INT90900

Context Info Confidence 0.06 First Reported 2000 Last Reported 2000 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.09 Pain Relevance 0.34

pigmentation (Hps3) cytoplasm (Hps3)

Hps3 (Mus musculus)

Pain Link Frequency Relevance Heat Paracetamol 8 100.00

Disease Link Frequency Relevance Heat Stress 2 85.92 Injury 2 25.00 Necrosis 2 25.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The effects of hepatotoxic doses of acetaminophen on tissue concentrations of CoA in the thiol form (CoASH) and as the corresponding mixed disulfide with GSH (CoASSG) were determined to test the hypotheses that early oxidant effects of acetaminophen are expressed principally in the mitochondrial compartment and that oxidative shifts in this redox couple could be employed as biomarkers of mitochondrially compartmentalized oxidant stresses.

Regulation (effects) of CoA associated with stress and paracetamol

1) Confidence 0.06 Published 2000 Journal Chem. Res. Toxicol. Section Abstract Doc Link 10995260 Disease Relevance 0.09 Pain Relevance 0.34

General Comments

This test has worked.