INT91

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Context Info
Confidence 0.70
First Reported 1976
Last Reported 2010
Negated 4
Speculated 6
Reported most in Abstract
Documents 96
Total Number 108
Disease Relevance 23.22
Pain Relevance 29.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gast) extracellular region (Gast)
Anatomy Link Frequency
neurons 12
stomach 11
plasma 6
neural 6
D cells 6
Gast (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 315 100.00 Very High Very High Very High
agonist 67 100.00 Very High Very High Very High
opiate 10 100.00 Very High Very High Very High
vagus nerve 4 100.00 Very High Very High Very High
anesthesia 10 99.84 Very High Very High Very High
Bile 4 99.84 Very High Very High Very High
gABA 51 99.82 Very High Very High Very High
Cholecystokinin 23 99.80 Very High Very High Very High
peptic ulcer disease 32 99.76 Very High Very High Very High
Endogenous opioid 12 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 48 100.00 Very High Very High Very High
Infection 32 99.98 Very High Very High Very High
Gastritis 27 99.98 Very High Very High Very High
Ulcers 96 99.76 Very High Very High Very High
Duodenal Ulcer 48 99.74 Very High Very High Very High
Peptic Ulcer 12 99.38 Very High Very High Very High
Syndrome 10 99.20 Very High Very High Very High
Nicotine Addiction 12 99.12 Very High Very High Very High
Pancreatitis 9 99.08 Very High Very High Very High
Ganglion Cysts 28 98.46 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rat antral mucosal fragments were maintained in short-term culture to examine the relative potencies and receptor specificity of the cholinergic agonist, carbachol, and adrenergic agents, norepinephrine, isoproterenol, clonidine and phenylephrine in stimulating gastrin release.
Positive_regulation (stimulating) of Localization (release) of gastrin associated with agonist and clonidine
1) Confidence 0.70 Published 1988 Journal Peptides Section Abstract Doc Link 3420006 Disease Relevance 0 Pain Relevance 0.20
A contribution of cholinergic mechanisms to this vagovagal-mediated stimulation of distention-induced gastrin release was excluded, since atropine (100 microg/kg/h; n = 8) further augmented distention-stimulated gastrin release.
Positive_regulation (augmented) of Localization (release) of gastrin
2) Confidence 0.70 Published 1997 Journal Regul. Pept. Section Abstract Doc Link 9163580 Disease Relevance 0 Pain Relevance 0.25
In the rat the exact role of vagal fibers and the interaction between the extrinsic and intrinsic neural system in distention-induced gastrin release are still a matter of debate.
Positive_regulation (induced) of Localization (release) of gastrin in neural
3) Confidence 0.70 Published 1997 Journal Regul. Pept. Section Abstract Doc Link 9163580 Disease Relevance 0 Pain Relevance 0
Since bombesin/gastrin-releasing peptide (GRP)-neurons contribute to vagally stimulated gastrin secretion, we have examined gastrin response to distention in the presence of the specific bombesin-receptor antagonist D-Phe6-BN(6-13)OMe (400 microg/kg/h: n = 10).
Positive_regulation (contribute) of Localization (secretion) of gastrin in neurons associated with antagonist
4) Confidence 0.70 Published 1997 Journal Regul. Pept. Section Abstract Doc Link 9163580 Disease Relevance 0 Pain Relevance 0.26
Stimulation of gastrin release by 10 ml distention in sham-operated control rats was reversed to an inhibition after truncal vagotomy (26+/-7 vs. -11+/-4 pg/ml; P<0.05) and capsaicin-treatment (37+/-18 vs. -34+/-11 pg/ml; P<0.05).
Positive_regulation (Stimulation) of Localization (release) of gastrin associated with qutenza
5) Confidence 0.70 Published 1997 Journal Regul. Pept. Section Abstract Doc Link 9163580 Disease Relevance 0 Pain Relevance 0.19
These data demonstrate, that in anesthetized rats distention-stimulated gastrin secretion depends on the activation of a vagovagal reflex and intrinsic bombesin/GRP-neurons.
Positive_regulation (stimulated) of Localization (secretion) of gastrin in neurons
6) Confidence 0.70 Published 1997 Journal Regul. Pept. Section Abstract Doc Link 9163580 Disease Relevance 0 Pain Relevance 0.22
A contribution of cholinergic mechanisms to this vagovagal-mediated stimulation of distention-induced gastrin release was excluded, since atropine (100 microg/kg/h; n = 8) further augmented distention-stimulated gastrin release.
Positive_regulation (stimulated) of Localization (release) of gastrin
7) Confidence 0.70 Published 1997 Journal Regul. Pept. Section Abstract Doc Link 9163580 Disease Relevance 0 Pain Relevance 0.25
A contribution of cholinergic mechanisms to this vagovagal-mediated stimulation of distention-induced gastrin release was excluded, since atropine (100 microg/kg/h; n = 8) further augmented distention-stimulated gastrin release.
