INT90926

Context Info Confidence 0.45 First Reported 2000 Last Reported 2011 Negated 0 Speculated 1 Reported most in Body Documents 12 Total Number 13 Disease Relevance 4.99 Pain Relevance 1.74

cell differentiation (GLI2) cell proliferation (GLI2) nucleus (GLI2) intracellular (GLI2) cilium (GLI2) cytoplasm (GLI2)

Anatomy Link Frequency THP-1 8 macrophages 2 SH-SY5Y 1 GLI2 (Homo sapiens)

Pain Link Frequency Relevance Heat Kappa opioid receptor 8 99.44 Inflammation 69 99.16 agonist 13 98.16 rheumatoid arthritis 145 97.60 opioid receptor 1 96.68 cINOD 32 93.76 Opioid 1 92.04 diclofenac 4 89.52 COX-2 inhibitor 28 89.40 Abeta 1 88.56

Disease Link Frequency Relevance Heat Apoptosis 117 99.96 Necrosis 12 99.40 INFLAMMATION 89 99.16 Neuroblastoma 1 98.64 Rheumatoid Arthritis 148 97.60 Cancer 113 96.72 Metastasis 31 95.92 Reprotox - General 1 1 95.44 Skin Cancer 72 89.60 Alzheimer's Dementia 1 87.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We compared the neuroprotective activity of S- and R-enantiomers of flurbiprofen and ibuprofen in a standard assay where secretions from activated human THP-1 or microglial cells are toxic to neuroblastoma SH-SY5Y cells.

Positive_regulation (activated) of THP-1 in SH-SY5Y associated with neuroblastoma

1) Confidence 0.45 Published 2004 Journal J. Neuroimmunol. Section Abstract Doc Link 15223239 Disease Relevance 0.42 Pain Relevance 0.30

While other genes may also increase in addition to Gli2 and PTHrP, we found minimal changes in many of the genes identified previously to be associated with metastasis to bone [29].

Spec (may) Positive_regulation (increase) of Gli2 associated with metastasis

2) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.71 Pain Relevance 0

All the other mNSAIDs, including nimesulide (NIM-03), fluosulide (CGP28238), FK3311 and NS398, also rescued THP-1 from Leu-OME mediated killing, although to a lesser degree.

Positive_regulation (rescued) of THP-1 in THP-1

3) Confidence 0.22 Published 2000 Journal Immunopharmacology Section Abstract Doc Link 10996026 Disease Relevance 0.31 Pain Relevance 0.24

Inhibition of L-leucine methyl ester mediated killing of THP-1, a human monocytic cell line, by a new anti-inflammatory drug, T614.

Positive_regulation (mediated) of THP-1 in THP-1 associated with inflammation

4) Confidence 0.22 Published 2000 Journal Immunopharmacology Section Title Doc Link 10996026 Disease Relevance 0.33 Pain Relevance 0.19

While it inhibits protein kinase A (PKA-) mediated phosphorylation, it also stabilizes GLI2.

Positive_regulation (stabilizes) of GLI2

5) Confidence 0.12 Published 2011 Journal Journal of Skin Cancer Section Body Doc Link PMC3021865 Disease Relevance 0.83 Pain Relevance 0

Stimulation of the THP-1 cells with a kappa-opioid receptor-selective agonist exerted a Gi-dependent activation of c-Jun N-terminal kinase (JNK).

Positive_regulation (Stimulation) of THP-1 in THP-1 associated with agonist and kappa opioid receptor

6) Confidence 0.11 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14996948 Disease Relevance 0.07 Pain Relevance 0.40

Stimulation of THP-1 with PHA was therefore used in the subsequent transfection experiments.

Positive_regulation (Stimulation) of THP-1 in THP-1

7) Confidence 0.08 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065333 Disease Relevance 0.40 Pain Relevance 0.17

To assess the role of survivin in the inflammatory process, the human mononuclear cell line THP-1 was transfected with oligonucleotides targeting different regions of survivin mRNA.

Positive_regulation (transfected) of THP-1 in THP-1 associated with inflammation

8) Confidence 0.05 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065333 Disease Relevance 0.37 Pain Relevance 0.16

THP-1 cells then were subjected to the experimental conditions described or were differentiated into adherent macrophages (phorbol dibutyrate, 0.3 ?

Positive_regulation (subjected) of THP-1 in macrophages

9) Confidence 0.03 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0.08 Pain Relevance 0

factor, can induce THP-1 apoptosis and necrosis by inducing PPAR?

Positive_regulation (induce) of THP-1 in THP-1 associated with necrosis and apoptosis

10) Confidence 0.03 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 1.32 Pain Relevance 0.11

THP-1 macrophages showed a significant increase in foam cell transformation in the presence of NS398 compared to control (78.9% ± 4.4% at 10 ?

Positive_regulation (increase) of THP-1 in macrophages

11) Confidence 0.03 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0 Pain Relevance 0.13

In addition, CRLPs lacking apoB48, but containing apoE from the appropriate species, have been found to have effects which mimic those of physiological remnants in rat hepatocytes and pig endothelial cells [23,35], and our earlier work has shown that CRLPs cause extensive lipid accumulation in THP-1 macrophages and human monocyte derived macrophages (HMDM) which is comparable to that found in experiments with physiological CMR from rats and the murine macrophage cell line J774 [24,36].

Positive_regulation (accumulation) of THP-1 in THP-1

12) Confidence 0.03 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC1906864 Disease Relevance 0.07 Pain Relevance 0

B transcriptional activation in both Raw 264.7 cells (Fig. 4A) and THP-1 cells (Fig. 4B) by 20 ?

Positive_regulation (activation) of THP-1 in THP-1

13) Confidence 0.01 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2442592 Disease Relevance 0.06 Pain Relevance 0.03

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