INT91013

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Context Info
Confidence 0.46
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 8.70
Pain Relevance 2.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (IFNAR1)
Anatomy Link Frequency
neuronal 1
muscle 1
upper arm 1
IFNAR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 151 100.00 Very High Very High Very High
Hyperalgesia 28 100.00 Very High Very High Very High
reflex sympathetic dystrophy 9 99.82 Very High Very High Very High
epidural 15 97.36 Very High Very High Very High
Pain refractory 2 95.80 Very High Very High Very High
spinal-cord stimulation 26 88.64 High High
tricyclic antidepressant 8 80.72 Quite High
allodynia 12 80.04 Quite High
Rsd 3 75.00 Quite High
Cold hyperalgesia 10 74.20 Quite High
Disease Link Frequency Relevance Heat
Complex Regional Pain Syndromes 331 100.00 Very High Very High Very High
Reflex Sympathetic Dystrophy 134 100.00 Very High Very High Very High
Hyperalgesia 40 100.00 Very High Very High Very High
Movement Disorders 4 99.98 Very High Very High Very High
Dystonia 18 99.60 Very High Very High Very High
Sleep Disorders 3 99.16 Very High Very High Very High
Congenital Anomalies 8 99.12 Very High Very High Very High
Muscular Spasm 8 99.08 Very High Very High Very High
Chronic Disease 2 99.06 Very High Very High Very High
Pain 176 99.02 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Zolpidem binds selectively to the benzodiazepine omega-1 receptor and increases the frequency of chloride channel opening, which results in inhibition of neuronal excitation.
benzodiazepine omega-1 receptor Binding (binds) of in neuronal
1) Confidence 0.46 Published 2002 Journal J. Vet. Intern. Med. Section Abstract Doc Link 11899040 Disease Relevance 0.36 Pain Relevance 0
Complex regional pain syndrome type I (CRPS-I) is infrequently associated with various malignancies, and may lead to severe pain in already debilitated patients.
CRPS-I Binding (associated) of associated with complex regional pain syndromes, pain and reflex sympathetic dystrophy
2) Confidence 0.24 Published 2000 Journal Curr Rev Pain Section Abstract Doc Link 10998738 Disease Relevance 0.63 Pain Relevance 0.27
This development must be accompanied by research into possible underlying pathophysiological mechanisms (such as genetic factors) associated with CRPS-I, with particular attention being paid to possible sub-groups of the condition related to these underlying mechanisms.
CRPS-I Binding (associated) of associated with complex regional pain syndromes
3) Confidence 0.20 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2861029 Disease Relevance 0.50 Pain Relevance 0.31
There is insufficient evidence of the efficacy of muscle relaxants in treating movement disorders associated with CRPS-I, such as dystonia and muscle spasms (level 3: Bathia et al.
CRPS-I Binding (associated) of in muscle associated with complex regional pain syndromes, movement disorders, muscular spasm and dystonia
4) Confidence 0.20 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2861029 Disease Relevance 1.98 Pain Relevance 0.07
The patients in our study, most of whom had chronic illnesses, needed and were able to co-construct healing interactions, interactions that we argue are I-Thou relationships, with their clinicians within the usual constraints of modern medical care, including 15 minute visits.
I-Thou Binding (interactions) of associated with chronic disease
5) Confidence 0.19 Published 2009 Journal Philos Ethics Humanit Med Section Body Doc Link PMC2733137 Disease Relevance 0.16 Pain Relevance 0
The patients in our study, most of whom had chronic illnesses, needed and were able to co-construct healing interactions, interactions that we argue are I-Thou relationships, with their clinicians within the usual constraints of modern medical care, including 15 minute visits.
I-Thou Binding (interactions) of associated with chronic disease
6) Confidence 0.19 Published 2009 Journal Philos Ethics Humanit Med Section Body Doc Link PMC2733137 Disease Relevance 0.16 Pain Relevance 0
These results support the hypothesis that CRPS-I is specifically associated with post-traumatic focal MDNI affecting nociceptive small-fibers.
CRPS-I Binding (associated) of associated with nociception, complex regional pain syndromes and nervous system injury
7) Confidence 0.08 Published 2006 Journal Pain Section Abstract Doc Link 16427737 Disease Relevance 1.65 Pain Relevance 0.69
Thus, the pain in her right upper arm was considered as spread phenomenon of CRPS-I.
CRPS-I Binding (phenomenon) of in upper arm associated with complex regional pain syndromes and pain
8) Confidence 0.04 Published 2009 Journal Masui Section Abstract Doc Link 19764441 Disease Relevance 0.89 Pain Relevance 0.74
Interaction of Hyperalgesia and Sensory Loss in Complex Regional Pain Syndrome Type I (CRPS I)

Background

CRPS I Binding (Interaction) of associated with pain, hyperalgesia and reflex sympathetic dystrophy
9) Confidence 0.02 Published 2008 Journal PLoS ONE Section Title Doc Link PMC2453233 Disease Relevance 1.42 Pain Relevance 0.60
Due to a persistently negative HCV-PCR from serum (from week 12 onwards), consensus interferon treatment was not stopped but continued until week 60 according to the study protocol. - Cutaneous mucinosis has not been previously reported to complicate treatment with consensus interferon in patients with chronic hepatitis C and should therefore be added to the list of dermatological side-effects associated with interferon alfacon-1 therapy.
interferon alfacon-1 Binding (associated) of associated with mucinoses, chronic hepatitis and hepatitis c virus infection
10) Confidence 0.01 Published 2005 Journal Eur. J. Med. Res. Section Abstract Doc Link 15817424 Disease Relevance 0.95 Pain Relevance 0.06

General Comments

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