INT90934

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Context Info
Confidence 0.24
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk)
Anatomy Link Frequency
striatum 2
dorsal 1
ventral 1
Penk (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 4 100.00 Very High Very High Very High
Nicotine 14 99.26 Very High Very High Very High
Neurotransmitter 2 84.08 Quite High
antagonist 2 77.20 Quite High
Dopamine 2 76.00 Quite High
Glutamate receptor 2 75.00 Quite High
Glutamate 6 72.72 Quite High
gABA 6 65.92 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A single dose of nicotine given to mice induces first a rapid decrease (presumed release/enhanced degradation) and then a rise (presumed synthesis/enhanced accumulation) of met-enkephalin (Met-Enk) in dorsal and ventral striatum observed at 30 and 60 min post-treatment, respectively.
Negative_regulation (decrease) of in dorsal Protein_catabolism (degradation) of Met-Enk in striatum associated with nicotine and enkephalin
1) Confidence 0.24 Published 2000 Journal Brain Res. Section Abstract Doc Link 10996137 Disease Relevance 0 Pain Relevance 0.72
A single dose of nicotine given to mice induces first a rapid decrease (presumed release/enhanced degradation) and then a rise (presumed synthesis/enhanced accumulation) of met-enkephalin (Met-Enk) in dorsal and ventral striatum observed at 30 and 60 min post-treatment, respectively.
Negative_regulation (decrease) of in ventral Protein_catabolism (degradation) of Met-Enk in striatum associated with nicotine and enkephalin
2) Confidence 0.08 Published 2000 Journal Brain Res. Section Abstract Doc Link 10996137 Disease Relevance 0 Pain Relevance 0.72

General Comments

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