INT90910

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Context Info
Confidence 0.82
First Reported 2000
Last Reported 2010
Negated 1
Speculated 4
Reported most in Abstract
Documents 150
Total Number 173
Disease Relevance 68.23
Pain Relevance 139.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin1) enzyme binding (Grin1) cytoplasm (Grin1)
Anatomy Link Frequency
spinal cord 23
spinal 20
neurons 11
dorsal horn 9
paw 6
Grin1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 1679 100.00 Very High Very High Very High
Spinal cord 1401 100.00 Very High Very High Very High
Dorsal horn 467 100.00 Very High Very High Very High
antagonist 465 100.00 Very High Very High Very High
Morphine 195 100.00 Very High Very High Very High
Dorsal horn neuron 151 100.00 Very High Very High Very High
spinothalamic tract 118 100.00 Very High Very High Very High
Inflammation 1207 99.92 Very High Very High Very High
allodynia 1263 99.88 Very High Very High Very High
Thermal hyperalgesia 265 99.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1255 99.92 Very High Very High Very High
Neuropathic Pain 2531 99.88 Very High Very High Very High
Hyperalgesia 1147 99.88 Very High Very High Very High
Injury 798 99.82 Very High Very High Very High
Nociception 1087 99.80 Very High Very High Very High
Frailty 146 99.60 Very High Very High Very High
Pain 1344 99.50 Very High Very High Very High
Dyspepsia 10 99.08 Very High Very High Very High
Pressure And Volume Under Development 121 98.32 Very High Very High Very High
Stress Incontinence 9 98.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EA stimulation produced an increase of serine phosphorylation of NMDAR NR-1 subunits in the spinal cord as compared with normal conditions.
Phosphorylation (phosphorylation) of NMDAR in spinal cord associated with electroacupuncture and spinal cord
1) Confidence 0.82 Published 2007 Journal Am. J. Chin. Med. Section Abstract Doc Link 18186585 Disease Relevance 0 Pain Relevance 0.88
However, the intrathecal injection of NMDAR antagonist D-2-amino-5-phosphonopentanoic acid significantly prevented serine phosphorylation of NMDAR NR-1 subunits induced by EA stimulation in the dorsal horn of spinal cord.
Phosphorylation (phosphorylation) of NMDAR in dorsal horn associated with antagonist, dorsal horn, electroacupuncture, spinal cord and intrathecal
2) Confidence 0.82 Published 2007 Journal Am. J. Chin. Med. Section Abstract Doc Link 18186585 Disease Relevance 0 Pain Relevance 0.92
We investigated whether the 2 Hz electroacupuncture (EA) analgesia is associated with phosphorylation of N-methyl-D-aspartate receptor (NMDAR) NR-1 subunits and NMDAR antagonism in the lumbar spinal cord of rats.
Phosphorylation (phosphorylation) of NMDAR in spinal cord associated with nmda receptor, electroacupuncture, spinal cord and analgesia
3) Confidence 0.82 Published 2007 Journal Am. J. Chin. Med. Section Abstract Doc Link 18186585 Disease Relevance 0 Pain Relevance 0.83
These results indicate that EA analgesia by stimulation of peripheral nerves may be involved in an increase of NR-1 serine phosphorylation in the dorsal horn of the spinal cord.
Phosphorylation (phosphorylation) of NR-1 in spinal cord associated with dorsal horn, electroacupuncture, spinal cord and analgesia
4) Confidence 0.82 Published 2007 Journal Am. J. Chin. Med. Section Abstract Doc Link 18186585 Disease Relevance 0 Pain Relevance 0.90
We investigated whether the 2 Hz electroacupuncture (EA) analgesia is associated with phosphorylation of N-methyl-D-aspartate receptor (NMDAR) NR-1 subunits and NMDAR antagonism in the lumbar spinal cord of rats.
