INT90911

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Context Info
Confidence 0.70
First Reported 2000
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 62
Total Number 75
Disease Relevance 27.45
Pain Relevance 59.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin1) enzyme binding (Grin1) cytoplasm (Grin1)
Anatomy Link Frequency
spinal 14
spinal cord 14
neurons 12
dorsal horn 10
spinal cord dorsal horn 10
Grin1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 619 100.00 Very High Very High Very High
Spinal cord 522 100.00 Very High Very High Very High
Kinase C 295 100.00 Very High Very High Very High
Dorsal horn 205 100.00 Very High Very High Very High
qutenza 131 100.00 Very High Very High Very High
ketamine 1034 99.98 Very High Very High Very High
Spinal nerve ligature 688 99.98 Very High Very High Very High
Inflammation 402 99.98 Very High Very High Very High
amygdala 31 99.96 Very High Very High Very High
central sensitization 250 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 423 99.98 Very High Very High Very High
Injury 349 99.98 Very High Very High Very High
Frailty 55 99.98 Very High Very High Very High
Colitis 3 99.96 Very High Very High Very High
Nociception 411 99.80 Very High Very High Very High
Pain 522 99.74 Very High Very High Very High
Neuropathic Pain 1293 99.36 Very High Very High Very High
Hyperalgesia 473 99.32 Very High Very High Very High
Nervous System Injury 102 98.48 Very High Very High Very High
Stress Incontinence 3 98.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that EA analgesia by stimulation of peripheral nerves may be involved in an increase of NR-1 serine phosphorylation in the dorsal horn of the spinal cord.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of NR-1 in spinal cord associated with dorsal horn, electroacupuncture, spinal cord and analgesia
1) Confidence 0.70 Published 2007 Journal Am. J. Chin. Med. Section Abstract Doc Link 18186585 Disease Relevance 0 Pain Relevance 0.91
In this study, Western blots, immunofluorescence double labeling, and the retrograde tracing method were used to examine whether phosphorylation of NMDA receptor 1 (NR1) subunits increases in spinal cord tissue and spinal dorsal horn neurons, especially in STT cells, after injection of capsaicin (CAP) into the glabrous skin of one hindpaw of anesthetized rats.
Spec (whether) Positive_regulation (increases) of Spec (whether) Phosphorylation (phosphorylation) of NR1 in spinal associated with spinothalamic tract, qutenza, nmda receptor, dorsal horn neuron and spinal cord
2) Confidence 0.69 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10995844 Disease Relevance 0.18 Pain Relevance 1.06
Enhanced phosphorylation of NMDA receptor 1 subunits in spinal cord dorsal horn and spinothalamic tract neurons after intradermal injection of capsaicin in rats.
Positive_regulation (Enhanced) of Phosphorylation (phosphorylation) of NMDA receptor 1 in spinal cord dorsal horn associated with qutenza, spinothalamic tract neurons, nmda receptor, dorsal horn and spinal cord
3) Confidence 0.69 Published 2000 Journal J. Neurosci. Section Title Doc Link 10995844 Disease Relevance 0.18 Pain Relevance 1.12
Western blots showed that pretreatment with the PKC inhibitor caused a decrease in CAP-induced phosphorylation of NR1 protein.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of NR1 protein associated with kinase c and qutenza
4) Confidence 0.69 Published 2004 Journal Brain Res. Section Abstract Doc Link 15312791 Disease Relevance 0 Pain Relevance 1.09
To see if protein kinase C (PKC) also participates in the phosphorylation of NR1, we used electron microscopic techniques to determine further where the phosphorylated NR1 subunits (pNR1) are expressed in the spinothalamic tract (STT) cells and immunohistochemistry to examine whether a PKC inhibitor, chelerythrine chloride, blocks the enhanced phosphorylation of NR1 on serine 896.
Spec (whether) Positive_regulation (enhanced) of Phosphorylation (phosphorylation) of NR1 associated with spinothalamic tract and kinase c
5) Confidence 0.69 Published 2004 Journal Brain Res. Section Abstract Doc Link 15312791 Disease Relevance 0 Pain Relevance 0.97
induces NR1 phosphorylation, which is blocked by an IL-1R antagonist [12].
Positive_regulation (induces) of Phosphorylation (phosphorylation) of NR1 associated with antagonist
6) Confidence 0.67 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.43 Pain Relevance 0.87
As a functional subunit of NMDAR, NR1 phosphorylation is significantly increased in the ipsilateral spinal cord after nerve injury and coincides with mechanical allodynia [28].
Positive_regulation (increased) of Phosphorylation (phosphorylation) of NR1 in nerve associated with nervous system injury, allodynia and spinal cord
7) Confidence 0.67 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 1.05 Pain Relevance 1.77
We have recently reported that there is enhanced phosphorylation of NR1 on serine 897 in dorsal horn and spinothalamic tract (STT) neurons after intradermal injection of capsaicin (CAP) in rats [Zou et al. (2000) J.
