INT90942

Context Info Confidence 0.61 First Reported 2000 Last Reported 2010 Negated 0 Speculated 5 Reported most in Abstract Documents 31 Total Number 35 Disease Relevance 16.61 Pain Relevance 13.69

transport (P2rx1) plasma membrane (P2rx1) protein complex (P2rx1)

Anatomy Link Frequency bladder 3 C8-B4 3 neurons 2 skin 2 spinal cord 1 P2rx1 (Mus musculus)

Pain Link Frequency Relevance Heat agonist 92 100.00 antagonist 88 100.00 nociceptor 34 100.00 adenocard 28 100.00 cytokine 99 99.96 Analgesic 11 99.80 Calcitonin gene-related peptide 11 99.72 Cancer pain 6 99.64 Root ganglion neuron 2 99.16 Migraine 4 98.78

Disease Link Frequency Relevance Heat Targeted Disruption 116 100.00 Nociception 64 99.84 Cancer Pain 6 99.64 Ganglion Cysts 224 99.44 Headache 16 98.78 Neuropathic Pain 94 98.60 Hyperalgesia 14 98.48 Skin Cancer 8 98.00 Pain 106 97.80 Diabetic Neuropathy 4 97.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

P2X receptor-mediated modulation of sensory transmission to the spinal cord dorsal horn.

Regulation (modulation) of P2X in spinal cord dorsal horn associated with dorsal horn and spinal cord

1) Confidence 0.61 Published 2003 Journal Neuroscientist Section Title Doc Link 14580121 Disease Relevance 0.16 Pain Relevance 0.36

Modulation of P2X receptors in dorsal root ganglion neurons of streptozotocin-induced diabetic neuropathy.

Regulation (Modulation) of P2X in dorsal root ganglion associated with ganglion cysts, nociceptor, diabetic neuropathy and root ganglion neuron

2) Confidence 0.55 Published 2009 Journal Neurosci. Lett. Section Title Doc Link 19383439 Disease Relevance 0.93 Pain Relevance 1.21

Effects of agonists and antagonists of P2X-purinoceptors on the regulation of the development of allodynia were examined in mice; the drugs were administered intrathecally to the spinal cord.

Regulation (Effects) of P2X in spinal cord associated with allodynia, antagonist, agonist and spinal cord

3) Confidence 0.44 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10996441 Disease Relevance 0.44 Pain Relevance 0.78

The major migraine mediator calcitonin gene-related peptide (CGRP) is known to sensitize P2X(3) receptors to increase impulse flow to brainstem trigeminal nuclei.

Regulation (sensitize) of P2X in brainstem associated with medulla, migraine and calcitonin gene-related peptide

4) Confidence 0.44 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18460469 Disease Relevance 0.54 Pain Relevance 0.66

We study here the effect of the P2X(3) receptor antagonist, A-317491, on thermal hyperalgesia produced by the intratibial inoculation of NCTC 2472 fibrosarcoma cells to C3H/HeJ mice.

Regulation (effect) of P2X associated with fibrosarcoma, thermal hyperalgesia and antagonist

5) Confidence 0.44 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19765404 Disease Relevance 0.69 Pain Relevance 0.77

Although previous studies describe the up-regulation of purinergic P2X(3) receptors expressed at peripheral nociceptive fibers in experimental painful neoplastic processes, the analgesic efficacy of P2X(3) receptor antagonists has not been tested in these settings.

Regulation (regulation) of P2X associated with nociception, pain, antagonist, analgesic and neoplastic processes

6) Confidence 0.44 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19765404 Disease Relevance 0.62 Pain Relevance 0.60

In the present study, we examined the effect of P2X receptor antagonists, which are known to modulate the pain pathway, on mechanical hyperalgesia in streptozotocin (STZ)-induced diabetic mice.

Spec (examined) Regulation (effect) of P2X associated with pain, hyperalgesia, diabetes mellitus and antagonist

7) Confidence 0.40 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19383439 Disease Relevance 0.91 Pain Relevance 0.97

These data support the possibility that P2X receptors, particularly the P2X(3) subtype, could be targeted in the search for new, effective analgesics.

Regulation (targeted) of P2X associated with analgesic

8) Confidence 0.40 Published 2005 Journal Neuroscientist Section Abstract Doc Link 16061521 Disease Relevance 0.48 Pain Relevance 0.46

These results suggest that ATP and P2X, especially P2X(3), receptors are involved in skin cancer pain, due to the increased release of ATP and increased expression of P2X(3) receptors in the sensory neurons.

