INT90942

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Context Info
Confidence 0.61
First Reported 2000
Last Reported 2010
Negated 0
Speculated 5
Reported most in Abstract
Documents 31
Total Number 35
Disease Relevance 16.61
Pain Relevance 13.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (P2rx1) plasma membrane (P2rx1) protein complex (P2rx1)
Anatomy Link Frequency
bladder 3
C8-B4 3
neurons 2
skin 2
spinal cord 1
P2rx1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 92 100.00 Very High Very High Very High
antagonist 88 100.00 Very High Very High Very High
nociceptor 34 100.00 Very High Very High Very High
adenocard 28 100.00 Very High Very High Very High
cytokine 99 99.96 Very High Very High Very High
Analgesic 11 99.80 Very High Very High Very High
Calcitonin gene-related peptide 11 99.72 Very High Very High Very High
Cancer pain 6 99.64 Very High Very High Very High
Root ganglion neuron 2 99.16 Very High Very High Very High
Migraine 4 98.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 116 100.00 Very High Very High Very High
Nociception 64 99.84 Very High Very High Very High
Cancer Pain 6 99.64 Very High Very High Very High
Ganglion Cysts 224 99.44 Very High Very High Very High
Headache 16 98.78 Very High Very High Very High
Neuropathic Pain 94 98.60 Very High Very High Very High
Hyperalgesia 14 98.48 Very High Very High Very High
Skin Cancer 8 98.00 Very High Very High Very High
Pain 106 97.80 Very High Very High Very High
Diabetic Neuropathy 4 97.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
P2X receptor-mediated modulation of sensory transmission to the spinal cord dorsal horn.
Regulation (modulation) of P2X in spinal cord dorsal horn associated with dorsal horn and spinal cord
1) Confidence 0.61 Published 2003 Journal Neuroscientist Section Title Doc Link 14580121 Disease Relevance 0.16 Pain Relevance 0.36
Modulation of P2X receptors in dorsal root ganglion neurons of streptozotocin-induced diabetic neuropathy.
Regulation (Modulation) of P2X in dorsal root ganglion associated with ganglion cysts, nociceptor, diabetic neuropathy and root ganglion neuron
2) Confidence 0.55 Published 2009 Journal Neurosci. Lett. Section Title Doc Link 19383439 Disease Relevance 0.93 Pain Relevance 1.21
Effects of agonists and antagonists of P2X-purinoceptors on the regulation of the development of allodynia were examined in mice; the drugs were administered intrathecally to the spinal cord.
Regulation (Effects) of P2X in spinal cord associated with allodynia, antagonist, agonist and spinal cord
3) Confidence 0.44 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10996441 Disease Relevance 0.44 Pain Relevance 0.78
The major migraine mediator calcitonin gene-related peptide (CGRP) is known to sensitize P2X(3) receptors to increase impulse flow to brainstem trigeminal nuclei.
Regulation (sensitize) of P2X in brainstem associated with medulla, migraine and calcitonin gene-related peptide
4) Confidence 0.44 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18460469 Disease Relevance 0.54 Pain Relevance 0.66
We study here the effect of the P2X(3) receptor antagonist, A-317491, on thermal hyperalgesia produced by the intratibial inoculation of NCTC 2472 fibrosarcoma cells to C3H/HeJ mice.
Regulation (effect) of P2X associated with fibrosarcoma, thermal hyperalgesia and antagonist
5) Confidence 0.44 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19765404 Disease Relevance 0.69 Pain Relevance 0.77
Although previous studies describe the up-regulation of purinergic P2X(3) receptors expressed at peripheral nociceptive fibers in experimental painful neoplastic processes, the analgesic efficacy of P2X(3) receptor antagonists has not been tested in these settings.
Regulation (regulation) of P2X associated with nociception, pain, antagonist, analgesic and neoplastic processes
6) Confidence 0.44 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19765404 Disease Relevance 0.62 Pain Relevance 0.60
In the present study, we examined the effect of P2X receptor antagonists, which are known to modulate the pain pathway, on mechanical hyperalgesia in streptozotocin (STZ)-induced diabetic mice.
Spec (examined) Regulation (effect) of P2X associated with pain, hyperalgesia, diabetes mellitus and antagonist
7) Confidence 0.40 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19383439 Disease Relevance 0.91 Pain Relevance 0.97
These data support the possibility that P2X receptors, particularly the P2X(3) subtype, could be targeted in the search for new, effective analgesics.
Regulation (targeted) of P2X associated with analgesic
8) Confidence 0.40 Published 2005 Journal Neuroscientist Section Abstract Doc Link 16061521 Disease Relevance 0.48 Pain Relevance 0.46
These results suggest that ATP and P2X, especially P2X(3), receptors are involved in skin cancer pain, due to the increased release of ATP and increased expression of P2X(3) receptors in the sensory neurons.