Positive_regulation (enhanced) of Phosphorylation (phosphorylation) of NR1 in neurons associated with spinothalamic tract, qutenza and dorsal horn
8) Confidence 0.65 Published 2002 Journal Neuroscience Section Abstract Doc Link 12435416 Disease Relevance 0 Pain Relevance 0.75
In this study, western blots and immunofluorescence staining were employed to observe if pretreatment with a PKA inhibitor, N-[2-((p-bromocinnamyl)amino)ethyl]-5-isoquinolinesulfonamide, HCl (H89), blocks the enhanced phosphorylation of NR1 on serine 897 following injection of CAP into the glabrous skin of one hind paw of anesthetized rats.
Positive_regulation (enhanced) of Phosphorylation (phosphorylation) of NR1 in paw associated with qutenza
9) Confidence 0.65 Published 2002 Journal Neuroscience Section Abstract Doc Link 12435416 Disease Relevance 0 Pain Relevance 1.00
This finding is consistent with our data demonstrating that when N1 is used as the precipitating epitope we do not find any injury induced phosphorylation of NR1 (Figure 3A) suggesting an absence of C1 in the precipitated protein.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of NR1 associated with injury
10) Confidence 0.65 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.47 Pain Relevance 0.24
NR1 protein in grooming rats was not elevated, but there was a significant increase in NR1 serine phosphorylation.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of NR1
11) Confidence 0.61 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12946581 Disease Relevance 0.24 Pain Relevance 0.29
In addition, IT injection of the alpha-2 adrenoceptor antagonist, idazoxan (40 microg/rat) 10 min before clonidine injection completely reversed clonidine's antihyperalgesic and antiallodynic effects, as well as clonidine's suppressive effect on CCI-induced NR1 phosphorylation in the spinal cord dorsal horn.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of NR1 in spinal cord dorsal horn
12) Confidence 0.59 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18633054 Disease Relevance 0.05 Pain Relevance 0
Ketamine could block Ca2+ influx through the NMDA receptor, and then the lowered intracellular Ca2+ decreases the activity of protein kinase C (PKC) and some other intracellular signals [31,32].Inhibition of PKC activity could block capsicin-induced phosphorylation of NR1 [33].
Positive_regulation (induced) of Phosphorylation (phosphorylation) of NR1 associated with kinase c, ketamine and nmda receptor
13) Confidence 0.58 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.62 Pain Relevance 1.59
Peripheral noxious stimulation induces phosphorylation of the NMDA receptor NR1 subunit at the PKC-dependent site, serine-896, in spinal cord dorsal horn neurons.
Positive_regulation (induces) of Phosphorylation (phosphorylation) of NMDA receptor NR1 subunit in spinal cord dorsal horn associated with nociceptor, nmda receptor, dorsal horn neuron and spinal cord
14) Confidence 0.57 Published 2004 Journal Eur. J. Neurosci. Section Title Doc Link 15233747 Disease Relevance 0.35 Pain Relevance 0.84
We now show that a noxious heat stimulus applied to the rat hindpaw induces phosphorylation of the NMDAR NR1 subunit at a protein kinase C (PKC)-dependent site, serine-896, in superficial dorsal horn neurons.
Positive_regulation (induces) of Phosphorylation (phosphorylation) of NMDAR NR1 subunit in neurons associated with kinase c and dorsal horn neuron
15) Confidence 0.57 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15233747 Disease Relevance 0.37 Pain Relevance 0.70
Similarly, Brenner and colleagues demonstrated that noxious heat applied to the hind paw of rats produces an increase in serine 896 phosphorylation of NR1 [14].
Positive_regulation (increase) of Phosphorylation (phosphorylation) of NR1 in paw
16) Confidence 0.56 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.13 Pain Relevance 0.74
Hindpaw inflammation induces tyrosine phosphorylation (tyr-P) of the NMDA receptor (NMDAR) 2B (NR2B) subunit in the rat spinal dorsal horn that is closely related to the initiation and development of hyperalgesia.
Positive_regulation (induces) of Phosphorylation (phosphorylation) of NMDAR in dorsal horn associated with hyperalgesia, inflammation, spinal dorsal horn and nmda receptor
17) Confidence 0.51 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15483135 Disease Relevance 0.43 Pain Relevance 0.67
EA stimulation produced an increase of serine phosphorylation of NMDAR NR-1 subunits in the spinal cord as compared with normal conditions.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of NMDAR in spinal cord associated with electroacupuncture and spinal cord
18) Confidence 0.50 Published 2007 Journal Am. J. Chin. Med. Section Abstract Doc Link 18186585 Disease Relevance 0 Pain Relevance 0.88
However, the intrathecal injection of NMDAR antagonist D-2-amino-5-phosphonopentanoic acid significantly prevented serine phosphorylation of NMDAR NR-1 subunits induced by EA stimulation in the dorsal horn of spinal cord.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of NMDAR in dorsal horn associated with antagonist, dorsal horn, electroacupuncture, spinal cord and intrathecal
19) Confidence 0.50 Published 2007 Journal Am. J. Chin. Med. Section Abstract Doc Link 18186585 Disease Relevance 0 Pain Relevance 0.93
These findings suggest that excitotoxic lesions of the spinal cord induce both NR1 expression and NR1 serine phosphorylation.
Positive_regulation (induce) of Phosphorylation (phosphorylation) of NR1 in spinal cord associated with spinal cord
20) Confidence 0.50 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12946581 Disease Relevance 0.23 Pain Relevance 0.29

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