INT90943

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Context Info
Confidence 0.42
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 8.21
Pain Relevance 7.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (P2rx1) plasma membrane (P2rx1) protein complex (P2rx1)
Anatomy Link Frequency
nerve 2
urinary bladder 1
spinal cord 1
heart 1
P2rx1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 32 100.00 Very High Very High Very High
allodynia 8 100.00 Very High Very High Very High
agonist 37 99.92 Very High Very High Very High
Glutamate 100 99.18 Very High Very High Very High
adenocard 94 98.60 Very High Very High Very High
cytokine 5 98.28 Very High Very High Very High
Inflammation 17 97.72 Very High Very High Very High
Neuropathic pain 18 97.56 Very High Very High Very High
ischemia 40 97.48 Very High Very High Very High
dorsal root ganglion 19 97.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 37 100.00 Very High Very High Very High
Coronary Heart Disease 9 99.48 Very High Very High Very High
Nervous System Injury 9 98.88 Very High Very High Very High
Pressure And Volume Under Development 26 98.56 Very High Very High Very High
Arrhythmia Under Development 6 98.24 Very High Very High Very High
INFLAMMATION 13 97.72 Very High Very High Very High
Cv Unclassified Under Development 29 97.48 Very High Very High Very High
Ganglion Cysts 32 97.16 Very High Very High Very High
Coronary Artery Disease 6 95.72 Very High Very High Very High
Aging 1 94.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A-740003 (N-(1-{[(cyanoimino)(5-quinolinylamino) methyl] amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide) is a novel competitive antagonist of P2X(7) receptors (IC(50) values = 40 nM for human and 18 nM for rat) as measured by agonist-stimulated changes in intracellular calcium concentrations.
Negative_regulation (antagonist) of P2X associated with antagonist and agonist
1) Confidence 0.42 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16982702 Disease Relevance 0.44 Pain Relevance 0.59
Thus, P2X1 receptor antagonists inhibit, but do not abolish, the noncholinergic component of neurogenic contractions of guinea pig and mouse urinary bladder, indicating a second mode of action of neuronally released ATP.
Neg (not) Negative_regulation (abolish) of P2X1 in urinary bladder associated with antagonist
2) Confidence 0.41 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17251425 Disease Relevance 0 Pain Relevance 0.29
The average pressure-afferent response curve in mice deficient in both P2X(2) and P2X(3) subunits (n = 14) was not significantly different from that of the wild-type control preparations (n = 13).
Negative_regulation (deficient) of P2X
3) Confidence 0.37 Published 2009 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19220757 Disease Relevance 0.23 Pain Relevance 0.19
Genetic disruption of P2X(4) and P2X(7) signalling has been demonstrated to reduce inflammatory and neuropathic pain, suggesting that these two receptors might serve as integrators of neuroinflammation and pain.
Negative_regulation (disruption) of P2X associated with pain, inflammation and neuropathic pain
4) Confidence 0.26 Published 2006 Journal Expert Opin Ther Pat Section Abstract Doc Link 20144056 Disease Relevance 0.78 Pain Relevance 0.70
PPADS did not block glutamate-induced allodynia. alpha,beta-Methylene ATP (alpha, beta-meATP), an agonist of P2X receptor, elicited allodynia. alpha, beta-me ATP-induced allodynia was blocked by co-administration of alpha,beta-meATP with PPADS, MK 801 or N(omega)-nitro-L-arginine methyl ester (L-NAME).
Negative_regulation (blocked) of P2X receptor associated with glutamate, allodynia and agonist
5) Confidence 0.23 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10996441 Disease Relevance 0.72 Pain Relevance 1.21
Therefore, inhibition of these facilitatory P2X receptors might have therapeutic relevance in ischemic heart disease.
Negative_regulation (inhibition) of P2X in heart associated with coronary heart disease
6) Confidence 0.13 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072919 Disease Relevance 0.84 Pain Relevance 0.45
Another P2X receptor antagonist, trinitrophenyl adenosine triphosphate (TNP-ATP), was tested at the point of maximal effect of P2X blockade and it showed the same results (Figure 1A).
Negative_regulation (blockade) of P2X associated with adenocard and antagonist
7) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669296 Disease Relevance 0.21 Pain Relevance 0.13
The ATP-induced cPLA(2) activation was inhibited by a selective antagonist of P2X(3)R/P2X(2/3)R and by a selective inhibitor of cPLA(2).
Negative_regulation (antagonist) of P2X associated with antagonist
8) Confidence 0.10 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17725579 Disease Relevance 1.26 Pain Relevance 0.88
Pharmacological blockade of P2X(3)R/P2X(2/3)R reversed the nerve injury-induced cPLA(2) activation in DRG neurons.
Negative_regulation (blockade) of P2X in nerve associated with dorsal root ganglion and nervous system injury
9) Confidence 0.10 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17725579 Disease Relevance 1.34 Pain Relevance 0.99
An analogous mechanism could play a role in the spinal cord during the sensitization process leading to various forms of sensory neuropathy; therefore, attenuation of increased glutamate release from the central terminals of primary sensory neurons by the inhibition of P2X receptors is a potential pathway which could be utilized in neuropathic pain.
Negative_regulation (inhibition) of P2X in spinal cord associated with glutamate, neuropathic pain and spinal cord
10) Confidence 0.10 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072919 Disease Relevance 0.87 Pain Relevance 0.50
Since inhibitory P2Y receptors are frequently coexpressed on nerve terminals that are equipped with P2X receptors, activation of P2Y receptors could have a similar effect as the inhibition of P2X receptors.
Negative_regulation (inhibition) of P2X in nerve
11) Confidence 0.10 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072919 Disease Relevance 0.76 Pain Relevance 0.51
The swelling-inhibitory action of glutamate and ATP were blocked by suramin and the inhibitor of P2Y and distinct P2X receptors, PPADS (Fig. 1d).
Negative_regulation (inhibitor) of P2X associated with pressure and volume under development and glutamate
12) Confidence 0.07 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072913 Disease Relevance 0.58 Pain Relevance 0.77
TAKE HOME MESSAGE: P2X7R antagonists and other P2X inhibitors will probably be on the market for combating rheumatoid arthritis and other diseases.
Negative_regulation (inhibitors) of P2X
13) Confidence 0.02 Published 2010 Journal Expert Opin Ther Pat Section Body Doc Link 20205618 Disease Relevance 0 Pain Relevance 0

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