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Context Info
Confidence 0.43
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.75

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isomerase activity (PPIG) nucleoplasm (PPIG) small molecule metabolic process (CYP2C9)
endoplasmic reticulum (CYP2C9) cytoplasm (PPIG) protein folding (PPIG)
Anatomy Link Frequency
liver 1
PPIG (Homo sapiens)
CYP2C9 (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 9 98.72 Very High Very High Very High
sSRI 2 55.28 Quite High


Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data were corroborated with the examination of the effects of CYP-specific inhibitors quinidine (CYP2D6), sulfaphenazole (CYP2C9), and ketoconazole (CYP3A4) on fluoxetine N-demethylation in pooled human liver microsomes.
CYP Regulation (effects) of CYP2C9 in liver associated with fluoxetine
1) Confidence 0.43 Published 2000 Journal Drug Metab. Dispos. Section Abstract Doc Link 10997938 Disease Relevance 0 Pain Relevance 0.75

General Comments

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