INT90937

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Context Info
Confidence 0.59
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 34
Total Number 36
Disease Relevance 22.74
Pain Relevance 18.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) transport (Trpv1) plasma membrane (Trpv1)
transmembrane transport (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
neurons 20
skin 4
sensory neurons 2
spinal cord 2
pore 2
Trpv1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 758 100.00 Very High Very High Very High
dorsal root ganglion 506 100.00 Very High Very High Very High
Kinase C 45 99.84 Very High Very High Very High
hypoalgesia 155 99.68 Very High Very High Very High
imagery 17 99.36 Very High Very High Very High
fifth nerve 4 99.16 Very High Very High Very High
Inflammation 262 99.00 Very High Very High Very High
agonist 87 98.92 Very High Very High Very High
tetrodotoxin 5 98.76 Very High Very High Very High
addiction 5 98.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 1305 100.00 Very High Very High Very High
Hyperalgesia 673 100.00 Very High Very High Very High
Ganglion Cysts 607 100.00 Very High Very High Very High
Hypoalagesia 156 99.68 Very High Very High Very High
Obesity 12 99.48 Very High Very High Very High
Neurogenic Inflammation 9 99.36 Very High Very High Very High
Nociception 155 99.04 Very High Very High Very High
INFLAMMATION 297 99.00 Very High Very High Very High
Disease 90 98.72 Very High Very High Very High
Diabetic Neuropathy 25 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The significant finding of this study is that the predominant phenotype observed over time is thermal hypoalgesia as a result of reduced TRPV1 expression and function.
Negative_regulation (reduced) of Gene_expression (expression) of TRPV1 associated with hypoalgesia
1) Confidence 0.59 Published 2008 Journal Mol Pain Section Body Doc Link PMC2275252 Disease Relevance 1.31 Pain Relevance 0.33
Consequences of enhanced and reduced TRPV1 expression and function other than abnormal thermal sensation
Negative_regulation (reduced) of Gene_expression (expression) of TRPV1
2) Confidence 0.59 Published 2008 Journal Mol Pain Section Body Doc Link PMC2275252 Disease Relevance 0.94 Pain Relevance 0.28
Expression of TRPV1 is elevated in the fibers of the dermis of skin from hyperalgesic diabetic mice and decreased in skin from hypoalgesic mice compared to control non-diabetic mice (Fig. 8A).
Negative_regulation (decreased) of Gene_expression (Expression) of TRPV1 in skin associated with hyperalgesia and diabetes mellitus
3) Confidence 0.59 Published 2008 Journal Mol Pain Section Body Doc Link PMC2275252 Disease Relevance 1.33 Pain Relevance 0.28
Based on this observation, the long lasting hypoalgesic phenotype could be explained by insulin deficiency leading to downregulation of TRPV1 expression and function.
Negative_regulation (downregulation) of Gene_expression (expression) of TRPV1
4) Confidence 0.59 Published 2008 Journal Mol Pain Section Body Doc Link PMC2275252 Disease Relevance 0.88 Pain Relevance 0.13
Immunohistochemical labeling of spinal cord lamina I and II, dorsal root ganglion (DRG), and paw skin from hyperalgesic and hypoalgesic mice reveal increased and decreased TRPV1 expression, respectively.
Negative_regulation (decreased) of Gene_expression (expression) of TRPV1 in DRG associated with ganglion cysts, dorsal root ganglion, hyperalgesia and spinal cord
5) Confidence 0.59 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2275252 Disease Relevance 1.86 Pain Relevance 0.79
The reduced TRPV1 expression in visceral adipose tissue from obese humans was accompanied by reduced capsaicin-induced calcium influx.
Negative_regulation (reduced) of Gene_expression (expression) of TRPV1 in adipose tissue associated with qutenza and obesity
6) Confidence 0.58 Published 2007 Journal Circ. Res. Section Abstract Doc Link 17347480 Disease Relevance 0.97 Pain Relevance 0.46
70%–80% reduction in TRPV1 protein expression and in the number of TRPV1-expressing neurons produced by prolonged (?
Negative_regulation (reduction) of Gene_expression (expression) of TRPV1 in neurons
7) Confidence 0.58 Published 2009 Journal Neuroscience Section Body Doc Link PMC2724038 Disease Relevance 0 Pain Relevance 0.67
We found in the present study that overnight exposure of cultured primary sensory neurons to capsaicin reduced TRPV1 mRNA expression by ?
Negative_regulation (reduced) of Gene_expression (expression) of TRPV1 mRNA in primary sensory neurons associated with qutenza
8) Confidence 0.58 Published 2009 Journal Neuroscience Section Body Doc Link PMC2724038 Disease Relevance 0 Pain Relevance 0.64
Conversely, downregulation of VR1 expression and/or activity is a promising therapeutic strategy for novel analgesic drugs.
Negative_regulation (downregulation) of Gene_expression (expression) of VR1 associated with analgesic
9) Confidence 0.57 Published 2002 Journal Curr. Opin. Neurobiol. Section Abstract Doc Link 12139983 Disease Relevance 1.01 Pain Relevance 0.91
We report that synthetic arginine-rich hexapeptides block heterologously expressed VR-1 channels with submicromolar efficacy in a weak voltage-dependent manner, consistent with a binding site located near/at the entryway of the aqueous pore.
Negative_regulation (block) of Gene_expression (expressed) of VR-1 in pore
10) Confidence 0.52 Published 2000 Journal FEBS Lett. Section Abstract Doc Link 10996311 Disease Relevance 0.19 Pain Relevance 0.40
In L-CKO mice, we found that TRPV1high expression was only reduced by 75%, meaning that there was a 25% of "restoration" in L-CKO mice (Fig. 1D-E).
Negative_regulation (reduced) of Gene_expression (expression) of TRPV1high
11) Confidence 0.50 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0 Pain Relevance 0.38
Expression of shRNAs targeting TRPV1 in transgenic (tg) mice was proven by RNase protection assays, and TRPV1 downregulation was confirmed by reduced expression of TRPV1 mRNA and lack of receptor agonist binding in spinal cord membranes.
Negative_regulation (reduced) of Gene_expression (expression) of TRPV1 in spinal cord associated with targeted disruption, agonist and spinal cord
12) Confidence 0.43 Published 2008 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 18249134 Disease Relevance 0.68 Pain Relevance 0.32
The capsaicin treatment downregulated TRPV1 mRNA expression by the same extent.


