INT90939

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Context Info
Confidence 0.64
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 4.62
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Eng) cell motility (Eng) cell adhesion (Eng)
nucleus (Eng) cytoplasm (Eng)
Anatomy Link Frequency
vessels 1
fibroblast 1
ganglion cells 1
stem cell 1
neural 1
Eng (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 3 99.52 Very High Very High Very High
Pain 4 96.76 Very High Very High Very High
Inflammatory mediators 3 96.52 Very High Very High Very High
Angina 2 89.32 High High
Central nervous system 1 37.56 Quite Low
anesthesia 6 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibromyalgia 7 100.00 Very High Very High Very High
Sickle Cell Anemia 12 99.84 Very High Very High Very High
Malaria 20 98.96 Very High Very High Very High
Apoptosis 87 98.52 Very High Very High Very High
Cerebral Malaria 46 98.00 Very High Very High Very High
Cancer 6 97.96 Very High Very High Very High
Ganglion Cysts 39 97.28 Very High Very High Very High
Immunotherapy Of Cancer 3 96.36 Very High Very High Very High
INFLAMMATION 3 96.12 Very High Very High Very High
Osteoporosis 42 89.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, an increase of the soluble Endoglin has been shown in severe malaria [16].
Positive_regulation (increase) of Endoglin associated with malaria
1) Confidence 0.64 Published 2010 Journal Malar J Section Body Doc Link PMC2898786 Disease Relevance 1.18 Pain Relevance 0.13
Consistent with these findings, increased endoglin is a defining feature of proliferating vessels in tumors and is a current target for anti-cancer treatments (http://www.clinicaltrials.gov/ct2/show/NCT00582985?
Positive_regulation (increased) of endoglin in vessels associated with cancer and immunotherapy of cancer
2) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.30 Pain Relevance 0
High levels of circulating sEng also led to significant neural cell apoptosis, particularly of the ganglion cells and neural cells of the INL.
Positive_regulation (levels) of sEng in ganglion cells associated with ganglion cysts and apoptosis
3) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.48 Pain Relevance 0.05
CD105 levels in TVD patients were also diminished but elevated in NCA patients.
Positive_regulation (elevated) of CD105
4) Confidence 0.36 Published 2000 Journal Atherosclerosis Section Abstract Doc Link 10996361 Disease Relevance 0.25 Pain Relevance 0.09
TGFbeta3 levels were similar in the three groups, but elevated CD105/TGFbeta3 levels were noted in patients with NCA compared with those with TVD and healthy individuals (P< or =0.02).
Positive_regulation (elevated) of CD105
5) Confidence 0.36 Published 2000 Journal Atherosclerosis Section Abstract Doc Link 10996361 Disease Relevance 0.41 Pain Relevance 0.08
The cell surfaces were positive for mesenchymal stem cell markers, CD105, CD90, and CD73, and negative for the marker of the hematopoietic origin, CD34 [Figure 1].
Positive_regulation (positive) of CD105 in stem cell
6) Confidence 0.27 Published 2010 Journal Journal of Indian Society of Periodontology Section Body Doc Link PMC2933523 Disease Relevance 0.09 Pain Relevance 0
High levels of circulating sEng also led to significant neural cell apoptosis, particularly of the ganglion cells and neural cells of the INL.
Positive_regulation (levels) of sEng in neural associated with ganglion cysts and apoptosis
7) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.48 Pain Relevance 0.05
Isolated PB-hMSCs showed fibroblast-like morphology and were positive for MSC surface molecules (CD90, CD105, CD73) and negative for markers of hematopoietic progenitors (CD34).
Positive_regulation (positive) of CD105 in fibroblast
8) Confidence 0.12 Published 2010 Journal Journal of Indian Society of Periodontology Section Body Doc Link PMC2933523 Disease Relevance 0.18 Pain Relevance 0
Both sFlt-1 (p = 0.002) and sEng (p = 0.004) were elevated in patients during clinically asymptomatic SCD with no further increment during painful crisis.
Positive_regulation (elevated) of sEng associated with sickle cell anemia and pain
9) Confidence 0.02 Published 2008 Journal Acta Haematol. Section Abstract Doc Link 19039203 Disease Relevance 0.62 Pain Relevance 0.10
Increased serum levels of anti-angiogenic factors soluble fms-like tyrosine kinase and soluble endoglin in sickle cell disease.
Positive_regulation (Increased) of soluble endoglin associated with sickle cell anemia and fibromyalgia
10) Confidence 0.02 Published 2008 Journal Acta Haematol. Section Title Doc Link 19039203 Disease Relevance 0.62 Pain Relevance 0.07

General Comments

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