INT9095

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Context Info
Confidence 0.57
First Reported 1986
Last Reported 2010
Negated 7
Speculated 2
Reported most in Abstract
Documents 24
Total Number 27
Disease Relevance 10.55
Pain Relevance 4.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL7A1) cell adhesion (COL7A1)
Anatomy Link Frequency
fibroblasts 8
cartilage 6
articular cartilage 3
tendons 2
ECM 2
COL7A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 14 99.72 Very High Very High Very High
cINOD 82 99.44 Very High Very High Very High
cytokine 54 99.36 Very High Very High Very High
Inflammatory response 19 99.00 Very High Very High Very High
Inflammation 145 98.98 Very High Very High Very High
rheumatoid arthritis 94 97.44 Very High Very High Very High
Chronic pancreatitis 3 95.20 Very High Very High Very High
fibrosis 9 92.84 High High
anesthesia 2 91.12 High High
corticosteroid 102 90.00 High High
Disease Link Frequency Relevance Heat
Injury 160 100.00 Very High Very High Very High
Apoptosis 99 100.00 Very High Very High Very High
INFLAMMATION 206 99.00 Very High Very High Very High
Keloid Scars 17 97.88 Very High Very High Very High
Rheumatoid Arthritis 96 97.44 Very High Very High Very High
Wound Healing 147 97.32 Very High Very High Very High
Chronic Disease 4 95.32 Very High Very High Very High
Pancreatitis 3 95.20 Very High Very High Very High
Adhesions 7 93.72 High High
Fibrosis 15 92.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It showed a statistically significant influence of burst TENS on new collagen production, maturation of newly formed collagen and organisation of collagen.
Regulation (influence) of Gene_expression (production) of collagen
1) Confidence 0.57 Published 2005 Journal Acta Orthop Belg Section Abstract Doc Link 16035709 Disease Relevance 0.07 Pain Relevance 0.30
In this study the effect of oral arginine supplementation on human collagen synthesis and T-cell function was studied in 36 healthy, nonsmoking human volunteers.
Regulation (effect) of Gene_expression (synthesis) of collagen in T-cell
2) Confidence 0.39 Published 1990 Journal Surgery Section Abstract Doc Link 2382229 Disease Relevance 0.17 Pain Relevance 0.09
Recent studies have shown the inhibitory effect of interferons on dermal fibroblast growth and/or collagen production.
Regulation (effect) of Gene_expression (production) of collagen in fibroblast
3) Confidence 0.34 Published 1996 Journal Int. J. Dermatol. Section Abstract Doc Link 8809610 Disease Relevance 0.65 Pain Relevance 0
Ascorbic acid stimulates type I collagen production more in FR control than in FR-CTS.
Regulation (control) of Gene_expression (production) of collagen
4) Confidence 0.33 Published 2000 Journal J. Occup. Environ. Med. Section Abstract Doc Link 10738704 Disease Relevance 0.25 Pain Relevance 0.25
The present study was designed to examine the effects of synthetic serine protease inhibitors (FOY-007 and FOY-305) on proliferation and collagen synthesis of hPFCs under cytokine stimulation.
Spec (examine) Regulation (effects) of Gene_expression (synthesis) of collagen associated with cytokine
5) Confidence 0.29 Published 2001 Journal Pancreas Section Abstract Doc Link 11291936 Disease Relevance 0.18 Pain Relevance 0.18
CONCLUSIONS: The inhibitory effect of acetylsalicylic acid on collagen biosynthesis in fibroblasts is coupled to the inhibition of prolidase phosphorylation (but not expression) and down-regulation of the intracellular signal transmitted by the b1-integrin receptor.