Negative_regulation (downregulated) of Gene_expression (expression) of TRPV1 mRNA associated with qutenza
13) Confidence 0.43 Published 2009 Journal Neuroscience Section Body Doc Link PMC2724038 Disease Relevance 0 Pain Relevance 0.88
Resiniferatoxin (RTX) binding, a measure of TRPV1 expression is increased and decreased in DRG and paw skin of hyperalgesic and hypoalgesic mice, respectively.
Negative_regulation (measure) of Gene_expression (expression) of TRPV1 in skin associated with dorsal root ganglion and hyperalgesia
14) Confidence 0.43 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2275252 Disease Relevance 1.96 Pain Relevance 0.84
Determination of TRPV1 expression using immunohistochemistry
Negative_regulation (Determination) of Gene_expression (expression) of TRPV1
15) Confidence 0.43 Published 2008 Journal Mol Pain Section Body Doc Link PMC2275252 Disease Relevance 1.19 Pain Relevance 0.25
Possible down stream events leading to altered TRPV1 expression
Negative_regulation (altered) of Gene_expression (expression) of TRPV1
16) Confidence 0.43 Published 2008 Journal Mol Pain Section Body Doc Link PMC2275252 Disease Relevance 0.81 Pain Relevance 0.07
Collectively, these data suggest that the thermal hypoalgesia observed secondary to protracted dysglycemia in STZ-treated mice in our study is not due to loss of TRPV1 positive DRG neurons, however ectopic expression of TRPV1 on large diameter neurons cannot be excluded as a possible explanation for the increased TRPV1 expression observed among DRG isolated from hyperalgesic diabetic mice.
Negative_regulation (loss) of Gene_expression (expression) of TRPV1 in neurons associated with dorsal root ganglion, hyperalgesia, diabetes mellitus and hypoalgesia
17) Confidence 0.43 Published 2008 Journal Mol Pain Section Body Doc Link PMC2275252 Disease Relevance 1.35 Pain Relevance 0.34
Evidence of TRPV1 involvement in the altered thermal nociception of diabetic mice
Negative_regulation (Evidence) of Gene_expression (involvement) of TRPV1 associated with nociception and diabetes mellitus
18) Confidence 0.43 Published 2008 Journal Mol Pain Section Body Doc Link PMC2275252 Disease Relevance 1.47 Pain Relevance 0.53
Collectively, these data suggest that the thermal hypoalgesia observed secondary to protracted dysglycemia in STZ-treated mice in our study is not due to loss of TRPV1 positive DRG neurons, however ectopic expression of TRPV1 on large diameter neurons cannot be excluded as a possible explanation for the increased TRPV1 expression observed among DRG isolated from hyperalgesic diabetic mice.
Negative_regulation (loss) of Gene_expression (expression) of TRPV1 in neurons associated with dorsal root ganglion, hyperalgesia, diabetes mellitus and hypoalgesia
19) Confidence 0.43 Published 2008 Journal Mol Pain Section Body Doc Link PMC2275252 Disease Relevance 1.36 Pain Relevance 0.34
To elucidate the roles of the hot and cold thermoreceptors in sensory neurons, we first assessed TRPV1, TRPM8, and TRPA1 mRNA expression in rat and mouse peripheral tissues.
Negative_regulation (assessed) of Gene_expression (expression) of TRPV1 in sensory neurons
20) Confidence 0.42 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 1.26 Pain Relevance 0.84

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