol Section Body Doc Link PMC137576 Disease Relevance 0.68 Pain Relevance 0
A 3.4 kb XhoI – NotI fragment containing the Ptyr/Rab27a/hGH or a 3.4 kb SpeI – BamHI fragment containing PCAG/myc-Rab27/?
Gene_expression (containing) of Rab27a
16) Confidence 0.67 Published 2002 Journal BMC Cell Biol Section Body Doc Link PMC137576 Disease Relevance 0.16 Pain Relevance 0
Under these conditions, we observed that both myc-tagged wild type Rab27a and Rab27aQ78L decayed with a half-life of approximately 24 h (Fig. 5A,5C,5E).
Gene_expression (decayed) of Rab27a
17) Confidence 0.67 Published 2002 Journal BMC Cell Biol Section Body Doc Link PMC137576 Disease Relevance 0.26 Pain Relevance 0
Transgenic mice (Rab27T23N, Rab27aQ78L and Rab27aWT) were crossed with ashen (ash/ash) on a C57BL/6J background obtained by repeated backcrossing of ash/+ mice (over five generations) with wild-type C57BL/6J mice [28].
Gene_expression (crossed) of Rab27aWT associated with targeted disruption
18) Confidence 0.67 Published 2002 Journal BMC Cell Biol Section Body Doc Link PMC137576 Disease Relevance 0.38 Pain Relevance 0
Transgenic lines generated following injection of the PTyr/Rab27a/hGH or PCAG/myc-Rab27/?
Gene_expression (injection) of Rab27a associated with targeted disruption
19) Confidence 0.67 Published 2002 Journal BMC Cell Biol Section Body Doc Link PMC137576 Disease Relevance 0.49 Pain Relevance 0
Figure 1A provides a schematic diagram of the PTyr/Rab27a/hGH expression constructs.
Gene_expression (expression) of Rab27a
20) Confidence 0.67 Published 2002 Journal BMC Cell Biol Section Body Doc Link PMC137576 Disease Relevance 0.45 Pain Relevance 0

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