Regulation (involved) of P2X in skin associated with cancer pain
9) Confidence 0.39 Published 2010 Journal Eur. J. Neurosci. Section Abstract Doc Link 20525075 Disease Relevance 1.15 Pain Relevance 0.42
These results suggest that ATP and P2X, especially P2X(3), receptors are involved in skin cancer pain, due to the increased release of ATP and increased expression of P2X(3) receptors in the sensory neurons.
Regulation (involved) of P2X in skin associated with cancer pain
10) Confidence 0.39 Published 2010 Journal Eur. J. Neurosci. Section Abstract Doc Link 20525075 Disease Relevance 1.14 Pain Relevance 0.42
The present study explores the possible involvement of a purinergic mechanism in mechanosensory transduction in the bladder using P2X(3) receptor knock-out (P2X(3)-/-) and wild-type control (P2X(3)+/+) mice.
Regulation (using) of P2X in bladder associated with targeted disruption
11) Confidence 0.39 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11466438 Disease Relevance 0.17 Pain Relevance 0.04
The present study explores the possible involvement of a purinergic mechanism in mechanosensory transduction in the bladder using P2X(3) receptor knock-out (P2X(3)-/-) and wild-type control (P2X(3)+/+) mice.
Regulation (using) of P2X in bladder associated with targeted disruption
12) Confidence 0.39 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11466438 Disease Relevance 0.17 Pain Relevance 0.04
To investigate the effect of P2X receptor subunit gene deletion on neurogenic responses, nicotine was used to active myenteric neurons.
Spec (investigate) Regulation (effect) of P2X receptor in neurons associated with nicotine
13) Confidence 0.35 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2858605 Disease Relevance 0.22 Pain Relevance 0.42
As discussed above, it is possible that P2X receptors normally contribute to MMC propagation but in P2X subunit KO mice there are compensatory changes in receptor expression that maintain normal MMC propagation.
Spec (possible) Regulation (contribute) of P2X associated with targeted disruption
14) Confidence 0.35 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2858605 Disease Relevance 0.46 Pain Relevance 0.04
Using gene-silencing, pharmacological and electrophysiological approaches, recent studies have revealed roles for P2X(2), P2X(3), P2X(4) and P2X(7) receptors in nociceptive signalling.
Regulation (roles) of P2X associated with nociception
15) Confidence 0.27 Published 2006 Journal Expert Opin Ther Pat Section Abstract Doc Link 20144056 Disease Relevance 0.45 Pain Relevance 0.27
Using gene-silencing, pharmacological and electrophysiological approaches, recent studies have revealed roles for P2X(2), P2X(3), P2X(4) and P2X(7) receptors in nociceptive signalling.
Regulation (roles) of P2X associated with nociception
16) Confidence 0.27 Published 2006 Journal Expert Opin Ther Pat Section Abstract Doc Link 20144056 Disease Relevance 0.44 Pain Relevance 0.27
Using gene-silencing, pharmacological and electrophysiological approaches, recent studies have revealed roles for P2X(2), P2X(3), P2X(4) and P2X(7) receptors in nociceptive signalling.
Regulation (roles) of P2X associated with nociception
17) Confidence 0.27 Published 2006 Journal Expert Opin Ther Pat Section Abstract Doc Link 20144056 Disease Relevance 0.44 Pain Relevance 0.26
We hypothesise that the P2X(7) receptor, via regulation of mature IL-1beta production, plays a common upstream transductional role in the development of pain of neuropathic and inflammatory origin.
Regulation (regulation) of P2X associated with pain, inflammation and neuropathic pain
18) Confidence 0.26 Published 2005 Journal Pain Section Abstract Doc Link 15777864 Disease Relevance 1.05 Pain Relevance 0.58
In this study, we describe the role of exogenous and endogenous adenosine and exogenous P2X(1) and P2Y(1) agonists for spontaneous splenic IL-6 secretion from spleen slices.
Regulation (role) of P2X in spleen associated with adenocard and agonist
19) Confidence 0.26 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 11960643 Disease Relevance 0 Pain Relevance 0.60
Using gene-silencing, pharmacological and electrophysiological approaches, recent studies have revealed roles for P2X(2), P2X(3), P2X(4) and P2X(7) receptors in nociceptive signalling.
Regulation (roles) of P2X associated with nociception
20) Confidence 0.24 Published 2006 Journal Expert Opin Ther Pat Section Abstract Doc Link 20144056 Disease Relevance 0.45 Pain Relevance 0.27

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