INT9100

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Context Info
Confidence 0.48
First Reported 1992
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 4.89
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (CAMKK2) cytoplasm (CAMKK2)
Anatomy Link Frequency
neurons 1
CAMKK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 11 99.32 Very High Very High Very High
ischemia 10 98.92 Very High Very High Very High
Glutamate 3 95.72 Very High Very High Very High
Intracerebroventricular 2 94.00 High High
Kinase C 1 94.00 High High
adenocard 2 88.64 High High
antagonist 24 86.08 High High
agonist 52 82.00 Quite High
tolerance 2 69.80 Quite High
local anesthetic 1 59.68 Quite High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 6 98.92 Very High Very High Very High
Hypothermia 8 97.92 Very High Very High Very High
Weight Gain 10 97.72 Very High Very High Very High
Hyperglycemia 2 97.20 Very High Very High Very High
Infection 50 96.52 Very High Very High Very High
Insulin Resistance 10 96.44 Very High Very High Very High
Hepatitis B Virus Infection 43 90.96 High High
Hepatitis D Virus Infection 55 90.64 High High
Obesity 198 84.72 Quite High
Injury 2 79.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, the inhibition of calcium-calmodulin-dependent protein kinase II triggered by normothermic ischemia is prevented by hypothermia, as is the ischemia-induced translocation and inhibition of the key regulatory enzyme protein kinase C.
Negative_regulation (inhibition) of calcium-calmodulin-dependent protein kinase II associated with hypothermia, kinase c and ischemia
1) Confidence 0.48 Published 1992 Journal Cerebrovasc Brain Metab Rev Section Abstract Doc Link 1389956 Disease Relevance 1.47 Pain Relevance 0.50
The absence of CaMKK2 was also demonstrated to protect mice from diet-induced weight gain, hyperglycemia, and insulin resistance.
Negative_regulation (absence) of CaMKK2 associated with hyperglycemia, insulin resistance and weight gain
2) Confidence 0.27 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC3010692 Disease Relevance 0.63 Pain Relevance 0.23
The resistance of CaMKK2 null mice to suppression of food intake by STO-609 infusion provides compelling evidence that CaMKK2 is the direct target of the drug and that the specific inhibition of CaMKK2 in NPY neurons is likely responsible for the reduced level of NPY and AgRP mRNAs and feeding behavior [100].
Negative_regulation (inhibition) of CaMKK2 in neurons
3) Confidence 0.27 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC3010692 Disease Relevance 0.95 Pain Relevance 0.16
Also tested was KN62, a molecule first developed as a specific cell-permeable inhibitor of the autophosphorylation of Ca++/calmodulin-dependent protein kinase II.
Negative_regulation (inhibitor) of kinase II
4) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004961 Disease Relevance 1.84 Pain Relevance 0.04

General Comments

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