INT90909

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Context Info
Confidence 0.55
First Reported 2000
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 44
Total Number 44
Disease Relevance 23.83
Pain Relevance 12.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOS1) oxidoreductase activity (NOS1) cytoskeleton (NOS1)
cytoplasm (NOS1)
Anatomy Link Frequency
macrophages 6
smooth muscle 5
brain 4
blood 4
neurons 4
NOS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 438 100.00 Very High Very High Very High
cytokine 167 100.00 Very High Very High Very High
antagonist 93 100.00 Very High Very High Very High
substance P 79 100.00 Very High Very High Very High
tolerance 46 100.00 Very High Very High Very High
Morphine 22 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 18 100.00 Very High Very High Very High
depression 17 100.00 Very High Very High Very High
Antinociceptive 13 100.00 Very High Very High Very High
agonist 148 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 486 100.00 Very High Very High Very High
Depression 17 100.00 Very High Very High Very High
Stress 153 99.84 Very High Very High Very High
Pain 99 99.80 Very High Very High Very High
Death 42 99.60 Very High Very High Very High
Frailty 13 99.46 Very High Very High Very High
Diabetes Mellitus 401 99.32 Very High Very High Very High
Sepsis 66 99.08 Very High Very High Very High
Nervous System Injury 34 99.00 Very High Very High Very High
Osteoarthritis 50 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The latter is also associated with loss of nNOS and TH expression but by contrast, presents with increased expression of SP [26], suggesting regional variations in the effects of diabetes on the enteric nervous system.
Negative_regulation (loss) of Gene_expression (expression) of nNOS in enteric nervous system associated with diabetes mellitus and substance p
1) Confidence 0.55 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2442096 Disease Relevance 0.71 Pain Relevance 0.11
The absence of dystrophin, as seen in patients with Duchenne muscular dystrophy (DMD) and its animal equivalent the mdx mouse, leads to a significant reduction in skeletal muscle nNOS expression and in skeletal muscle blood flow (Brenman et al. 1995).
Negative_regulation (reduction) of Gene_expression (expression) of nNOS in blood associated with muscular dystrophy
2) Confidence 0.51 Published 2009 Journal Trends in Cardiovascular Medicine Section Body Doc Link PMC2984617 Disease Relevance 0.40 Pain Relevance 0.29
Fluoxetine inhibits dendrite atrophy of hippocampal neurons by decreasing nitric oxide synthase expression in rat depression model.
Negative_regulation (decreasing) of Gene_expression (expression) of nitric oxide synthase in dendrite associated with depression, frailty and fluoxetine
3) Confidence 0.51 Published 2001 Journal Acta Pharmacol. Sin. Section Title Doc Link 11749766 Disease Relevance 0.20 Pain Relevance 0.29
CONCLUSION: Fluoxetine, an antidepressant, renormalizes dendrite atrophy of hippocampal neurons by inhibiting nitric oxide synthase overexpression in rat chronic mild stress model.


