INT90903

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.47
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 3.49
Pain Relevance 11.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprk1) plasma membrane (Oprk1) signal transducer activity (Oprk1)
Anatomy Link Frequency
brainstem 2
respiratory 2
Oprk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 149 100.00 Very High Very High Very High
opioid receptor 128 100.00 Very High Very High Very High
Dynorphin 116 100.00 Very High Very High Very High
agonist 66 100.00 Very High Very High Very High
medulla 7 100.00 Very High Very High Very High
depression 14 99.98 Very High Very High Very High
Morphine 32 99.48 Very High Very High Very High
Analgesic 22 99.44 Very High Very High Very High
Opioid 139 99.16 Very High Very High Very High
Delta opioid receptors 1 99.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 122 99.98 Very High Very High Very High
Respiratory Failure 7 99.98 Very High Very High Very High
Targeted Disruption 41 99.64 Very High Very High Very High
Sleep Disorders 5 99.60 Very High Very High Very High
Cognitive Disorder 10 96.88 Very High Very High Very High
Depression 7 91.04 High High
Anxiety Disorder 92 75.00 Quite High
Myocardial Infarction 1 75.00 Quite High
Pain 41 74.56 Quite High
Cv Unclassified Under Development 3 61.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: Neonatal stress increases KOR activation via the dynorphin system.
Positive_regulation (increases) of Positive_regulation (activation) of KOR
1) Confidence 0.47 Published 2009 Journal Neonatology Section Body Doc Link 19478529 Disease Relevance 0 Pain Relevance 0
Overall, these results suggest that stress-induced activation of the KOR may be both necessary and sufficient to produce subsequent deficits in novel object recognition.
Positive_regulation (induced) of Positive_regulation (activation) of KOR associated with stress, cognitive disorder, eae and kappa opioid receptor
2) Confidence 0.42 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19339623 Disease Relevance 1.08 Pain Relevance 0.75
Data regarding the effects of U-69593 and nor-binaltorphimine in KO suggest that the kappa opioid receptor is up-regulated as a consequence of prodynorphin gene deletion and that this adaptation underlies the decrease in basal DA dynamics and cocaine-evoked DA levels observed in DYN KO mice.
Positive_regulation (consequence) of Positive_regulation (up-regulated) of kappa opioid receptor associated with targeted disruption, dopamine, dynorphin, kappa opioid receptor and cocaine
3) Confidence 0.37 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16420432 Disease Relevance 0.72 Pain Relevance 1.55
Using pharmacological and genetic approaches, we found that the anxiogenic-like effects of Corticotropin Releasing Factor (CRF) were triggered by CRF1-R activation of the dynorphin/kappa opioid receptor (KOR) system.
Positive_regulation (triggered) of Positive_regulation (activation) of KOR associated with dynorphin and kappa opioid receptor
4) Confidence 0.36 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2795205 Disease Relevance 0.39 Pain Relevance 0.72
These results indicate that stimulation of KOR caused by repeated morphine treatment either inhibits MOR desensitization or accelerates recycling of MOR on the cell surface, thereby suppressing morphine tolerance.
Positive_regulation (caused) of Positive_regulation (stimulation) of KOR associated with tolerance, mu opioid receptor, kappa opioid receptor and morphine
5) Confidence 0.33 Published 2008 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 18718122 Disease Relevance 0.07 Pain Relevance 2.28
Using pharmacological and genetic approaches, we found that the anxiogenic-like effects of Corticotropin Releasing Factor (CRF) were triggered by CRF1-R activation of the dynorphin/kappa opioid receptor (KOR) system.
Positive_regulation (triggered) of Positive_regulation (activation) of kappa opioid receptor associated with dynorphin and kappa opioid receptor
6) Confidence 0.31 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2795205 Disease Relevance 0.39 Pain Relevance 0.72
Taken together, these results suggest that repeated stimulation of kappa-opioid receptor markedly increases the functional mu- and delta-opioid receptors, whereas repeated stimulation of either mu- or delta-opioid receptor had no direct effect on kappa-opioidergic function in mice.
Positive_regulation (increases) of Positive_regulation (stimulation) of kappa-opioid receptor associated with kappa opioid receptor, opioid receptor and delta opioid receptors
7) Confidence 0.31 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 14975677 Disease Relevance 0 Pain Relevance 1.14
KOR activation by the agonist produced a strong increase in potassium current through coexpressed G protein-gated inwardly rectifying potassium channels (K(IR)3).
Positive_regulation (increase) of Positive_regulation (activation) of KOR associated with agonist, kappa opioid receptor and potassium channel
8) Confidence 0.22 Published 2000 Journal J. Biol. Chem. Section Abstract Doc Link 10995763 Disease Relevance 0 Pain Relevance 0.63
These results show that MOR and DOR activation causes respiratory depression as a result of decreased breathing frequency, whereas Vt is increased after KOR activation.
Positive_regulation (increased) of Positive_regulation (activation) of KOR in respiratory associated with depression, respiratory failure and kappa opioid receptor
9) Confidence 0.21 Published 2008 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 18784338 Disease Relevance 0.19 Pain Relevance 0.74
KOR agonists also reduced arrhythmogenesis; however, these responses appear to be independent of KOR activation.
Neg (independent) Positive_regulation (independent) of Positive_regulation (activation) of KOR associated with agonist and kappa opioid receptor
10) Confidence 0.09 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15076225 Disease Relevance 0.19 Pain Relevance 0.81
Of particular relevance to the use of opioids as analgesics are respiratory depression mediated though activation of MOR and DOR in the brainstem, as well as KOR-mediated sedation; both of which can be dose-limiting side effects of systemic treatment with opioids (Sessle and Henry 1985; Mansour et al 1988).


Positive_regulation (mediated) of Positive_regulation (activation) of KOR in brainstem associated with medulla, depression, analgesic, respiratory failure, sleep disorders and opioid
11) Confidence 0.06 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 0.46 Pain Relevance 1.47
Without LMB, a significant redistribution of Grb7 (Fig. 4 A, bottom left) and KOR mRNA (Fig. 4 A, right) occurred after 90 and 120 min of EGF treatment, which is consistent with the time point at which nuclear Grb7 is dephosphorylated.
Positive_regulation (after) of Positive_regulation (occurred) of KOR
12) Confidence 0.02 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0 Pain Relevance 0
The activation of mu-, delta- and kappa1-opioid receptors by their respective agonists increases the binding of the non-hydrolyzable GTP analog guanosine-5'-(gamma-thio)-triphosphate (GTPgammaS) to G proteins.
Positive_regulation (increases) of Positive_regulation (activation) of kappa1-opioid associated with agonist and opioid receptor
13) Confidence 0.02 Published 2000 Journal Life Sci. Section Abstract Doc Link 11105989 Disease Relevance 0 Pain Relevance 0.37

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox