INT9094

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Context Info
Confidence 0.77
First Reported 1981
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 277
Total Number 278
Disease Relevance 143.42
Pain Relevance 38.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL7A1) cell adhesion (COL7A1)
Anatomy Link Frequency
fibroblasts 29
extracellular matrix 11
cartilage 9
chondrocytes 9
skin 8
COL7A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 579 100.00 Very High Very High Very High
Nerve growth factor 2 100.00 Very High Very High Very High
Osteoarthritis 926 99.92 Very High Very High Very High
fibrosis 467 99.90 Very High Very High Very High
Snapping jaw 17 99.84 Very High Very High Very High
Inflammation 1117 99.72 Very High Very High Very High
metalloproteinase 201 99.70 Very High Very High Very High
aspirin 90 99.50 Very High Very High Very High
Inflammatory mediators 92 99.48 Very High Very High Very High
cINOD 319 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 789 100.00 Very High Very High Very High
Apoptosis 464 100.00 Very High Very High Very High
Adhesions 152 100.00 Very High Very High Very High
Hyalinosis 2 100.00 Very High Very High Very High
Injury 1910 99.98 Very High Very High Very High
Osteoarthritis 717 99.92 Very High Very High Very High
Fibrosis 302 99.90 Very High Very High Very High
Keloid Scars 207 99.86 Very High Very High Very High
Knee Osteoarthritis 104 99.84 Very High Very High Very High
Temporomandibular Joint Syndrome 17 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At 2 weeks the catheters were removed, and the amount of hydroxyproline was determined as an index of new collagen synthesis and deposition.
Gene_expression (synthesis) of collagen
1) Confidence 0.77 Published 1990 Journal Surgery Section Abstract Doc Link 2382229 Disease Relevance 0.22 Pain Relevance 0.07
Our studies show that the glycation of human corneal and scleral collagen produces increases in the collagen intermolecular spacing-these increases are similar to those we previously reported on the ageing of collagen in these tissues.
Gene_expression (produces) of collagen associated with aging
2) Confidence 0.77 Published 1996 Journal Age Ageing Section Abstract Doc Link 8831872 Disease Relevance 0.73 Pain Relevance 0.11
Osteogenesis imperfecta (OI) is a rare congenital disorder of type capital I, Ukrainian collagen production that results in brittle bones and affects body systems containing collagen.
Gene_expression (production) of collagen in body associated with osteogenesis imperfecta and "congenital, hereditary, and neonatal diseases and abnormalities"
3) Confidence 0.77 Published 2008 Journal Knee Section Abstract Doc Link 18757201 Disease Relevance 0.86 Pain Relevance 0.16
Attention has been focused on myocyte alterations due to the remodelling process, but the myocardial wall also contains fibroblasts, which produce collagen and elastin fibers, and endothelial and smooth muscle cells which are the main constituents of the vascular wall.
Gene_expression (produce) of collagen in smooth muscle cells
4) Confidence 0.77 Published 1994 Journal Cardiologia Section Abstract Doc Link 7634267 Disease Relevance 0.24 Pain Relevance 0
Ascorbate is essential for collagen production, and vitamin C deficiency will result in defective connective tissue, including reductions in collagen synthesis and structural stability.
Gene_expression (production) of collagen in connective tissue
5) Confidence 0.77 Published 2010 Journal Med. Hypotheses Section Abstract Doc Link 19932568 Disease Relevance 0.99 Pain Relevance 0.09
Osteogenesis imperfecta (OI) is a group of hereditary disorders most often due to an anomaly of collagen biosynthesis.
Gene_expression (biosynthesis) of collagen associated with osteogenesis imperfecta
6) Confidence 0.77 Published 2007 Journal Rev. Neurol. (Paris) Section Abstract Doc Link 17878811 Disease Relevance 0.82 Pain Relevance 0.08
Fibrocytes synthesizing new collagen or acquiring myofibroblast markers have been detected in human hypertrophic scars, in the skin of patients affected by nephrogenic systemic fibrosis, in human atherosclerotic lesions, and in pulmonary diseases characterized by repeated cycles of inflammation and repair, like asthma.
Gene_expression (synthesizing) of collagen in skin associated with asthma, nephrogenic fibrosing dermopathy, fibrosis, pulmonary disease, inflammation, atherosclerosis and keloid scars
7) Confidence 0.77 Published 2007 Journal Lab. Invest. Section Abstract Doc Link 17607298 Disease Relevance 1.52 Pain Relevance 0.20
Ascorbate is essential for collagen production, and vitamin C deficiency will result in defective connective tissue, including reductions in collagen synthesis and structural stability.