Negative_regulation (inhibiting) of Gene_expression (overexpression) of nitric oxide synthase in neurons
4) Confidence 0.51 Published 2001 Journal Acta Pharmacol. Sin. Section Body Doc Link 11749766 Disease Relevance 0.14 Pain Relevance 0
It was also found that estrogen treatment down-regulates eNOS and nNOS expression in the rabbit vagina [41].
Negative_regulation (regulates) of Gene_expression (expression) of nNOS in vagina
5) Confidence 0.39 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC2907491 Disease Relevance 0 Pain Relevance 0.17
GLNVA also suppressed accumulation of iROS and up-regulated heme oxygenase-1 expression. 6-OHDA-induced overexpression of nNOS, iNOS, COX-2, and gp91(phox) was also reduced by GLNVA.
Negative_regulation (reduced) of Gene_expression (overexpression) of nNOS
6) Confidence 0.38 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17855475 Disease Relevance 0.64 Pain Relevance 0.16
In our patient with poorly controlled diabetes, the reduction in overall neuronal staining was accompanied by a significant loss of nNOS, but not SP expression, suggesting relatively specific injury to inhibitory neurons.
Negative_regulation (loss) of Gene_expression (expression) of nNOS in neurons associated with diabetes mellitus, injury and substance p
7) Confidence 0.35 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2442096 Disease Relevance 0.67 Pain Relevance 0.19
Most recently, a study of 36 male diabetic patients undergoing gastric resection showed significant loss of nNOS as well as SP expression; however, there was no information on whether these patients were symptomatic or had impaired gastric motility [20].
Negative_regulation (loss) of Gene_expression (expression) of nNOS associated with diabetes mellitus and substance p
8) Confidence 0.35 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2442096 Disease Relevance 0.76 Pain Relevance 0.20
As in the human penis, immunohistochemical staining of human clitoral cavernosal tissue has revealed NOS subtype expression, suggesting the involvement of NO in the regulation of clitoral smooth muscle contractility and the development of clitoral engorgement [41].
Negative_regulation (revealed) of Gene_expression (expression) of NOS in smooth muscle associated with female sexual arousal disorder
9) Confidence 0.33 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC2907491 Disease Relevance 0.10 Pain Relevance 0.15
The authors concluded that small amounts of transiently produced NO, perhaps produced by endothelial NOS, could potentially decrease the pain associated with OA.
Negative_regulation (decrease) of Gene_expression (produced) of NOS associated with pain and osteoarthritis
10) Confidence 0.27 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582805 Disease Relevance 1.91 Pain Relevance 1.26
inhibition may occur post-transcriptionally, whereas iNOS inhibition usually occurs at the transcriptional level.63 Many polyphenols, including 6-gingerol,64 EGCG,65 resveratrol,66 indole-3-carbinol,67 and oroxylin A,68 inhibit NOS expression in LPS-induced RAW264.7 cells.
Negative_regulation (inhibit) of Gene_expression (expression) of NOS
11) Confidence 0.27 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2562783 Disease Relevance 0.32 Pain Relevance 0.14
BMK extracts (10 microg/ml) inhibited cytokine-induced iNOS and nNOS expression.
Negative_regulation (inhibited) of Gene_expression (expression) of nNOS associated with cytokine
12) Confidence 0.24 Published 2006 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 16873093 Disease Relevance 0.51 Pain Relevance 0.24
The central role played by NO suggests that inhibition of inducible NOS expression would be beneficial but this needs to be demonstrated experimentally, especially because inhibition of endothelial NOS might worsen brain ischaemia.
Negative_regulation (inhibition) of Gene_expression (expression) of NOS in brain associated with brain hemorrhage
13) Confidence 0.22 Published 2005 Journal Crit Care Section Body Doc Link PMC1065096 Disease Relevance 0.85 Pain Relevance 0.03
In our study, the nerve injuries on both sides of corpus cavernosum significantly reduced the erectile function and expression level of NOS and cGMP.
Negative_regulation (reduced) of Gene_expression (expression) of NOS in nerve associated with nervous system injury
14) Confidence 0.20 Published 2010 Journal Int J Impot Res Section Body Doc Link PMC2959156 Disease Relevance 0.45 Pain Relevance 0
Inducible nitric oxide synthase and tumor necrosis factor expression were reduced after ischemic preconditioning in patients with unstable angina.
Negative_regulation (reduced) of Gene_expression (expression) of nitric oxide synthase
15) Confidence 0.20 Published 2008 Journal Eur J Cardiothorac Surg Section Body Doc Link 18842422 Disease Relevance 0 Pain Relevance 0
This correlated with decreased endothelial NOS expression and activity in diabetic vessels (Okon et al 2005).
Negative_regulation (decreased) of Gene_expression (expression) of NOS in vessels associated with diabetes mellitus
16) Confidence 0.19 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350146 Disease Relevance 2.32 Pain Relevance 0.17
Inducible NOS mRNA and protein expression levels in dura and pia mater were unaffected by stress.
Neg (unaffected) Negative_regulation (unaffected) of Gene_expression (expression) of NOS in pia mater associated with stress
17) Confidence 0.18 Published 2006 Journal Cephalalgia Section Abstract Doc Link 16396662 Disease Relevance 0.93 Pain Relevance 0.51
Effect of NMDA antagonists in NOS expression in monoarthritic rats
Negative_regulation (antagonists) of Gene_expression (expression) of NOS associated with antagonist
18) Confidence 0.15 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206346 Disease Relevance 0.16 Pain Relevance 0.54
In addition, wild-type p53 downregulates NOS and subsequent NO production through interaction with the region of the NOS2 promoter [47].
Negative_regulation (downregulates) of Neg (NO) Gene_expression (production) of NOS
19) Confidence 0.14 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064874 Disease Relevance 0.93 Pain Relevance 0.24
The above results suggested that the decrease of the activity and expression of NOS contributed to the inhibitory effect of midazolam on the development of morphine tolerance.
Negative_regulation (decrease) of Gene_expression (expression) of NOS associated with versed, tolerance and morphine
20) Confidence 0.13 Published 2005 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 15740792 Disease Relevance 0.06 Pain Relevance 1.13

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