Regulation (effect) of Gene_expression (biosynthesis) of collagen in fibroblasts
6) Confidence 0.28 Published 2004 Journal Med. Sci. Monit. Section Body Doc Link 15173663 Disease Relevance 0 Pain Relevance 0
The collagen synthesis was unchanged in healthy tendons in response to training (n=6; PICP: pre 8.3+/-5.2 microg/L to post 11.5+/-5.0 microg/L, P>0.05).
Neg (unchanged) Regulation (unchanged) of Gene_expression (synthesis) of collagen in tendons
7) Confidence 0.26 Published 2007 Journal Scand J Med Sci Sports Section Abstract Doc Link 16787448 Disease Relevance 0.41 Pain Relevance 0.13
The action of 13 NSAIDs was compared in terms of their effect on cartilage GAG synthesis. 3 of these NSAIDs were also studied in terms of their effect on cartilage collagen synthesis.
Regulation (effect) of Gene_expression (synthesis) of collagen in cartilage associated with cinod
8) Confidence 0.25 Published 1999 Journal Z Rheumatol Section Abstract Doc Link 10441838 Disease Relevance 0.90 Pain Relevance 0.74
The mechanism of their action on collagen biosynthesis involves inactivation of prolidase, the enzyme that recovers proline from collagen degradation products for collagen re-synthesis.
Regulation (proline) of Gene_expression (synthesis) of collagen
9) Confidence 0.24 Published 2004 Journal Med. Sci. Monit. Section Abstract Doc Link 15173663 Disease Relevance 0.09 Pain Relevance 0.26
Neither ASA nor Etodolac modified type-II collagen production.
Neg (Neither) Regulation (modified) of Gene_expression (production) of collagen associated with aspirin
10) Confidence 0.24 Published 1992 Journal Agents Actions Section Abstract Doc Link 1388320 Disease Relevance 0.08 Pain Relevance 0.49
Effects of synthetic serine protease inhibitors on proliferation and collagen synthesis of human pancreatic periacinar fibroblast-like cells.
Regulation (Effects) of Gene_expression (synthesis) of collagen in fibroblast
11) Confidence 0.21 Published 2001 Journal Pancreas Section Title Doc Link 11291936 Disease Relevance 0.18 Pain Relevance 0.18
Both protease inhibitors demonstrated no effect on the proliferation and collagen synthesis of hPFCs when they were not stimulated by PDGF or TGF-beta1.
Neg (no) Regulation (effect) of Gene_expression (synthesis) of collagen
12) Confidence 0.21 Published 2001 Journal Pancreas Section Abstract Doc Link 11291936 Disease Relevance 0.12 Pain Relevance 0.13
Therapeutic levels of piroxicam has no effect on cartilage glycosaminoglycan (GAG), collagen or noncollagen protein synthesis by porcine weight bearing articular cartilage explants.
Neg (no) Regulation (effect) of Gene_expression (synthesis) of collagen in articular cartilage
13) Confidence 0.20 Published 1986 Journal J. Rheumatol. Section Abstract Doc Link 3560088 Disease Relevance 0.17 Pain Relevance 0.25
We found that PIINP levels are significantly higher in NSAID users, this suggests an up-regulation of type III collagen synthesis.
Regulation (regulation) of Gene_expression (synthesis) of collagen associated with cinod
14) Confidence 0.18 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993941 Disease Relevance 0.29 Pain Relevance 0.19
Studies on bleomycin and doxorubicin demonstrate negative effects on wound tensile strength and collagen synthesis that can be limited by avoiding treatment within 1 week of surgical intervention.
Regulation (effects) of Gene_expression (synthesis) of collagen associated with injury
15) Confidence 0.13 Published 2008 Journal Eplasty Section Body Doc Link PMC2206003 Disease Relevance 1.02 Pain Relevance 0.17
Collagen is indeed a core component of the ECM, and undergoes remodeling that is dependent on both continued collagen synthesis and compensatory collagen degradation.
Regulation (dependent) of Gene_expression (synthesis) of collagen in ECM
16) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481293 Disease Relevance 0.96 Pain Relevance 0.12
Increased PIIINP levels suggest up-regulation of type III collagen synthesis.
Regulation (regulation) of Gene_expression (synthesis) of collagen
17) Confidence 0.13 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993941 Disease Relevance 0.24 Pain Relevance 0.18
An in vitro model for the investigation of chemically induced changes of collagen synthesis in human fibroblasts is presented.
Regulation (changes) of Gene_expression (synthesis) of collagen in fibroblasts
18) Confidence 0.08 Published 1988 Journal Biomed. Environ. Sci. Section Abstract Doc Link 3077263 Disease Relevance 0.40 Pain Relevance 0.22
Similar to the gene expression of collagen I, the presence of PLLA nanofibers had only little effect on the collagen III gene expression, while the presence of PLLA/Col-I blend nanofibers resulted in a 5 to 100 fold increase depending on the cells (p = 0.009).
Neg (little) Regulation (effect) of Gene_expression (expression) of collagen
19) Confidence 0.06 Published 2010 Journal Biomed Eng Online Section Body Doc Link PMC2837661 Disease Relevance 0 Pain Relevance 0
Furthermore, no meaningful influence on the gene expression of collagen I, collagen III and decorin could be observed, while the expression of collagen X increased during the course of cultivation.
Neg (no) Regulation (influence) of Gene_expression (expression) of collagen
20) Confidence 0.06 Published 2010 Journal Biomed Eng Online Section Abstract Doc Link PMC2837661 Disease Relevance 0.05 Pain Relevance 0

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