INT91035

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Context Info
Confidence 0.66
First Reported 2000
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 5.20
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (HSD17B2)
Anatomy Link Frequency
endometrium 5
stromal cells 1
HSD17B2 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 15 85.92 High High
Dismenorea 6 70.28 Quite High
pain pelvic 2 56.92 Quite High
Inflammation 2 53.80 Quite High
Pain 1 52.36 Quite High
Disease Link Frequency Relevance Heat
Endometriosis 13 98.60 Very High Very High Very High
Disease 54 97.44 Very High Very High Very High
Cervical Cancer 6 79.20 Quite High
Gynecological Disease 6 75.92 Quite High
Uterine Fibroids 6 71.04 Quite High
Dysmenorrhea 6 70.28 Quite High
Endometriosis (extended) 6 69.76 Quite High
Reprotox - General 3 2 56.92 Quite High
INFLAMMATION 2 53.80 Quite High
Pain 1 52.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that the previous paradigm that 17betaHSD2 activity in the endometrium is elevated during the secretory phase is confined to diseased endometrium but not to disease-free endometrium and that the estrogen metabolism is altered in the endometria of the patients with estrogen-dependent benign diseases.
Positive_regulation (elevated) of 17betaHSD2 in endometrium associated with disease
1) Confidence 0.66 Published 2000 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 10999824 Disease Relevance 0.91 Pain Relevance 0.08
Progesterone induction of 17beta-hydroxysteroid dehydrogenase type 2 during the secretory phase occurs in the endometrium of estrogen-dependent benign diseases but not in normal endometrium.
Positive_regulation (induction) of 17beta-hydroxysteroid dehydrogenase type 2 in endometrium associated with disease
2) Confidence 0.66 Published 2000 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 10999824 Disease Relevance 0.61 Pain Relevance 0.10
Previous studies have shown that the 17betaHSD2 activity in the endometrium is elevated during the secretory phase, as compared with the level during the proliferative phase, and that the elevation is in response to progesterone via the progesterone receptors.
Positive_regulation (elevated) of 17betaHSD2 in endometrium
3) Confidence 0.66 Published 2000 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 10999824 Disease Relevance 0.45 Pain Relevance 0.09
Previous studies have shown that the 17betaHSD2 activity in the endometrium is elevated during the secretory phase, as compared with the level during the proliferative phase, and that the elevation is in response to progesterone via the progesterone receptors.
Positive_regulation (elevation) of 17betaHSD2 in endometrium
4) Confidence 0.45 Published 2000 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 10999824 Disease Relevance 0.55 Pain Relevance 0.10
Organ culture of proliferative endometria in the presence of progestins resulted in the stimulation of 17betaHSD2 in diseased endometria via the progesterone receptors, whereas disease-free endometrium was not stimulated by progestins.
Positive_regulation (stimulation) of 17betaHSD2 in endometrium associated with disease
5) Confidence 0.39 Published 2000 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 10999824 Disease Relevance 0.85 Pain Relevance 0.10
Kinetic studies showed that the Km was identical among the four groups of endometria, suggesting that the elevation of 17betaHSD2 simply resulted from increased mRNA transcription.
Positive_regulation (elevation) of 17betaHSD2
6) Confidence 0.39 Published 2000 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 10999824 Disease Relevance 0.90 Pain Relevance 0.11
The inability of endometriotic stromal cells to produce progesterone-induced paracrine factors that stimulate 17beta-HSD-2 may be due to the lack of PR-B and very low levels of progesterone receptor A (PR-A) observed in vivo in endometriotic tissue.
Positive_regulation (stimulate) of 17beta-HSD-2 in stromal cells associated with endometriosis
7) Confidence 0.01 Published 2006 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 16406281 Disease Relevance 0.93 Pain Relevance 0.41

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