INT90961

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Context Info
Confidence 0.42
First Reported 2000
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.60
Pain Relevance 5.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cnr1) aging (Cnr1) plasma membrane (Cnr1)
signal transducer activity (Cnr1)
Anatomy Link Frequency
interneurons 4
brain 2
caudate-putamen 2
neuromuscular junction 2
Cnr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Cannabinoid receptor 46 100.00 Very High Very High Very High
Cannabinoid 37 100.00 Very High Very High Very High
agonist 35 100.00 Very High Very High Very High
gABA 16 100.00 Very High Very High Very High
Glutamate 11 99.74 Very High Very High Very High
long-term potentiation 74 99.22 Very High Very High Very High
amygdala 131 99.14 Very High Very High Very High
qutenza 82 98.72 Very High Very High Very High
Action potential 4 98.16 Very High Very High Very High
GABAergic 23 98.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 10 98.76 Very High Very High Very High
Stress 18 47.32 Quite Low
Drug Dependence 2 46.88 Quite Low
Depression 9 30.40 Quite Low
Anxiety Disorder 11 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Body Weight 3 5.00 Very Low Very Low Very Low
Nociception 2 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 2 5.00 Very Low Very Low Very Low
Hyperalgesia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that activation of presynaptic CB1 receptors decreases Ca2+-dependent GABA release, and thereby reduces the power of hippocampal network oscillations.
Negative_regulation (decreases) of Positive_regulation (activation) of CB1 associated with gaba and cannabinoid receptor
1) Confidence 0.42 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 10998107 Disease Relevance 0.10 Pain Relevance 0.81
We conclude that activation of presynaptic CB1 receptors decreases Ca2+-dependent GABA release, and thereby reduces the power of hippocampal network oscillations.
Negative_regulation (reduces) of Positive_regulation (activation) of CB1 associated with gaba and cannabinoid receptor
2) Confidence 0.42 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 10998107 Disease Relevance 0.10 Pain Relevance 0.81
Action potential-driven IPSCs, evoked by pharmacological stimulation of a subset of interneurons, were also decreased by CB1 receptor activation.
Negative_regulation (decreased) of Positive_regulation (activation) of CB1 receptor in interneurons associated with action potential and cannabinoid receptor
3) Confidence 0.42 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 10998107 Disease Relevance 0.07 Pain Relevance 0.98
In contrast, the efficacy of CB1 receptor activation by the cannabinoid agonist WIN 55 212-2 was dramatically reduced in the caudate-putamen of MOR knockout animals.
Negative_regulation (reduced) of Positive_regulation (activation) of CB1 receptor in caudate-putamen associated with targeted disruption, cannabinoid and agonist
4) Confidence 0.42 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14622180 Disease Relevance 0.34 Pain Relevance 0.72
Extracellular field recordings and whole cell patch clamp in the alBNST rat brain slice preparation revealed that activation of CB1 strongly inhibits excitatory and inhibitory synaptic transmission.


Negative_regulation (inhibits) of Positive_regulation (activation) of CB1 in brain
5) Confidence 0.40 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2810340 Disease Relevance 0 Pain Relevance 0.20
Since we could not detect an involvement of GABAergic interneurons in the capsaicin-induced effect on LA-LTP, the release of glutamate seems to be reduced by CB1 activation (Fig. 8).
Negative_regulation (reduced) of Positive_regulation (activation) of CB1 in interneurons associated with glutamate, qutenza, gabaergic, long-term potentiation and amygdala
6) Confidence 0.33 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020947 Disease Relevance 0 Pain Relevance 1.31
Together these data show an inhibitory effect of CB1 activation on evoked acetylcholine release and the first evidence for the presence of a vanilloid receptor at the neuromuscular junction.
Negative_regulation (effect) of Positive_regulation (activation) of CB1 in neuromuscular junction
7) Confidence 0.28 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20176082 Disease Relevance 0 Pain Relevance 0.41

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