Phosphorylation (phosphorylation) of NR-1 in spinal cord associated with nmda receptor, electroacupuncture, spinal cord and analgesia
5) Confidence 0.82 Published 2007 Journal Am. J. Chin. Med. Section Abstract Doc Link 18186585 Disease Relevance 0 Pain Relevance 0.83
We investigated whether the 2 Hz electroacupuncture (EA) analgesia is associated with phosphorylation of N-methyl-D-aspartate receptor (NMDAR) NR-1 subunits and NMDAR antagonism in the lumbar spinal cord of rats.
Phosphorylation (phosphorylation) of N-methyl-D-aspartate receptor in spinal cord associated with nmda receptor, electroacupuncture, spinal cord and analgesia
6) Confidence 0.82 Published 2007 Journal Am. J. Chin. Med. Section Abstract Doc Link 18186585 Disease Relevance 0 Pain Relevance 0.83
These findings suggest that excitotoxic lesions of the spinal cord induce both NR1 expression and NR1 serine phosphorylation.
Phosphorylation (phosphorylation) of NR1 in spinal cord associated with spinal cord
7) Confidence 0.82 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12946581 Disease Relevance 0.23 Pain Relevance 0.28
However, the injury-induced excessive grooming behavior is only associated with phosphorylation of the NR1 subunit.
Phosphorylation (phosphorylation) of NR1 associated with injury
8) Confidence 0.82 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12946581 Disease Relevance 0.32 Pain Relevance 0.27
This study examined the role of the intracellular calcium chelator, bis-(2-aminophenoxy)-ethane-N,N,N',N'-tetraacetic acid (BAPTA), in modulating the phosphorylation of the spinal N-methyl-d-aspartate receptor (NMDAR) NR1 and NR2B subunits after 2Hz electroacupuncture (EA) in rats.
Phosphorylation (phosphorylation) of NR1 in spinal associated with electroacupuncture
9) Confidence 0.82 Published 2010 Journal Acta Histochem. Section Abstract Doc Link 19056106 Disease Relevance 0 Pain Relevance 0.44
This study examined the role of the intracellular calcium chelator, bis-(2-aminophenoxy)-ethane-N,N,N',N'-tetraacetic acid (BAPTA), in modulating the phosphorylation of the spinal N-methyl-d-aspartate receptor (NMDAR) NR1 and NR2B subunits after 2Hz electroacupuncture (EA) in rats.
Phosphorylation (phosphorylation) of NMDAR in spinal associated with electroacupuncture
10) Confidence 0.82 Published 2010 Journal Acta Histochem. Section Abstract Doc Link 19056106 Disease Relevance 0 Pain Relevance 0.44
This study examined the role of the intracellular calcium chelator, bis-(2-aminophenoxy)-ethane-N,N,N',N'-tetraacetic acid (BAPTA), in modulating the phosphorylation of the spinal N-methyl-d-aspartate receptor (NMDAR) NR1 and NR2B subunits after 2Hz electroacupuncture (EA) in rats.
Phosphorylation (phosphorylation) of N-methyl-d-aspartate receptor in spinal associated with electroacupuncture
11) Confidence 0.82 Published 2010 Journal Acta Histochem. Section Abstract Doc Link 19056106 Disease Relevance 0 Pain Relevance 0.43
Phosphorylation of the N-methyl-D-aspartate (NMDA) receptor NR1 subunit (pNR1) in the spinal cord is associated with increased neuronal responsiveness, which underlies the process of central sensitization.
Phosphorylation (Phosphorylation) of NR1 in neuronal associated with central sensitization and spinal cord
12) Confidence 0.82 Published 2008 Journal Eur J Pain Section Abstract Doc Link 17933570 Disease Relevance 0.36 Pain Relevance 0.57
The present study investigated the role of inhibitor of protein phosphatases 1 and 2A on the modulation of the phosphorylation of the spinal N-methyl-D-aspartate receptor (NMDAR) NR1 and NR2B subunits following electroacupuncture (EA) stimulation in rats.