Gene_expression (synthesis) of collagen in connective tissue
8) Confidence 0.77 Published 2010 Journal Med. Hypotheses Section Abstract Doc Link 19932568 Disease Relevance 1.03 Pain Relevance 0.10
After training, collagen synthesis was increased in the initially injured tendon (n=6; carboxyterminal propeptide of type I collagen (PICP): pre 3.9+/-2.5 microg/L to post 19.7+/-5.4 microg/L, P<0.05).
Gene_expression (synthesis) of collagen in tendon
9) Confidence 0.76 Published 2007 Journal Scand J Med Sci Sports Section Abstract Doc Link 16787448 Disease Relevance 0.38 Pain Relevance 0.07
The collagen synthesis was unchanged in healthy tendons in response to training (n=6; PICP: pre 8.3+/-5.2 microg/L to post 11.5+/-5.0 microg/L, P>0.05).
Gene_expression (synthesis) of collagen in tendons
10) Confidence 0.76 Published 2007 Journal Scand J Med Sci Sports Section Abstract Doc Link 16787448 Disease Relevance 0.41 Pain Relevance 0.12
Since its aminoterminal propeptide (PIIIP) is formed in equimolar proportions to collagen, serum measurements of this fragment can provide an index of collagen synthesis, also during acromegaly [21].
Gene_expression (synthesis) of collagen associated with acromegaly
11) Confidence 0.75 Published 2002 Journal BMC Public Health Section Body Doc Link PMC128828 Disease Relevance 0.58 Pain Relevance 0.05
It showed a statistically significant influence of burst TENS on new collagen production, maturation of newly formed collagen and organisation of collagen.
Gene_expression (production) of collagen
12) Confidence 0.72 Published 2005 Journal Acta Orthop Belg Section Abstract Doc Link 16035709 Disease Relevance 0.07 Pain Relevance 0.30
Thus measurement of collagen type specific propeptides in suction blisters can be used as an estimate of collagen synthesis in vivo, avoiding both local anesthesia and skin biopsing.
Gene_expression (synthesis) of collagen in skin associated with anesthesia and blister
13) Confidence 0.68 Published 1992 Journal J. Invest. Dermatol. Section Abstract Doc Link 1732386 Disease Relevance 0.56 Pain Relevance 0.10
Collagen is synthesized as procollagen and large extra domains known as propeptides are cleaved off enzymatically.
Gene_expression (synthesized) of Collagen
14) Confidence 0.68 Published 1992 Journal J. Invest. Dermatol. Section Abstract Doc Link 1732386 Disease Relevance 0.48 Pain Relevance 0
A new method to measure type I and III collagen synthesis in human skin in vivo: demonstration of decreased collagen synthesis after topical glucocorticoid treatment.
Gene_expression (synthesis) of collagen in skin
15) Confidence 0.68 Published 1992 Journal J. Invest. Dermatol. Section Title Doc Link 1732386 Disease Relevance 0.57 Pain Relevance 0
A new method to measure type I and III collagen synthesis in human skin in vivo: demonstration of decreased collagen synthesis after topical glucocorticoid treatment.
Gene_expression (synthesis) of collagen in skin
16) Confidence 0.68 Published 1992 Journal J. Invest. Dermatol. Section Title Doc Link 1732386 Disease Relevance 0.55 Pain Relevance 0
Neither ASA nor Etodolac modified type-II collagen production.
Gene_expression (production) of collagen associated with aspirin
17) Confidence 0.68 Published 1992 Journal Agents Actions Section Abstract Doc Link 1388320 Disease Relevance 0.08 Pain Relevance 0.49
In this study the effect of oral arginine supplementation on human collagen synthesis and T-cell function was studied in 36 healthy, nonsmoking human volunteers.
Gene_expression (synthesis) of collagen in T-cell
18) Confidence 0.68 Published 1990 Journal Surgery Section Abstract Doc Link 2382229 Disease Relevance 0.17 Pain Relevance 0.09
Abnormal platelet aggregation was observed during platelet viability testing, in which adenosine diphosphate, epinephrine, ristocetin, arachidonic acid, and collagen were used as agonists.
Gene_expression (used) of collagen in platelet
19) Confidence 0.67 Published 1992 Journal Ann Pharmacother Section Body Doc Link 1482806 Disease Relevance 0 Pain Relevance 0
The collagen fiber organization in the anterior band (AB), intermediate zone (IZ) and posterior band (PB) of the disk of the human jaw joint disk and in its attachments was studied under the polarizing microscope.
Gene_expression (organization) of collagen in anterior
20) Confidence 0.67 Published 2006 Journal Cells Tissues Organs (Print) Section Abstract Doc Link 16914922 Disease Relevance 0.07 Pain Relevance 0.07

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