INT90938

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Context Info
Confidence 0.72
First Reported 2000
Last Reported 2011
Negated 5
Speculated 1
Reported most in Body
Documents 48
Total Number 49
Disease Relevance 15.76
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Eng) cell motility (Eng) cell adhesion (Eng)
nucleus (Eng) cytoplasm (Eng)
Anatomy Link Frequency
stem cells 9
retina 6
vessels 3
blood 2
macrophages 1
Eng (Mus musculus)
Pain Link Frequency Relevance Heat
Angina 2 92.28 High High
Neurotransmitter 18 90.80 High High
Pain score 3 87.72 High High
Pain 42 85.64 High High
Neuropathic pain 3 73.12 Quite High
ischemia 114 72.28 Quite High
Inflammatory response 6 65.80 Quite High
dexamethasone 16 60.48 Quite High
chemokine 9 60.04 Quite High
Inflammation 92 53.88 Quite High
Disease Link Frequency Relevance Heat
Osteoporosis 207 100.00 Very High Very High Very High
Apoptosis 560 99.92 Very High Very High Very High
Congenital Anomalies 53 99.92 Very High Very High Very High
Sickle Cell Anemia 6 99.38 Very High Very High Very High
Malignant Neoplastic Disease 20 99.32 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 152 98.88 Very High Very High Very High
Reprotox - General 3 18 98.88 Very High Very High Very High
Transitional Cell Carcinoma 1 98.88 Very High Very High Very High
Prostate Cancer 6 98.00 Very High Very High Very High
Atherosclerosis 4 97.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased apoptosis in sEng-expressing mice was supported by a significant increase in cleaved-caspase 3 by western blot analysis of whole retinas (Figure 8B and 8C).
Gene_expression (expressing) of sEng in retinas associated with apoptosis
1) Confidence 0.72 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.50 Pain Relevance 0
Analysis of sEng-expressing mice seven days after virus administration exhibited a-wave amplitude similar to Ad-null infected control, whereas the b-wave amplitude was significantly decreased (687.1+/?
Gene_expression (expressing) of sEng
2) Confidence 0.72 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.52 Pain Relevance 0
Transmission electron microscopy (TEM) analysis of the superficial vascular plexus in sEng-expressing mice revealed structural alterations in tight junctions between microvascular ECs (Figure 3C).
Gene_expression (expressing) of sEng
3) Confidence 0.72 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0 Pain Relevance 0.04
To determine if the reduced retinal perfusion in sEng-expressing mice was associated with retinal dysfunction, the electrical response of the retina to a light stimulus was measured via electroretinogram (ERG).
Gene_expression (expressing) of sEng in retina
4) Confidence 0.63 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.45 Pain Relevance 0
In contrast, retinal microvessels of sEng-expressing mice were characterized by multiple abnormalities, particularly in the superficial vascular plexus.
Gene_expression (expressing) of sEng associated with reprotox - general 3
5) Confidence 0.63 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.27 Pain Relevance 0
Acetylcholine (ACh), an endothelium-dependent vasodilator, led to increased blood flow in control mice but not in sEng-expressing mice, indicating impaired endothelial vasoactive capacity (Figure 2E).


Neg (not) Gene_expression (expressing) of sEng in blood
6) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0 Pain Relevance 0.04
signaling was inhibited by systemic expression of soluble endoglin (sEng) and inhibition was demonstrated by reduced phospho-smad2 in the adult retina.
Gene_expression (expression) of endoglin in retina
7) Confidence 0.56 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2659748 Disease Relevance 0.09 Pain Relevance 0
Quantification of the collagen and dextran-positive vessels in the inner layers of the retina confirmed a significant (approx. 25%) reduction in vascular perfusion in sEng-expressing mice (Figure 2D).
Gene_expression (expressing) of sEng in vessels
8) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.07 Pain Relevance 0
Though there was no change in the density of type IV collagen-positive vessels in the retinas of sEng-expressing mice compared to control mice, numerous of the type IV collagen-positive were FITC-dextran negative (Figure 2C), indicating non-perfusion.
Gene_expression (expressing) of sEng in retinas
9) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.08 Pain Relevance 0
The staining intensity of pp-smad2 was reproducibly reduced in Ad-sEng-expressing mice as compared to control mice (Figure 1C).
Gene_expression (expressing) of sEng
10) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.17 Pain Relevance 0
Abnormal perfusion was apparent in retinal flat-mount preparations from sEng-expressing mice (Figure 2A), and co-staining for type IV collagen, a component of the capillary basement membrane, confirmed a lack of perfusion in some vessels of sEng expressing mice (Figure 2B).
Gene_expression (expressing) of sEng in capillary
11) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.15 Pain Relevance 0
Our studies demonstrate perfusion abnormalities in sEng-expressing mice.
Gene_expression (expressing) of sEng associated with congenital anomalies
12) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.41 Pain Relevance 0
Immunoprecipitation of occludin, followed by western blotting for zo-1, revealed a decrease in association between these two proteins in sEng-expressing mice (Figure 3D).
Gene_expression (expressing) of sEng
13) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0 Pain Relevance 0.03
Western blot analysis for pp-smad2 on whole retina lysates indicated a marked reduction of smad2 phosphorylation in Ad-sEng mice compared to the control after seven days (Figure 1E; Figure 1F quantification), demonstrating that systemic expression of sEng effectively neutralizes TGF-?
Gene_expression (expression) of sEng in retina
14) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.20 Pain Relevance 0
Whereas vessels in Ad-null control mice were well-defined and did not exhibit evidence of fluorescein leakage, vessels of sEng-expressing mice appeared more diffuse due to a more rapid leakage of the dye (Figure 3A).
Gene_expression (expressing) of sEng in vessels
15) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0 Pain Relevance 0.05
In parallel experiments, extravasated Evans blue was quantified and confirmed a breakdown of the blood-retinal barrier in sEng-expressing mice (Figure 3B).
Gene_expression (expressing) of sEng in blood
16) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0 Pain Relevance 0.04
signaling was inhibited by systemic expression of soluble endoglin (sEng) and inhibition was demonstrated by reduced phospho-smad2 in the adult retina.
Gene_expression (expression) of sEng in retina
17) Confidence 0.49 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2659748 Disease Relevance 0.09 Pain Relevance 0
Abnormal perfusion was apparent in retinal flat-mount preparations from sEng-expressing mice (Figure 2A), and co-staining for type IV collagen, a component of the capillary basement membrane, confirmed a lack of perfusion in some vessels of sEng expressing mice (Figure 2B).
Neg (lack) Gene_expression (expressing) of sEng in vessels
18) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.09 Pain Relevance 0
ENG (CD105), a surface marker used to define a bone marrow stromal cell population, capable of multilineage differentiation,[24] was down expressed in treated PB-hMSCs, with respect to control, at seven days, indicating the differentiation effect of this biomaterial on stem cells.
Gene_expression (expressed) of CD105 in stem cells
19) Confidence 0.45 Published 2010 Journal Journal of Indian Society of Periodontology Section Body Doc Link PMC2933523 Disease Relevance 0.48 Pain Relevance 0
We have quantified levels of CD105, its ligand TGFbeta and receptor-ligand complexes in sera from healthy individuals (n=31), patients with triple vessel disease documented by coronary angiography (TVD; n=36) and patients with chest pain and a positive exercise electrocardiogram but with normal coronary angiogram (NCA; n=30).
Gene_expression (levels) of CD105 in chest associated with angina and disease
20) Confidence 0.40 Published 2000 Journal Atherosclerosis Section Abstract Doc Link 10996361 Disease Relevance 0.26 Pain Relevance 0.09

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