Phosphorylation (phosphorylation) of N-methyl-D-aspartate receptor in spinal associated with nmda receptor and electroacupuncture
13) Confidence 0.82 Published 2008 Journal Brain Res. Bull. Section Abstract Doc Link 18355647 Disease Relevance 0 Pain Relevance 0.63
As for the regional reaction of NMDAR subunits, a mean integrated optical density of phosphorylated NR1 and NR2B subunits was potentiated by calyculin A injections in the superficial laminae and neck region and superficial laminae and nucleus proprius, respectively.
Phosphorylation (phosphorylated) of NR1 in nucleus
14) Confidence 0.82 Published 2008 Journal Brain Res. Bull. Section Abstract Doc Link 18355647 Disease Relevance 0 Pain Relevance 0.75
The present study investigated the role of inhibitor of protein phosphatases 1 and 2A on the modulation of the phosphorylation of the spinal N-methyl-D-aspartate receptor (NMDAR) NR1 and NR2B subunits following electroacupuncture (EA) stimulation in rats.
Phosphorylation (phosphorylation) of NR1 in spinal associated with nmda receptor and electroacupuncture
15) Confidence 0.82 Published 2008 Journal Brain Res. Bull. Section Abstract Doc Link 18355647 Disease Relevance 0 Pain Relevance 0.63
The present study investigated the role of inhibitor of protein phosphatases 1 and 2A on the modulation of the phosphorylation of the spinal N-methyl-D-aspartate receptor (NMDAR) NR1 and NR2B subunits following electroacupuncture (EA) stimulation in rats.
Phosphorylation (phosphorylation) of NMDAR in spinal associated with nmda receptor and electroacupuncture
16) Confidence 0.82 Published 2008 Journal Brain Res. Bull. Section Abstract Doc Link 18355647 Disease Relevance 0 Pain Relevance 0.63
At 60 min after the termination of EA stimulation, the levels of c-fos, serine phosphorylation of NR1 and NR2B by Western analysis had increased in the L(4-5) segments of the spinal cord after EA treatment.
Phosphorylation (phosphorylation) of NR1 in spinal cord associated with electroacupuncture and spinal cord
17) Confidence 0.82 Published 2008 Journal Brain Res. Bull. Section Abstract Doc Link 18355647 Disease Relevance 0 Pain Relevance 0.79
These results demonstrate the distinct expression of phospho-NR1 subunits in different populations of striatal projection neurons and interneurons at variable levels in normal rats; they also demonstrate that phosphorylation of NR1, at least on serine 896 and 890 sites, is sensitive to drug exposure.
Phosphorylation (phosphorylation) of NR1 in interneurons associated with projection neuron
18) Confidence 0.81 Published 2004 Journal J. Comp. Neurol. Section Abstract Doc Link 15174082 Disease Relevance 0 Pain Relevance 0.52
In this study, Western blots, immunofluorescence double labeling, and the retrograde tracing method were used to examine whether phosphorylation of NMDA receptor 1 (NR1) subunits increases in spinal cord tissue and spinal dorsal horn neurons, especially in STT cells, after injection of capsaicin (CAP) into the glabrous skin of one hindpaw of anesthetized rats.
Spec (whether) Phosphorylation (phosphorylation) of NMDA receptor 1 in spinal associated with spinothalamic tract, qutenza, nmda receptor, dorsal horn neuron and spinal cord
19) Confidence 0.81 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10995844 Disease Relevance 0.18 Pain Relevance 1.05
Enhanced phosphorylation of NMDA receptor 1 subunits in spinal cord dorsal horn and spinothalamic tract neurons after intradermal injection of capsaicin in rats.
Phosphorylation (phosphorylation) of NMDA receptor 1 in spinal cord dorsal horn associated with qutenza, spinothalamic tract neurons, nmda receptor, dorsal horn and spinal cord
20) Confidence 0.81 Published 2000 Journal J. Neurosci. Section Title Doc Link 10995844 Disease Relevance 0.18 Pain Relevance 1.12

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