INT90981

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Context Info
Confidence 0.42
First Reported 2000
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 5
Disease Relevance 1.44
Pain Relevance 2.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Dio1) endoplasmic reticulum (Dio1)
Anatomy Link Frequency
nucleus accumbens 2
striatum 2
Dio1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 38 100.00 Very High Very High Very High
substance P 2 99.08 Very High Very High Very High
Nucleus accumbens 12 98.92 Very High Very High Very High
Dynorphin 2 96.64 Very High Very High Very High
Substantia nigra 12 91.00 High High
Tetrahydrobiopterin 4 78.56 Quite High
Neuropeptide 10 78.12 Quite High
dopamine receptor 6 77.44 Quite High
Enkephalin 5 25.00 Low Low
Disease Link Frequency Relevance Heat
Dystonia 20 96.56 Very High Very High Very High
Targeted Disruption 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By in situ hybridization, we detected striatal dopamine D1, D2, D3 receptor, and substance P mRNAs at G13, preproenkephalin A mRNA at G14 and dynorphin mRNA at G17 in normal mice.
Transcription (detected) of D1 associated with dopamine, dynorphin and substance p
1) Confidence 0.42 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 10998124 Disease Relevance 0.07 Pain Relevance 0.57
In the striatum and nucleus accumbens, expression of PPT mRNA was elevated but PPE-A mRNA, D-1, D-2 receptor, and nNOS mRNA were not changed in hph-1 mice compared to controls.
Transcription (changed) of D-1 in nucleus accumbens associated with nucleus accumbens
2) Confidence 0.10 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15530890 Disease Relevance 0.32 Pain Relevance 0.55
In the present study, the density of striatal DA terminals and DA receptors and the expression of D-1, D-2, and D-3 receptors, preproenkephalin (PPE-A), preprotachykinin (PPT), and nitric oxide synthase (NOS) mRNAs in the striatum and nucleus accumbens and nigral TH mRNA expression were examined.
Transcription (expression) of D-1 in nucleus accumbens associated with nucleus accumbens and dopamine
3) Confidence 0.08 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15530890 Disease Relevance 0.36 Pain Relevance 0.59
In the striatum and nucleus accumbens, expression of PPT mRNA was elevated but PPE-A mRNA, D-1, D-2 receptor, and nNOS mRNA were not changed in hph-1 mice compared to controls.
Transcription (changed) of D-1 in striatum associated with nucleus accumbens
4) Confidence 0.04 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15530890 Disease Relevance 0.32 Pain Relevance 0.55
In the present study, the density of striatal DA terminals and DA receptors and the expression of D-1, D-2, and D-3 receptors, preproenkephalin (PPE-A), preprotachykinin (PPT), and nitric oxide synthase (NOS) mRNAs in the striatum and nucleus accumbens and nigral TH mRNA expression were examined.
Transcription (expression) of D-1 in striatum associated with nucleus accumbens and dopamine
5) Confidence 0.03 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15530890 Disease Relevance 0.36 Pain Relevance 0.59

General Comments

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