INT90962

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Context Info
Confidence 0.61
First Reported 2000
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 6
Total Number 10
Disease Relevance 1.25
Pain Relevance 4.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cnr1) aging (Cnr1) plasma membrane (Cnr1)
signal transducer activity (Cnr1)
Anatomy Link Frequency
neurons 4
pyramidal cells 2
neuromuscular junction 2
Cnr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Cannabinoid 263 100.00 Very High Very High Very High
Cannabinoid receptor 23 100.00 Very High Very High Very High
dopamine receptor 14 100.00 Very High Very High Very High
Glutamate 111 99.56 Very High Very High Very High
analgesia 28 99.36 Very High Very High Very High
Morphine 47 98.56 Very High Very High Very High
gABA 61 97.44 Very High Very High Very High
antagonist 79 97.16 Very High Very High Very High
tolerance 50 96.72 Very High Very High Very High
agonist 188 96.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Status Epilepticus 148 99.88 Very High Very High Very High
Targeted Disruption 4 99.18 Very High Very High Very High
Epilepsy 206 77.28 Quite High
Convulsion 137 75.64 Quite High
Dizziness 6 63.52 Quite High
Vomiting 18 62.40 Quite High
Disease 23 50.64 Quite High
Body Weight 4 49.32 Quite Low
Sprains And Strains 5 45.28 Quite Low
Sleep Disorders 4 43.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found no significant effects of CB1R activation on overall sEPSCs or mEPSCs in control mice, but effects of CB1R activation specifically on mossy cell inputs were not tested.
Neg (no) Regulation (effects) of Positive_regulation (activation) of CB1R
1) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871782 Disease Relevance 0.29 Pain Relevance 0.41
Effect of CB1R activation on mEPSCs
Regulation (Effect) of Positive_regulation (activation) of CB1R
2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871782 Disease Relevance 0.23 Pain Relevance 0.27
Effect of CB1R activation on population responses
Regulation (Effect) of Positive_regulation (activation) of CB1R
3) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871782 Disease Relevance 0.20 Pain Relevance 0.25
To investigate the effect of presynaptic CB1 receptor activation on hippocampal inhibition, we recorded inhibitory postsynaptic currents (IPSCs) from principal cells.
Spec (investigate) Regulation (effect) of Spec (investigate) Positive_regulation (activation) of CB1 receptor associated with cannabinoid receptor
4) Confidence 0.45 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 10998107 Disease Relevance 0 Pain Relevance 0.76
Together these data show an inhibitory effect of CB1 activation on evoked acetylcholine release and the first evidence for the presence of a vanilloid receptor at the neuromuscular junction.
Regulation (effect) of Positive_regulation (activation) of CB1 in neuromuscular junction
5) Confidence 0.29 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20176082 Disease Relevance 0 Pain Relevance 0.41
Effect of CB1R activation on sEPSCs
Regulation (Effect) of Positive_regulation (activation) of CB1R
6) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871782 Disease Relevance 0.26 Pain Relevance 0.29
The influence of the activation of CB1Rs on supraspinal analgesia evoked by morphine was also evaluated.


Regulation (influence) of Positive_regulation (activation) of CB1Rs associated with morphine and analgesia
7) Confidence 0.27 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2657119 Disease Relevance 0 Pain Relevance 1.50
It has recently been established that cannabinoids play an important role in the activity of neurons of the vestibular nuclei through the activation of cannabinoid CB1 type receptors [132].
Regulation (role) of Positive_regulation (activation) of CB1 in neurons associated with cannabinoid
8) Confidence 0.26 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866460 Disease Relevance 0.18 Pain Relevance 0.64
Whole cell voltage clamp recordings were performed to measure the effects of CB1R activation on excitatory synaptic responses evoked in the presence of the GABA-A antagonist picrotoxin (100 ┬ÁM) by stimulating layer 2/3 to layer 5/6 pyramidal cells synapses.
Regulation (effects) of Positive_regulation (activation) of CB1R in pyramidal cells associated with gaba, pyramidal cell and antagonist
9) Confidence 0.26 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1933592 Disease Relevance 0 Pain Relevance 0.34
Therefore, to obtain a further specific deletion of CB1 in striatal neurons, we crossed CB1f/f mice with a transgenic mouse line where Cre recombinase is expressed under the control of the regulatory sequences of dopamine receptor D1 (D1-Cre) [36,37] to generate D1-CB1?
Regulation (under) of Positive_regulation (generate) of D1-CB1 in neurons associated with targeted disruption and dopamine receptor
10) Confidence 0.24 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2001214 Disease Relevance 0.10 Pain Relevance 0.13

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