INT90987

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Context Info
Confidence 0.00
First Reported 2000
Last Reported 2000
Negated 1
Speculated 1
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.66

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plasma membrane (Oprl1, Oprl1) signal transducer activity (Oprl1, Oprl1) signal transduction (Oprl1)
Oprl1 (Mus musculus)
Oprl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
orphanin 7 100.00 Very High Very High Very High
Opioid 2 98.60 Very High Very High Very High
Dynorphin 3 96.42 Very High Very High Very High
Kappa opioid receptor 1 96.16 Very High Very High Very High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of the kappa-opioid receptor by dynorphin A is thought to require interactions of its N-terminal hydrophobic domain (Y(1)GGF) with the receptor opioid binding pocket, located within the transmembrane helix bundle, while activation of the ORL1 receptor appears to require interactions of the positively charged core (R(8)KSARK) of nociceptin with the negatively charged second extracellular receptor loop.
Positive_regulation (activation) of ORL1 receptor Spec (appears) Positive_regulation (require) of nociceptin Neg (negatively) Binding (interactions) of associated with dynorphin, orphanin, kappa opioid receptor and opioid
1) Confidence 0.00 Published 2000 Journal Peptides Section Abstract Doc Link 10998522 Disease Relevance 0 Pain Relevance 0.66

General Comments

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