INT90932

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Context Info
Confidence 0.41
First Reported 2000
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.36
Pain Relevance 2.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk)
Anatomy Link Frequency
substantia nigra 4
striatum 2
dorsal 1
ventral 1
Penk (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 20 100.00 Very High Very High Very High
Enkephalin 6 100.00 Very High Very High Very High
Substantia nigra 6 100.00 Very High Very High Very High
monoamine 4 100.00 Very High Very High Very High
Nicotine 14 99.26 Very High Very High Very High
Neurotransmitter 2 84.08 Quite High
antagonist 2 77.20 Quite High
Glutamate receptor 2 75.00 Quite High
Glutamate 6 72.72 Quite High
gABA 6 65.92 Quite High
Disease Link Frequency Relevance Heat
Toxicity 6 80.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tamoxifen at 50 microg reduced the methamphetamine effect on striatal dopamine concentration, dopamine transporter specific binding and prevented the increase in preproenkephalin mRNA levels; in the substantia nigra tamoxifen prevented the decrease of dopamine transporter mRNA levels.
Negative_regulation (prevented) of Positive_regulation (increase) of preproenkephalin mRNA in substantia nigra associated with dopamine and substantia nigra
1) Confidence 0.41 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17825264 Disease Relevance 0.23 Pain Relevance 0.60
Methamphetamine reduced striatal dopamine and its metabolites 3,4-dihydroxyphenylacetic acid and homovanillic acid concentrations, striatal and substantia nigra dopamine and vesicular monoamine transporter specific binding as well substantia nigra dopamine and vesicular monoamine transporter mRNA levels and increased striatal preproenkephalin mRNA levels.
Negative_regulation (reduced) of Positive_regulation (increased) of preproenkephalin mRNA in substantia nigra associated with dopamine, substantia nigra and monoamine
2) Confidence 0.26 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17825264 Disease Relevance 0.13 Pain Relevance 0.63
A single dose of nicotine given to mice induces first a rapid decrease (presumed release/enhanced degradation) and then a rise (presumed synthesis/enhanced accumulation) of met-enkephalin (Met-Enk) in dorsal and ventral striatum observed at 30 and 60 min post-treatment, respectively.
Negative_regulation (decrease) of in dorsal Positive_regulation (accumulation) of Met-Enk in striatum associated with nicotine and enkephalin
3) Confidence 0.24 Published 2000 Journal Brain Res. Section Abstract Doc Link 10996137 Disease Relevance 0 Pain Relevance 0.72
A single dose of nicotine given to mice induces first a rapid decrease (presumed release/enhanced degradation) and then a rise (presumed synthesis/enhanced accumulation) of met-enkephalin (Met-Enk) in dorsal and ventral striatum observed at 30 and 60 min post-treatment, respectively.
Negative_regulation (decrease) of in ventral Positive_regulation (accumulation) of Met-Enk in striatum associated with nicotine and enkephalin
4) Confidence 0.08 Published 2000 Journal Brain Res. Section Abstract Doc Link 10996137 Disease Relevance 0 Pain Relevance 0.72

General Comments

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