INT9097

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Context Info
Confidence 0.41
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.33
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (DNASE1L3) DNA binding (DNASE1L3) DNA metabolic process (DNASE1L3)
DNASE1L3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cannabis 83 99.80 Very High Very High Very High
alcohol 7 97.52 Very High Very High Very High
fluoxetine 1 97.04 Very High Very High Very High
Paracetamol 1 83.84 Quite High
cocaine 6 5.00 Very Low Very Low Very Low
opiate 3 5.00 Very Low Very Low Very Low
drug abuse 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Overdose 3 95.04 Very High Very High Very High
Mental Disorders 17 88.24 High High
Schizophrenia 36 62.08 Quite High
Psychosis 14 29.16 Quite Low
Anxiety Disorder 12 5.00 Very Low Very Low Very Low
Drug Dependence 4 5.00 Very Low Very Low Very Low
Nicotine Addiction 4 5.00 Very Low Very Low Very Low
Paranoid Disorders 4 5.00 Very Low Very Low Very Low
Poisoning 3 5.00 Very Low Very Low Very Low
Sleep Disorders 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two cases are presented that suggest decreased sensitivity to the serotonergic hallucinogens psilocybin and LSD induced by drugs with effects on serotonergic neurotransmission, allopurinol and fluoxetine.
Positive_regulation (induced) of LSD associated with fluoxetine
1) Confidence 0.41 Published 1992 Journal Neuropsychopharmacology Section Abstract Doc Link 1388647 Disease Relevance 0 Pain Relevance 0.10
A white male participant, in his late 30 s who had injected amphetamines and used LSD and cannabis heavily, gave up drugs for a partner and became alcohol dependent; he said:

"They didn't realise I was taking overdoses and things like that.

Positive_regulation (used) of LSD associated with cannabis, overdose and alcohol
2) Confidence 0.03 Published 2010 Journal BMC Psychiatry Section Body Doc Link PMC2999587 Disease Relevance 0.33 Pain Relevance 0.28

General Comments

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