Positive_regulation (induced) of Localization (release) of gastrin
8) Confidence 0.70 Published 1997 Journal Regul. Pept. Section Abstract Doc Link 9163580 Disease Relevance 0 Pain Relevance 0.25
Perfusion with 0.5% or 5% peptone solutions stimulated gastrin secretion and inhibited somatostatin secretion.
Positive_regulation (stimulated) of Localization (secretion) of gastrin associated with somatostatin
9) Confidence 0.69 Published 1984 Journal Gastroenterology Section Abstract Doc Link 6146551 Disease Relevance 0 Pain Relevance 0.25
Intraluminal perfusion with alkaline solutions (0.1 M NaHCO3) increased gastrin secretion, whereas perfusion with acid solutions (pH 3.5-3.0) inhibited gastrin secretion.
Positive_regulation (increased) of Localization (secretion) of gastrin
10) Confidence 0.69 Published 1984 Journal Gastroenterology Section Abstract Doc Link 6146551 Disease Relevance 0 Pain Relevance 0.20
Stimulation of gastrin secretion in vitro by intraluminal chemicals: regulation by intramural cholinergic and noncholinergic neurons.
Positive_regulation (Stimulation) of Localization (secretion) of gastrin in neurons
11) Confidence 0.69 Published 1984 Journal Gastroenterology Section Title Doc Link 6146551 Disease Relevance 0 Pain Relevance 0.22
Methacholine, a muscarinic receptor agonist, only weakly stimulated gastrin release from vagotomized stomachs when compared with shamoperated controls, indicating that a cholinergic drive was already in place.
Positive_regulation (stimulated) of Localization (release) of gastrin in stomachs associated with agonist
12) Confidence 0.69 Published 1984 Journal Am. J. Physiol. Section Abstract Doc Link 6148016 Disease Relevance 0 Pain Relevance 0.15
Field stimulation caused an increase in gastrin and somatostatin secretion that was dependent on the strength of the stimulus (10-30 V).
Positive_regulation (caused) of Localization (secretion) of gastrin associated with somatostatin
13) Confidence 0.69 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 2892415 Disease Relevance 0 Pain Relevance 0.35
DMPP caused lesser, though significant, increases in gastrin (166%) and somatostatin (83%) secretion that were nearly abolished by hexamethonium (84-91%) but were not significantly affected by atropine.
Positive_regulation (increases) of Localization (secretion) of gastrin associated with somatostatin
14) Confidence 0.69 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 2892415 Disease Relevance 0 Pain Relevance 0.47
These studies have suggested that hypersecretion of gastric acid may not be associated with duodenal ulcer or gastric ulcer disease in children, and that increased gastrin secretion and possible reduced acid responsiveness coexist in children with duodenal ulcers.
Spec (possible) Positive_regulation (increased) of Localization (secretion) of gastrin associated with duodenal ulcer, disease and peptic ulcer
15) Confidence 0.68 Published 1980 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 7451920 Disease Relevance 1.84 Pain Relevance 0.57
After the intraduodenal test meal in 4 normal subjects and in 17 DU patients an increase of gastric acid secretion and serum gastrin was measured.
Positive_regulation (increase) of Localization (secretion) of gastrin associated with duodenal ulcer
16) Confidence 0.68 Published 1976 Journal Gastroenterology Section Abstract Doc Link 8356 Disease Relevance 0.68 Pain Relevance 0
Increased gastrin release in chronic calcifying pancreatitis and in chronic alcoholism.
Positive_regulation (Increased) of Localization (release) of gastrin associated with alcohol addiction and pancreatitis
17) Confidence 0.68 Published 1980 Journal Horm. Metab. Res. Section Title Doc Link 7409735 Disease Relevance 0.45 Pain Relevance 0.12
From these data it is concluded: (1) Intraduodenal application of a test meal results in release of gastrin from extragastric sites. (2) Extragastric gastrin is biologically active. (3) DU patients are able to release more antral and more extragastric gastrin in response to a test meal.
Positive_regulation (results) of Localization (release) of gastrin associated with duodenal ulcer
18) Confidence 0.68 Published 1976 Journal Gastroenterology Section Abstract Doc Link 8356 Disease Relevance 0.64 Pain Relevance 0.08
Whole bacterial sonic extracts and water-extracted surface proteins, but not PBS extracts, from strains 43579 (CagA+/VacA+), 60190 (CagA+/VacA+), and 60190:v1 (CagA+/VacA-) significantly stimulated gastrin release.
Neg (not) Positive_regulation (stimulated) of Localization (release) of gastrin associated with sprains and strains
19) Confidence 0.68 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9696722 Disease Relevance 0.27 Pain Relevance 0.11
H. pylori stimulates gastrin release from canine antral cells in primary culture.
Positive_regulation (stimulates) of Localization (release) of gastrin
20) Confidence 0.68 Published 1998 Journal Am. J. Physiol. Section Title Doc Link 9696722 Disease Relevance 0.25 Pain Relevance 0.10

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