Regulation (involved) of P2X in skin associated with cancer pain

9) Confidence 0.39 Published 2010 Journal Eur. J. Neurosci. Section Abstract Doc Link 20525075 Disease Relevance 1.15 Pain Relevance 0.42

These results suggest that ATP and P2X, especially P2X(3), receptors are involved in skin cancer pain, due to the increased release of ATP and increased expression of P2X(3) receptors in the sensory neurons.

Regulation (involved) of P2X in skin associated with cancer pain

10) Confidence 0.39 Published 2010 Journal Eur. J. Neurosci. Section Abstract Doc Link 20525075 Disease Relevance 1.14 Pain Relevance 0.42

The present study explores the possible involvement of a purinergic mechanism in mechanosensory transduction in the bladder using P2X(3) receptor knock-out (P2X(3)-/-) and wild-type control (P2X(3)+/+) mice.

Regulation (using) of P2X in bladder associated with targeted disruption

11) Confidence 0.39 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11466438 Disease Relevance 0.17 Pain Relevance 0.04

The present study explores the possible involvement of a purinergic mechanism in mechanosensory transduction in the bladder using P2X(3) receptor knock-out (P2X(3)-/-) and wild-type control (P2X(3)+/+) mice.

Regulation (using) of P2X in bladder associated with targeted disruption

12) Confidence 0.39 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11466438 Disease Relevance 0.17 Pain Relevance 0.04

To investigate the effect of P2X receptor subunit gene deletion on neurogenic responses, nicotine was used to active myenteric neurons.

Spec (investigate) Regulation (effect) of P2X receptor in neurons associated with nicotine

13) Confidence 0.35 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2858605 Disease Relevance 0.22 Pain Relevance 0.42

As discussed above, it is possible that P2X receptors normally contribute to MMC propagation but in P2X subunit KO mice there are compensatory changes in receptor expression that maintain normal MMC propagation.

Spec (possible) Regulation (contribute) of P2X associated with targeted disruption

14) Confidence 0.35 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2858605 Disease Relevance 0.46 Pain Relevance 0.04

Using gene-silencing, pharmacological and electrophysiological approaches, recent studies have revealed roles for P2X(2), P2X(3), P2X(4) and P2X(7) receptors in nociceptive signalling.

Regulation (roles) of P2X associated with nociception

15) Confidence 0.27 Published 2006 Journal Expert Opin Ther Pat Section Abstract Doc Link 20144056 Disease Relevance 0.45 Pain Relevance 0.27

Using gene-silencing, pharmacological and electrophysiological approaches, recent studies have revealed roles for P2X(2), P2X(3), P2X(4) and P2X(7) receptors in nociceptive signalling.

Regulation (roles) of P2X associated with nociception

16) Confidence 0.27 Published 2006 Journal Expert Opin Ther Pat Section Abstract Doc Link 20144056 Disease Relevance 0.44 Pain Relevance 0.27

Using gene-silencing, pharmacological and electrophysiological approaches, recent studies have revealed roles for P2X(2), P2X(3), P2X(4) and P2X(7) receptors in nociceptive signalling.

Regulation (roles) of P2X associated with nociception

17) Confidence 0.27 Published 2006 Journal Expert Opin Ther Pat Section Abstract Doc Link 20144056 Disease Relevance 0.44 Pain Relevance 0.26

We hypothesise that the P2X(7) receptor, via regulation of mature IL-1beta production, plays a common upstream transductional role in the development of pain of neuropathic and inflammatory origin.

Regulation (regulation) of P2X associated with pain, inflammation and neuropathic pain

18) Confidence 0.26 Published 2005 Journal Pain Section Abstract Doc Link 15777864 Disease Relevance 1.05 Pain Relevance 0.58

In this study, we describe the role of exogenous and endogenous adenosine and exogenous P2X(1) and P2Y(1) agonists for spontaneous splenic IL-6 secretion from spleen slices.

Regulation (role) of P2X in spleen associated with adenocard and agonist

19) Confidence 0.26 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 11960643 Disease Relevance 0 Pain Relevance 0.60

Using gene-silencing, pharmacological and electrophysiological approaches, recent studies have revealed roles for P2X(2), P2X(3), P2X(4) and P2X(7) receptors in nociceptive signalling.

Regulation (roles) of P2X associated with nociception

20) Confidence 0.24 Published 2006 Journal Expert Opin Ther Pat Section Abstract Doc Link 20144056 Disease Relevance 0.45 Pain Relevance 0.27

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